Synthesis and Evaluation of the Antifungal Sensibility of Novel Thienopyridine 1,2,3-Triazole Derivatives DOI Open Access
Alejandra Ramírez-Villalva, Claudia Cervantes-Rebolledo, Carlos A. González‐González

et al.

Journal of the Mexican Chemical Society, Journal Year: 2024, Volume and Issue: 68(1), P. 113 - 123

Published: Jan. 1, 2024

The family of compounds known as azoles are part most the antimicrobial drugs used for treatment infections. Within this triazoles have been extensively studied pharmacophores with very promising results. In work, four novel trisubstituted 1,2,3-triazole a thienopyridine moiety (1a,b; 2a,b) were synthesized through an azide-enolate 1,3-dipolar cycloaddition. Their cheminformatic properties calculated using simulation software available online such Molinspiration, Molsoft, Osiris Property Explorer, pkCSM, SwissADME, and GUSA. results provided important information which allowed us to consider evaluation antifungal activity these compounds. Therefore, was evaluated in vitro against filamentous fungi, including Aspergillus fumigatus ATCC 16907, Trichosporon cutaneum 28592, Rhizopus oryzae 10329, Mucor hiemalis 8690; well six species yeast from Candida genus; C. albicans 10231, utilis 9226, tropicalis 13803, parapsilosis 22019, glabrata 34138 krusei 14243 sensibility studies suggest that 1b, 2a 2b can be considered candidates complementary biological due exhibited activity. Resumen. La familia de compuestos conocidos como forman parte la mayoría los medicamentos utilizados para el tratamiento infecciones. Dentro este grupo, han sido extensamente estudiados farmacóforos con resultados muy prometedores. En trabajo, se sintetizaron cuatro nuevos 1,2,3-triazoles trisustituidos, que incluyen un anillo tienopiridina en su estructura través una cicloadición del tipo azida-enolato. Sus propiedades quimio informáticas fueron calculadas utilizando programas simulación encontrados línea SwissADME y GUSAR. Los obtenidos presentaron información importante permitió considerar evaluación actividad antifúngica estos compuestos. Por lo tanto, esta fue evaluada cepas hogos filamentosos, incluyendo 8690, así también seis especies levaduras género Candida; 14243. estudios observó 1a, 2a, pueden ser considerados posteriores biológica debido inhibición observada.

The rapid emergence of antifungal-resistant human-pathogenic fungi DOI
Shawn R. Lockhart, Anuradha Chowdhary, Jeremy A.W. Gold

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(12), P. 818 - 832

Published: Aug. 30, 2023

Language: Английский

Citations

126
Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

29
Interplay of Cytokines and Chemokines in Aspergillosis DOI Creative Commons
Jata Shankar, Raman Thakur, Karl V. Clemons

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(4), P. 251 - 251

Published: March 27, 2024

Aspergillosis is a fungal infection caused by various species of Aspergillus, most notably A. fumigatus. This fungus causes spectrum diseases, including allergic bronchopulmonary aspergillosis, aspergilloma, chronic pulmonary and invasive aspergillosis. The clinical manifestations severity aspergillosis can vary depending on individual immune status the specific Aspergillus involved. recognition involves pathogen-associated molecular patterns (PAMPs) such as glucan, galactomannan, mannose, conidial surface proteins. These are recognized pathogen receptors present cells Toll-like (TLR-1,2,3,4, etc.) C-type lectins (Dectin-1 Dectin-2). We discuss roles cytokines in from both perspective human experimental infection. Several chemokines have been implicated response to infection, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), CCR4, CCR17, other interleukins. For example, (ABPA) characterized Th2 Th9 cell-type immunity interleukin (IL)-4, IL-5, IL-13, IL-10. In contrast, it has observed that Th1 Th17 via IFN-γ, IL-1, IL-6, IL-17. activate stimulate production molecules, antimicrobial peptides reactive oxygen species, which aid clearance pathogen. Moreover, they help initiate coordinate response, recruit site promote fungus. Insight into host animal studies may understanding possibly leading harnessing power or cytokine (receptor) antagonists transforming them precise immunotherapeutic strategies. could advance personalized medicine.

Language: Английский

Citations

15
Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease DOI
Nicole Kordana, Angus Johnson, Karen Quinn

et al.

