Scientometric Analysis of Research on Oral and Gut Microbiota and Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution DOI Open Access

Frank Mayta-Tovalino,

Fran Espinoza-Carhuancho,

M. Cruz

et al.

The Journal of Contemporary Dental Practice, Journal Year: 2025, Volume and Issue: 26(1), P. 86 - 92

Published: March 28, 2025

To perform a scientometric analysis of scientific literature related to microbiota and periodontitis. A search strategy was applied on 21 July 2024, identifying 1,069 papers from 408 different sources. However, nine articles could not be exported SciVal due incomplete metadata. The documents, including 722 articles, 282 reviews, 44 book chapters, among others, showed an annual growth rate 7.53%. Bibliometrix were used for data extraction analysis. total sources, published between 2019 identified. most frequent terms in the research "periodontitis", "oral microbiome", "microbiome", "periodontal disease", "dysbiosis". According Lotka's Law, authors field contributed small number papers. cited journals this "Frontiers Cellular Infection Microbiology", "Journal Oral "Periodontology 2000". Analysis thematic evolution shows increasing intersection topics recent research, reflecting multifaceted nature periodontitis its interaction with variety other health factors. Research is multifaceted, interacts factors, growing research. This study presents detailed review gut periodontitis, notes current developments, gives hints regarding still emerging themes. Its findings may serve continue future guidelines or understand relationship How cite article: Mayta-Tovalino F, Espinoza-Carhuancho Huaman-De la Cruz M, et al. Scientometric Gut Microbiota Periodontitis: Collaborative Networks, Emerging Patterns, Thematic Evolution. J Contemp Dent Pract 2025;26(1):86-92.

Language: Английский

The oral-gut microbiota axis: a link in cardiometabolic diseases DOI Creative Commons
Qian Xu, Wenting Wang, Yiwen Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

Citations

4
Gut–X axis DOI Creative Commons
Lin Xu, Yu Zhang, Xueyan Li

et al.

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Citations

3
Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer DOI Open Access
Camelia Munteanu, Betty Schwartz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

Citations

15
Emergence of Antibiotic-Resistant Porphyromonas gingivalis in United States Periodontitis Patients DOI Creative Commons
Thomas E. Rams,

Jacqueline D. Sautter,

A.J. van Winkelhoff

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1584 - 1584

Published: Nov. 2, 2023

Antibiotic resistance patterns of the major human periodontal pathogen Porphyromonas gingivalis were assessed over a 20-year period in United States. Subgingival P. was cultured pre-treatment from 2193 severe periodontitis patients during three time periods: 1999-2000 (936 patients), 2009-2010 (685 and 2019-2020 (572 patients). The clinical isolates tested for vitro to 4 mg/L clindamycin doxycycline, 8 amoxicillin, 16 metronidazole, with post hoc combination data metronidazole plus amoxicillin. Clindamycin-resistant significantly more prevalent (9.1% patients) (9.3%; 15-fold increase) as compared (0.6%). amoxicillin also increased 0.1% 1.3% 2.8% (28-fold 2019-2020. doxycycline low (≤0.5% prevalence), statistically unchanged, period. These findings are first reveal marked increases 20 years clindamycin-resistant amoxicillin-resistant States patients. Increased antibiotic other periodontitis-associated bacteria threatens efficacy antimicrobial chemotherapy.

Language: Английский

Citations

20
Exploring the presence of oral bacteria in non-oral sites of patients with cardiovascular diseases using whole metagenomic data DOI Creative Commons
Aditi Chopra, Ricardo Franco‐Duarte, Anjale Rajagopal

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 17, 2024

Abstract Cardiovascular diseases (CVDs) encompass various conditions affecting the heart and its blood vessels are often linked with oral microbes. Our data analysis aimed to identify bacteria from other non-oral sites (i.e., gut, arterial plaque cultured blood) that could be CVDs. Taxonomic profiling identified species level compared Human Oral Microbiome Database (HOMD). The in samples were catalogued, their average frequency calculated for each sample. Additionally, filtered by comparison Project (HMP) database. We 17,243 microbial species, of which 410 present HOMD database further denominated as “oral”, found at least one gut sample, but only 221 169 samples, respectively. Of 153 solely oral-associated environments after HMP database, irrespective presence body sites. results suggest a potential connection between specific bacterial occurrence Detecting these patients CVDs help uncover link health general health, including cardiovascular via translocation.

