Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(7), P. 1397 - 1414

Published: June 27, 2024

Language: Английский

---

Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota

Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

---

Gut–X axis

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

---

Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 10, 2023

Type 2 diabetes (T2DM) clinically exhibits a higher incidence of hepatocellular carcinoma (HCC), contributing to lousy prognosis in patients harboring both diseases. Microflora-based therapy draws attention with low side effects. Accumulating evidence shows that Lactobacillus brevis can improve blood glucose and body weight the T2DM mice model reduce several cancer incidences. However, therapeutic effect affecting T2DM+HCC remains unknown. In this study, we aim explore question via an established model. We observed significant alleviation after probiotic intervention. improves insulin resistance ameliorates Mechanically. Combined multi-omics approach including 16SrDNA, GC-MS, RNA-seq, identified distinct intestinal microflora composition metabolites Furthermore, found delayed disease progression by regulating MMP9 NOTCH 1 signaling pathways, potentially through gut BA interaction. This study indicates may + HCC, providing novel opportunities targeting flora for T2DM+HCC.

Language: Английский

---

Research progress on the relationship between bile acid metabolism and type 2 diabetes mellitus

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: Nov. 17, 2023

Abstract Bile acids, which are steroid molecules originating from cholesterol and synthesized in the liver, play a pivotal role regulating glucose metabolism maintaining energy balance. Upon release into intestine alongside bile, they activate various nuclear membrane receptors, influencing crucial processes. These bile acids have emerged as significant contributors to managing type 2 diabetes mellitus, complex clinical syndrome primarily driven by insulin resistance. substantially lower blood levels through multiple pathways: BA-FXR-SHP, BA-FXR-FGFR15/19, BA-TGR5-GLP-1, BA-TGR5-cAMP. They also impact regulation intestinal flora, endoplasmic reticulum stress, bitter taste receptors. Collectively, these regulatory mechanisms enhance sensitivity, stimulate secretion, boost expenditure. This review aims comprehensively explore interplay between acid T2DM, focusing on primary pathways. By examining latest advancements our understanding of interactions, we aim illuminate potential therapeutic strategies identify areas for future research. Additionally, this critically assesses current research limitations contribute effective management T2DM.

Language: Английский

---

Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 20, 2024

Inflammatory bowel disease (IBD) is a chronic and recurrent condition affecting the gastrointestinal tract. Disturbed gut microbiota abnormal bile acid (BA) metabolism are notable in IBD, suggesting bidirectional relationship. Specifically, diversity of influences BA composition, whereas altered profiles can disrupt microbiota. IBD patients often exhibit increased primary reduced secondary concentrations due to diminished bacteria population essential for metabolism. This imbalance activates receptors, undermining intestinal integrity immune function. Consequently, targeting microbiota-BA axis may rectify these disturbances, offering symptomatic relief IBD. Here, interplay between acids (BAs) reviewed, with particular focus on role mediating biotransformation, contributions pathology unveil potential novel therapeutic avenues

Language: Английский

---

The Positive Regulatory Effect of DBT on Lipid Metabolism in Postpartum Dairy Cows

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 58 - 58

Published: Jan. 16, 2025

Background/Objectives: The transition from a non-lactating to lactating state is critical period for lipid metabolism in dairy cows. Danggui Buxue Tang (DBT), stimulating energy metabolism, ameliorates diseases related disorders and expected be an effective supplement alleviating excessive mobilisation periparturient This study aimed investigate the effects of supplemental DBT on serum biochemical indices, faecal microbial communities, plasma metabolites Methods: Thirty cows were randomly divided into three groups: H-DBT group, L-DBT control group. administration was started day calving continued once daily seven days. Faecal blood samples collected day, 7 days after calving, 14 calving. levels indices measured at time points groups using commercial kits. Cows group selected metabolome 16S rRNA amplicon sequencing. Results: Our research shows that, postpartum, significantly reduced 3-hydroxybutyric acid (BHB) concentrations number with BHB ≥ 1 mmol/L. Additionally, increased total cholesterol contents both postpartum. Analysis microbiota community showed that modulated composition structure hindgut microbiota. Metabolomic analysis revealed decreased acetylcarnitine, 2-hydroxybutyric acid, whereas TCA cycle enhanced. At altered bile profile, especially glycine-conjugated acids, including GCDCA, GUDCA, GDCA. Correlation analyses relative abundances Bacillus, Solibacillus, Dorea, Romboutsia strongly correlated differential metabolites, which crucial beneficial DBT. Conclusions: improves status postpartum by modulating metabolites.

Language: Английский

---

Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality morbidity rates globally. Shenmai injection (SMI), form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF. Recent research suggests that Medicine (TCM) may induce beneficial changes microbial-host co-metabolism, potentially providing cardiovascular protection. This study used rat model hypertensive heart (H-HF) to explore the mechanism SMI. The possible compounds key targets SMI against H-HF were investigated using network pharmacology. pharmacodynamics validated animal model, with analysis fecal gut microbiota integrating metabolomics 16S rRNA sequencing. Metorigin metabolite traceability MetaboAnalyst platform utilized action mechanism. To evaluate serum TMAO levels, targeted was performed. Finally, looked at intrinsic relationships among modifications intestinal flora, profile changes, clarify how they might be treat H-HF. According sequencing, reestablishing homeostasis microbiota, affects vital metabolic pathways, such as energy metabolism, amino acid bile metabolism. Increased levels identified risk factor for H-HF, able downregulate TMAO-related metabolites. Network pharmacology 13 active components targeting 46 proteins, resulting differential expression 8 metabolites 24 microbes. In conclusion, this highlights alleviating its potential modulate co-metabolism. Through comprehensive discussion interconnected components, targets, metabolites, it provided fresh light on therapeutic Not applicable.

Language: Английский

---

Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases

Medical Review, Journal Year: 2024, Volume and Issue: 4(4), P. 262 - 283

Published: June 3, 2024

Abstract Maintaining bile acid homeostasis is essential for metabolic health. Bile encompasses a complex interplay between biosynthesis, conjugation, secretion, and reabsorption. Beyond their vital role in digestion absorption of lipid-soluble nutrients, acids are pivotal systemic regulation. Recent studies have linked dysregulation to the pathogenesis diseases, including obesity, type 2 diabetes mellitus (T2DM), dysfunction-associated steatotic liver disease (MASLD). signaling molecules that regulate many critical biological processes, lipid metabolism, energy expenditure, insulin sensitivity, glucose metabolism. Disruption contributes via altered feedback mechanisms, hormonal dysregulation, interactions with gut microbiota, changes expression function transporters receptors. This review summarized molecular pathways regulatory mechanisms through which progression T2DM, MASLD. We aim underscore significance as potential diagnostic markers therapeutic agents context providing insights into application translational medicine.

Language: Английский

---

Fermented dietary fiber from soy sauce residue exerts antidiabetic effects through regulating the PI3K/AKT signaling pathway and gut microbiota-SCFAs-GPRs axis in type 2 diabetic mellitus mice

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132251 - 132251

Published: May 9, 2024

Language: Английский

---