Microbiology and Molecular Biology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

SUMMARY Advances in modern medical therapies for many previously intractable human diseases have improved patient outcomes. However, successful disease treatment outcomes are often prevented due to invasive fungal infections caused by the environmental mold Aspergillus fumigatus . As contemporary antifungal not experienced same robust advances as other therapies, defining mechanisms of A. initiation and progression remains a critical research priority. To this end, World Health Organization recently identified priority pathogen Centers Disease Control has highlighted emergence triazole-resistant isolates. The expansion diversity host populations susceptible aspergillosis complex dynamic genotypic phenotypic call reinvigorated assessment pathobiological drug-susceptibility mechanisms. Here, we summarize recent advancements field discuss challenges our understanding heterogeneity its pathogenesis diverse populations.

Language: Английский

Citations

1
Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections DOI Creative Commons

Yutong Guo,

Zeyuan Mao,

Fang Ran

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2582 - 2582

Published: Nov. 3, 2023

Airway mucus dysfunction and impaired immunological defenses are hallmarks of several lung diseases, including asthma, cystic fibrosis, chronic obstructive pulmonary mostly causative factors in bacterial-biofilm-associated respiratory tract infections. Bacteria residing within the biofilm architecture pose a complex challenge clinical settings due to their increased tolerance currently available antibiotics host immune responses, resulting infections with high recalcitrance rates morbidity mortality. To address these unmet needs, potential anti-biofilm therapeutic strategies being developed effectively control bacterial biofilm. This review focuses on recent advances development application nanoparticulate drug delivery systems for treatment biofilm-associated infections, especially addressing barriers concern accessibility various types nanoparticles used combat biofilms. Understanding obstacles facing biofilms nanoparticle-based approaches combatting may encourage researchers explore promising modalities

Language: Английский

Citations

16
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation DOI
Camila Figueiredo Pinzan, Clara Valero, Patrícia Alves de Castro

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(10), P. 2710 - 2726

Published: Aug. 27, 2024

Language: Английский

Citations

5
Epidemiology and Azole Resistance of Clinical Isolates of Aspergillus fumigatus from a Large Tertiary Hospital in Ningxia, China DOI Creative Commons
Yuting Kang, Qiujie Li, Yao Yao

et al.

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 427 - 439

Published: Feb. 1, 2024

Purpose: The objective of this study was to determine the clinical distribution, in vitro antifungal susceptibility and underlying resistance mechanisms Aspergillus fumigatus ( A. ) isolates from General Hospital Ningxia Medical University between November 2021 May 2023. Methods: Antifungal testing performed using Sensititre YeastOne YO10, with high minimal inhibitory concentrations (MICs) were further confirmed standard broth microdilution assays established by Clinical Laboratory Standards Institute (CLSI) M38-third edition. Whole-Genome Resequencing RT-qPCR azole-resistant strains investigate mechanisms. Results: Overall, a total 276 identified various departments, showing an increasing trend number over past 3 years. Two (0.72%) observed, one which showed overexpression cyp51A, cyp51B, cdr1B, MDR1/2, artR, srbA, erg24A , erg4B but no cyp51A mutation. However, other strain harbored two alterations sequences (L98H/S297T). Therefore, we first described Ningxia, China, reported that has L98H/S297T mutations gene without any tandem repeat (TR) promoter region. Conclusions: This emphasizes importance enhancing attention surveillance particularly those non-TR point or non- mutations, order gain better understanding their prevalence spread Keywords: azole resistance, mutation,

Language: Английский

Citations

4
The immune response of upper and lower airway epithelial cells to Aspergillus fumigatus and Candida albicans-derived β-glucan in Th17 type cytokine environment DOI

Murat Turkbey,

Dilara Karagüzel, Ali Doruk Uzunkaya

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: Feb. 24, 2025

Language: Английский

Citations

0
Deciphering the role of mitochondria in human fungal drug resistance DOI Creative Commons
Yuanyuan Ma, Yachun Zhou,

Tianyuan Jia

et al.

Mycology&#58 An International Journal on Fungal Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: March 10, 2025

Language: Английский

Citations

0
Clinical aspects and recent advances in fungal diseases impacting human health DOI Creative Commons
Livio Pagano, Óscar Fernández

Journal of Antimicrobial Chemotherapy, Journal Year: 2025, Volume and Issue: 80(Supplement_1), P. i2 - i8

Published: March 1, 2025

Abstract Fungal diseases are of growing clinical concern in human medicine as the result changes epidemiology, diversity presentation, emergence new pathogens, difficulties diagnosis and increasing resistance to antifungals current available classes. There is a need for high disease awareness among public healthcare physicians, improvement diagnostic methods development drugs from therapeutic classes with an improved profile. In this article, we will explore some key aspects fungal humans provide general overview important topic.

Language: Английский

Citations

0