Language: Английский

Citations

9
Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships DOI Creative Commons
Xiaoyu Zhang, Jia Wang, Tingting Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 456 - 456

Published: April 2, 2024

Diabetes mellitus (DM) is a common chronic metabolic disease worldwide. The disturbance of the gut microbiota has complex influence on development DM. Polysaccharides are one type most important natural components with anti-diabetic effects. Gut can participate in fermentation polysaccharides, and through this, polysaccharides regulate improve This review begins by summary sources, effects regulation functions polysaccharides. Then, mechanisms regulating to exert structure–activity relationship summarized. It found that from plants, fungi, marine organisms show great hypoglycemic activities functions. mainly include repairing burrier, reshaping composition, changing metabolites, anti-inflammatory activity immune function, signal pathways. Structural characteristics such as monosaccharide molecular weight, glycosidic linkage, provides reference for exploration

Language: Английский

Citations

8
Hydrogen therapy: recent advances and emerging materials DOI
Zheng Jiang, Mailudan Ainiwaer, Jun Liu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4136 - 4154

Published: Jan. 1, 2024

Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO

Language: Английский

Citations

7
The forgotten link: how the oral microbiome shapes childhood growth and development DOI Creative Commons
Raymond R. Tjandrawinata, Nurlinah Amalia, Yosi Yohanes Putra Tandi

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 7, 2025

Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive physical well-being. Emerging evidence highlights the pivotal role of oral microbiome-a dynamic microbial ecosystem-in influencing nutritional status, immune response, overall systemic health. This review explores intricate interplay between microbiome emphasizing mechanisms such dysbiosis, its impact nutrient absorption, modulation. Disruptions in can lead to malabsorption inflammation, further exacerbating impairments children. Furthermore, potential for microbiome-targeted diagnostics interventions, including probiotics prebiotics, offers novel strategies address stunting. A deeper understanding these interactions may inform innovative diagnostic tools therapeutic interventions aimed at mitigating stunting through Integrating research into prevention efforts could provide valuable insights public improve child particularly resource-limited settings. Future should focus elucidating molecular pathways linking developing personalized that optimize early life.

Language: Английский

Citations

1
Enrichment of Porphyromonas gingivalis in colonic mucosa-associated microbiota and its enhanced adhesion to epithelium in colorectal carcinogenesis: Insights from in vivo and clinical studies DOI Creative Commons

Shunya Motosugi,

Naoki Takahashi,

Shuhei Mineo

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320383 - e0320383

Published: March 25, 2025

Objectives The oral–gut axis is believed to play a role in the pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated transmission oral microbiota gut, disrupting gut microbial balance and creating protumorigenic microenvironment conducive CRC progression. Fusobacterium nucleatum putative periodontal pathogen recognized as specific bacterium that promotes development. However, possible involvement other pathogens poorly understood. This study aimed explore effects ingested on experimental mice elucidate underlying mechanisms. Methods In this study, colitis-induced mouse models were used. orally administered ( Porphyromonas gingivalis Prevotella intermedia ) three times week during period. severity between P. -treated groups was compared. Lumen-associated (LAM) mucosa-associated (MAM) analyzed both human samples. vitro conducted using intestinal epithelial cells mechanisms by which affect Results group exhibited significantly increased compared among azoxymethane/dextran sodium sulfate (AOM/DSS)-induced models. LAM MAM distinct bacterial compositions, enriched more than LAM. adhesion assays revealed had higher adhesive capacity indicated gingipains such capacity. Conclusion MAM, its subsequent potentially involved progression CRC.

Language: Английский

Citations

1
The Oral–Gut Microbiome–Brain Axis in Cognition DOI Creative Commons

Noorul Ain Adil,

Christabel Omo-erigbe,

Hariom Yadav

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 814 - 814

Published: April 3, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.

Language: Английский

Citations

1