The interaction between oral microbiota and gut microbiota in atherosclerosis DOI Creative Commons

Xinsi Li,

Qian Li,

Li Wang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 12, 2024

Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis yet to be fully elucidated. In recent years, studies have exhibited that the onset of AS closely involved with oral and gut microbiota, which may initiate or worsen atherosclerotic processes through several mechanisms. As for how two microbiomes affect AS, existing mechanisms include invading plaque, producing active metabolites, releasing lipopolysaccharide (LPS), inducing elevated levels inflammatory mediators. Considering possible profound connection between effect interaction on initiation progression has been investigated. Findings are microbiota can lead dysbiosis, exacerbate intestinal inflammation. Nevertheless, relevant research not commendably refined concrete review needed. Hence, in this review, we summarize most illustrate an overview current clinical epidemiological evidence support bidirectional AS.

Language: Английский

The oral-gut microbiota axis: a link in cardiometabolic diseases DOI Creative Commons
Qian Xu, Wenting Wang, Yiwen Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

Citations

2
Gut–X axis DOI Creative Commons
Lin Xu, Yu Zhang, Xueyan Li

et al.

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Citations

2
Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer DOI Open Access
Camelia Munteanu, Betty Schwartz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

Citations

10
Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships DOI Creative Commons

Xiaoyu Zhang,

Jia Wang, Tingting Zhang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 456 - 456

Published: April 2, 2024

Diabetes mellitus (DM) is a common chronic metabolic disease worldwide. The disturbance of the gut microbiota has complex influence on development DM. Polysaccharides are one type most important natural components with anti-diabetic effects. Gut can participate in fermentation polysaccharides, and through this, polysaccharides regulate improve This review begins by summary sources, effects regulation functions polysaccharides. Then, mechanisms regulating to exert structure–activity relationship summarized. It found that from plants, fungi, marine organisms show great hypoglycemic activities functions. mainly include repairing burrier, reshaping composition, changing metabolites, anti-inflammatory activity immune function, signal pathways. Structural characteristics such as monosaccharide molecular weight, glycosidic linkage, provides reference for exploration

Language: Английский

Citations

8
Exploring the presence of oral bacteria in non-oral sites of patients with cardiovascular diseases using whole metagenomic data DOI Creative Commons
Aditi Chopra, Ricardo Franco‐Duarte, Anjale Rajagopal

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 17, 2024

Abstract Cardiovascular diseases (CVDs) encompass various conditions affecting the heart and its blood vessels are often linked with oral microbes. Our data analysis aimed to identify bacteria from other non-oral sites (i.e., gut, arterial plaque cultured blood) that could be CVDs. Taxonomic profiling identified species level compared Human Oral Microbiome Database (HOMD). The in samples were catalogued, their average frequency calculated for each sample. Additionally, filtered by comparison Project (HMP) database. We 17,243 microbial species, of which 410 present HOMD database further denominated as “oral”, found at least one gut sample, but only 221 169 samples, respectively. Of 153 solely oral-associated environments after HMP database, irrespective presence body sites. results suggest a potential connection between specific bacterial occurrence Detecting these patients CVDs help uncover link health general health, including cardiovascular via translocation.

Language: Английский

Citations

7
Porphyromonas gingivalis, a bridge between oral health and immune evasion in gastric cancer DOI Creative Commons
Matías Muñoz-Medel, Mauricio P. Pinto,

Lauren Goralsky

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 14, 2024

Porphyromonas gingivalis ( P. ) is a gram-negative oral pathogen associated with chronic periodontitis. Previous studies have linked poor health and periodontitis cancer. Severe cases of periodontal disease can result in advanced periodontitis, leading to tissue degradation, tooth loss, may also correlate higher gastric cancer (GC) risk. In fact, loss an elevated risk However, the clinical evidence for this association remains inconclusive. Periodontitis characterized by inflammation upregulation members Programmed Death 1/PD1 Ligand 1 (PD1/PDL1) axis that leads immunosuppressive state. Given immunosuppression are conditions facilitate progression carcinogenesis, we hypothesize and/or its virulence factors serve as mechanistic link between carcinogenesis/GC progression. We discuss potential impact ’ (gingipains, lipopolysaccharide (LPS), fimbriae) on response immune checkpoint inhibitors GC which part current standard care stage patients.

Language: Английский

Citations

6
Emergence of Antibiotic-Resistant Porphyromonas gingivalis in United States Periodontitis Patients DOI Creative Commons
Thomas E. Rams,

Jacqueline D. Sautter,

A.J. van Winkelhoff

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1584 - 1584

Published: Nov. 2, 2023

Antibiotic resistance patterns of the major human periodontal pathogen Porphyromonas gingivalis were assessed over a 20-year period in United States. Subgingival P. was cultured pre-treatment from 2193 severe periodontitis patients during three time periods: 1999-2000 (936 patients), 2009-2010 (685 and 2019-2020 (572 patients). The clinical isolates tested for vitro to 4 mg/L clindamycin doxycycline, 8 amoxicillin, 16 metronidazole, with post hoc combination data metronidazole plus amoxicillin. Clindamycin-resistant significantly more prevalent (9.1% patients) (9.3%; 15-fold increase) as compared (0.6%). amoxicillin also increased 0.1% 1.3% 2.8% (28-fold 2019-2020. doxycycline low (≤0.5% prevalence), statistically unchanged, period. These findings are first reveal marked increases 20 years clindamycin-resistant amoxicillin-resistant States patients. Increased antibiotic other periodontitis-associated bacteria threatens efficacy antimicrobial chemotherapy.

Language: Английский

Citations

15
Effects of bacterial extracellular vesicles derived from oral and gastrointestinal pathogens on systemic diseases DOI
Han Zhang,

Y. Lin,

Siwei Li

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 285, P. 127788 - 127788

Published: June 1, 2024

Language: Английский

Citations

5
Hydrogen therapy: recent advances and emerging materials DOI
Zheng Jiang, Mailudan Ainiwaer, Jun Liu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4136 - 4154

Published: Jan. 1, 2024

Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO

Language: Английский

Citations

5
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients DOI Creative Commons
Man Zhang, Yiming Zhao,

Abdulrahim Umar

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 4, 2024

Abstract Background The oral cavity is home to various ecological niches, each with its own unique microbial composition. Understanding the communities and gene composition in different niches within of cancer (OC) patients crucial for determining how these populations contribute disease progression. Methods In this study, saliva dental plaque samples were collected from OC. Metagenomic sequencing was employed analyze community classification functional sample groups. Results results study revealed significant differences both function between samples. diversity species found be higher compared that Notably, Actinobacteria enriched OC patients. Furthermore, identified several inter-group differential marker species, including Prevotella intermedia , Haemophilus parahaemolyticus Actinomyces radius Corynebacterium matruchitii Veillonella atypica . Additionally, 1,353 genes annotated into 23 pathways. Interestingly, a correlation observed differentially labeled Herpes simplex virus 1 (HSV-1) infection, which may related occurrence development cancer. Conclusions Significant genetic pathogenic bacteria associated diseases predominantly saliva. identification biomarkers pathways provide insights relationship microbiota

Language: Английский

Citations

4