Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 18, 2025

Mammalian milk contains a variety of complex bioactive and nutritional components microorganisms. These microorganisms have diverse compositions functional roles that impact host health disease pathophysiology, especially mastitis. The advent use high throughput omics technologies, including metagenomics, metatranscriptomics, metaproteomics, metametabolomics, as well culturomics in microbiome studies suggest strong relationships between phenotype signatures While single undoubtedly contributed to our current understanding mastitis, they often provide limited information, targeting only biological viewpoint which is insufficient system-wide information necessary for elucidating the footprints molecular mechanisms driving mastitis dysbiosis. Therefore, integrating multi-omics approach research could generate new knowledge, improve structural ecosystem, insights sustainable control management.

Language: Английский

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Nutrition for Optimal Lactation

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 21, 2025

Background:: Breastfeeding is the ideal method of feeding for all newborns and associated with multiple positive health outcomes. Human milk provides essential nutrients bioactive molecules needed optimal infant development. Maternal nutrition during lactation plays an important role in supporting breastfeeding preventing metabolic imbalances. The aim this narrative review was to describe most prevalent issues lactating women provide a summary current diet recommendations as well controversies on supplementation, order facilitate information clinicians professionals. Summary:: nutritionally demanding stage adequate key avoid alterations maternal nutritional status, produce quantity good quality, programming diseases. Anemia vitamin D, A, iodine, iron deficiencies are common, while obesity diseases keep rising. Inadequate intake many also frequent stage.

Language: Английский

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Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3087 - 3087

Published: July 10, 2023

Breastmilk is the optimal source of infant nutrition, with short-term and long-term health benefits. Some these benefits are mediated by human milk oligosaccharides (HMOs), a unique group carbohydrates representing third most abundant solid component milk. We performed first clinical study on formula supplemented five different HMOs (5HMO-mix), comprising 2'-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, 3'-sialyllactose 6'-sialyllactose at natural total concentration 5.75 g/L, here report analysis fecal microbiome. found an increase in relative abundance bifidobacteria 5HMO-mix cohort compared formula-fed control, specifically affecting that can produce aromatic lactic acids. influenced microbial composition as early Week 1, observed changes persisted to least 16, including decrease species opportunistic pathogenic strains down level breastfed infants during 4 weeks. further analyzed functional potential microbiome features shared between 5HMO-mix-supplemented infants, such enrichment mucus tyrosine degradation, latter possibly being linked The supplement, therefore, shifts closer infants.

Language: Английский

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Human milk oligosaccharide composition is affected by season and parity and associates with infant gut microbiota in a birth mode dependent manner in a Finnish birth cohort

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105182 - 105182

Published: June 1, 2024

Human milk oligosaccharides (HMOs), their determinants, infant gut microbiota and health are under extensive research; however, seldom jointly addressed. Leveraging data from the HELMi birth cohort, we investigated them collectively, considering maternal secretor status.

Language: Английский

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The role of antibiotic exposure and the effects of breastmilk and human milk feeding on the developing infant gut microbiome

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: June 6, 2024

The World Health Organization (WHO) recommends exclusive breastfeeding for the first 6 months of life followed by complementary foods and sustained at least 2 years, underscoring its pivotal role in reducing infant mortality preventing various illnesses. This perspective delves into intricate relationship between practices, early antibiotic exposure, gut microbiome development, highlighting their profound influence on child health outcomes. Antibiotics are extensively prescribed during pregnancy childhood, disrupting microbiome, related to increased risks allergies, obesity, neurodevelopmental disorders. Breastfeeding is a significant determinant healthier characterized higher levels beneficial bacteria such as Bifidobacterium lower potential pathogens. Despite widespread recognition benefits breastfeeding, gaps persist healthcare practices support mechanisms, exacerbating challenges faced families. highlights pressing need comprehensive research encompassing behaviors, human milk intake, impact Additionally, promoting awareness among providers families regarding detrimental effects unnecessary formula supplementation could facilitate informed decision-making bolster rates. Moreover, donor (DHM) promising alternative formula, potentially mitigating disruptions after exposure. Overall, prioritizing interventions bridging essential steps towards improving outcomes global scale.

Language: Английский

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Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases

Food Research International, Journal Year: 2024, Volume and Issue: 182, P. 114143 - 114143

Published: Feb. 28, 2024

Language: Английский

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Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147

Published: March 1, 2024

Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.

Language: Английский

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Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis

Gut, Journal Year: 2024, Volume and Issue: 74(1), P. 45 - 57

Published: July 30, 2024

The specific breast milk-derived metabolites that mediate host-microbiota interactions and contribute to the onset of atopic dermatitis (AD) remain unknown require further investigation.

Language: Английский

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Product management challenges and innovations in baby food: The Nigerian and US Market

GSC Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 19(1), P. 004 - 015

Published: April 7, 2024

This review examines the landscape of baby food product management, highlighting diverse nutritional needs, innovative practices, and regulatory challenges encountered by companies operating in Nigeria United States (US). As essential stakeholders infant health, manufacturers must navigate a complex terrain shaped cultural preferences, economic factors, governmental regulations to meet requirements infants young children. In both US, needs are paramount, with an increasing emphasis on providing balanced diets that support optimal growth development. However, specific dietary may vary between regions due regional agricultural availability, socio-economic factors. Understanding catering these nuanced is critical for establish trust credibility among consumers. Moreover, innovations management play crucial role addressing evolving consumer demands preferences. From organic natural ingredients convenient packaging solutions, continuously striving enhance quality convenience products. These not only reflect shifting trends but also serve as competitive differentiator crowded market. Nevertheless, navigating presents significant US. Regulatory frameworks governing safety, labeling requirements, advertising standards subject frequent updates modifications, requiring maintain agility compliance. Additionally, perceptions surrounding feeding practices influence approaches, further complicating market entry expansion strategies. underscores importance understanding unique embracing products By adopting comprehensive approach considers market-specific factors global best can effectively markets contribute health well-being

Language: Английский

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Galacto-oligosaccharides (GOS) and the Elderly Gut: Implications for Immune Restoration and Health.

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(8), P. 100263 - 100263

Published: June 17, 2024

The increasing prevalence of noncommunicable diseases in the aging population has been correlated with a decline innate and adaptive immune responses; hence, it is imperative to identify approaches improve function, prevent related disorders, reduce or treat age-associated health complications. Prebiotic supplementation promising approach modulate gut microbiome system, offering potential strategy maintain integrity function older individuals. This review summarizes current research on prebiotic galacto-oligosaccharide (GOS) immunomodulatory mechanisms mediated by bacterial-derived metabolites, including short-chain fatty acids secondary bile acids, homeostasis. applications GOS as immunotherapy for age-related disease prevention individuals are also highlighted. aligns global shift toward proactive healthcare emphasizes significance early intervention directing an individual's trajectory.

Language: Английский

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