Smart Molecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
With
increasing
drug
resistance,
Candida
infections
have
posed
serious
threats
to
public
health.
Photodynamic
therapy
harnesses
light
destroy
pathomycete,
providing
a
smart
strategy
for
combating
of
infections.
However,
due
lack
organelle
targeting
ability
and
bad
extracellular
polymeric
substances
penetrability,
current
photosensitizers
(PSs)
are
far
from
desirable
clean
biofilms
fight
against
resistance.
Herein,
mitochondrion
aggregation‐induced
emission
PS,
LIQ‐TPA‐TZ,
was
developed
the
efficient
photodynamic
treatment
oral
infection.
LIQ‐TPA‐TZ
has
good
singlet
oxygen
hydroxyl
radical
generation
ability,
which
can
efficiently
kill
guilliermondii
(
C.
)
eradicate
biofilm.
It
not
only
causes
mitochondrial
damage
by
disruption
respiratory
chain
oxidative
stress‐related
gene
but
also
inhibits
fungal
adhesion
filamentous
growth
prevent
colonization,
mycelia
biofilm
formation,
is
favorable
eliminating
potential
In
mouse
oropharyngeal
infection
model,
significantly
eliminates
infection,
alleviates
inflammation,
accelerates
mucosal
defect
healing.
This
study
provides
confronting
may
be
Candidate
Clinical Microbiology Reviews,
Journal Year:
2024,
Volume and Issue:
37(2)
Published: April 11, 2024
SUMMARYFungal
infections
are
on
the
rise,
driven
by
a
growing
population
at
risk
and
climate
change.
Currently
available
antifungals
include
only
five
classes,
their
utility
efficacy
in
antifungal
treatment
limited
one
or
more
of
innate
acquired
resistance
some
fungi,
poor
penetration
into
"sequestered"
sites,
agent-specific
side
effect
which
require
frequent
patient
reassessment
monitoring.
Agents
with
novel
mechanisms,
favorable
pharmacokinetic
(PK)
profiles
including
good
oral
bioavailability,
fungicidal
mechanism(s)
urgently
needed.
Here,
we
provide
comprehensive
review
agents,
both
improved
known
mechanisms
actions
new
currently
clinical
development
for
treating
invasive
yeast,
mold
(filamentous
fungi),
PLoS Pathogens,
Journal Year:
2024,
Volume and Issue:
20(3), P. e1012011 - e1012011
Published: March 1, 2024
Candida
auris
is
an
emerging
fungal
pathogen
with
unusual
evolutionary
history—there
are
multiple
distinct
phylogeographic
clades
showing
a
near
simultaneous
transition
from
currently
unknown
reservoir
to
nosocomial
pathogen.
Each
of
these
has
experienced
different
selective
pressures
over
time,
likely
resulting
in
selection
for
genotypes
differential
fitness
or
phenotypic
consequences
when
introduced
new
environments.
We
also
observe
diversification
within
clades,
providing
additional
opportunities
differences.
These
differences
can
have
large
impacts
on
pathogenic
potential,
drug
resistance
profile,
trajectory,
and
transmissibility.
In
recent
years,
there
been
significant
advances
our
understanding
strain-specific
behavior
other
microbes,
including
bacterial
pathogens,
we
opportunity
take
this
strain
variation
into
account
describing
aspects
C
.
biology.
Here,
critically
review
the
literature
gain
insight
at
both
clade
levels
,
focusing
phenotypes
associated
clinical
disease
transmission.
Our
goal
integrate
epidemiological
perspectives
molecular
way
that
would
be
valuable
audiences.
Identifying
between
strains
which
specific
will
crucial
pathogen,
important
caveat
analysis
singular
isolate.
Microbiology Spectrum,
Journal Year:
2024,
Volume and Issue:
12(7)
Published: June 6, 2024
,
initially
identified
in
2009,
has
rapidly
become
a
critical
concern
due
to
its
antifungal
resistance
and
significant
mortality
rates
healthcare-associated
outbreaks.
To
date,
whole-genome
sequencing
(WGS)
five
unique
clades
of
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(4), P. 1036 - 1041
Published: Jan. 22, 2025
Bioactivity-guided
isolation
identified
the
main
antifungal
compounds
produced
by
Acrophialophora
levis
as
new
polyhydroxy-polyketides
acrophialocinol
(1)
and
acrophialocin
(2).
Their
biosynthesis
was
elucidated
heterologous
reconstitution
in
Aspergillus
oryzae
involves
an
α-ketoglutarate-dependent
dioxygenase-catalyzed
α-hydroxylation,
resulting
formation
of
a
tertiary
alcohol
that
is
indispensable
for
activity.
Furthermore,
self-resistance
toward
mediated
conserved
RTA1-like
protein
encoded
acr
biosynthetic
gene
cluster.
British Journal of Dermatology,
Journal Year:
2024,
Volume and Issue:
190(4), P. 585 - 587
Published: Jan. 5, 2024
We
describe
14
cases
of
native
refractory
dermatophytes
caused
by
Trichophyton
indotineae
diagnosed
at
a
hospital
in
China
since
2021,
primarily
the
past
1
year
and
from
same
province.
isolates
were
resistant
to
multiple
antifungals
harboured
Phe397Leu
or
Leu393Ser
substitutions
squalene
epoxidase
enzyme.
Short-term
rapid
emergence
multidrug-resistant
T.
poses
increasing
threats
public
safety
warrants
continued
health
surveillance.
