Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy DOI Creative Commons
Fabio Casciano, Lorenzo Caruso,

Enrico Zauli

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2528 - 2528

Published: Nov. 5, 2024

The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types cancer. Exercise has demonstrated numerous advantages preventing cancer aiding its treatment. However, precise mechanisms behind these effects still not fully understood. To contribute to our comprehension exercise's impact on immunotherapy provide recommendations for future research exercise oncology, we will examine roles underlying immune cells. In addition reducing likelihood developing cancer, also improve effectiveness certain approved anticancer treatments, such as targeted therapy, immunotherapy, radiotherapy. is a pivotal modulator response, thus, it play an emerging important role new immunotherapies. responsible involve regulation intra-tumoral angiogenesis, myokines, adipokines, their associated pathways, metabolism, immunity. Our review assesses potential physical adjuvant/neoadjuvant tool, burden relapse, analyzes molecular predicting favorable adjuvanticity effects.

Language: Английский

Association of killer immunoglobulin-like receptor genotypes and haplotypes with acute lymphoblastic leukemia risk DOI Creative Commons
Jameel Al‐Tamimi, Suliman Yousef Alomar,

Ali Aljuaimlani

et al.

Innate Immunity, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Background Killer immunoglobulin-like receptors (KIRs) are key molecules used by natural killer (NK) cells to interact with target cells. These exhibit extensive genotypic polymorphism which has been associated varying outcomes in immune responses against diseases. This study aimed investigate the relationships between KIR genotypes and haplotypes acute lymphoblastic leukemia (ALL) Saudi patients. Methods A total of 259 subjects including 145 cases 114 healthy controls living Riyadh were genotyped for 16 genes two HLA-C1 -C2 allotypes using PCR-SSP genotyping method. Results significant high frequency inhibitory genes; 2DL1 (OR = 2.4; p < 0.0001) 3DL1(OR 10.87; 0.0068) ALL compared group was observed. In contrast, activating 2DS4 gene significantly higher 0.15, Haplotype analysis shows that BX haplogroup strongly occurrence 4.39; 0.0001). Further combinatory their ligands demonstrated strong statistically protective effect 2DS1-C2 combination from 0.06; 0.0003). Conclusion presents evidence supporting connection certain genotypes, haplotypes, KIR-HLA combinations population. The heightened ( 3DL1) haplotype patients indicates a possible involvement these genetic variability dysfunctional NK context disease.

Language: Английский

Citations

1
T cell landscape in the microenvironment of human solid tumors DOI Creative Commons
Enrico Maggi, Enrico Munari, Nadine Landolina

et al.

Immunology Letters, Journal Year: 2024, Volume and Issue: 270, P. 106942 - 106942

Published: Nov. 1, 2024

Language: Английский

Citations

5
The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes DOI Creative Commons
Tongguo Shi, Huan Zhang, Yueqiu Chen

et al.

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Abstract N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role development and progression of various diseases, including cancer, through its regulation degradation, stabilization, splicing, cap-independent translation. Emerging evidence underscores significant m6A modifications both pro-tumorigenic anti-tumorigenic immune responses. In this review, we provide comprehensive overview examine relationship between regulators cancer Additionally, summarize recent advances understanding how influence tumor responses by directly modulating cells (e.g., dendritic cells, tumor-associated macrophages, T cells) indirectly affecting via mechanisms such as cytokine chemokine regulation, modulation cell surface molecules, metabolic reprogramming. Furthermore, explore potential synergistic effects targeting combination with checkpoint inhibitor (ICI) therapies. Together, review consolidates current knowledge on m6A-mediated immunity, offering insights into deeper these may identify patients who are likely to benefit from immunotherapies.

Language: Английский

Citations

0
Exosome‐Based Vaccines: Pioneering New Frontiers in Combating Infectious Diseases and Cancer DOI
Xuejun Wang, Aixue Li,

Ailing Wang

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Exosomes, small extracellular vesicles with lipid bilayer membranes, play a crucial role in cellular communication and can transfer diverse biological cargo, including proteins, lipids, nucleic acids, from donor to recipient cells. Exosomes possess immunological properties, such as antigen delivery immune activation, along excellent drug capabilities, making them promising candidates for vaccine development. For different diseases, exosome‐based vaccines be designed therapeutic or prophylactic by leveraging immunity humoral immunity. With the emergence of precision medicine, personalized demonstrate exceptional potential. This review systematically introduces sources, biogenesis mechanisms, components exosomes describes their regulatory roles system. Subsequently, preparation, administration, therapy are discussed. Finally, applications clinical trials fields anti‐infection anti‐tumor therapies particularly highlighted, an analysis potential challenges future

Language: Английский

Citations

0
Innate immune cells in acute and chronic kidney disease DOI
Xiao‐Ming Meng, Li Wang, David J. Nikolic‐Paterson

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas DOI Open Access

Kenichiro Ishikawa,

Hiroyuki Suzuki, Tomokazu Ohishi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9190 - 9190

Published: Aug. 24, 2024

CD44 regulates cell adhesion, proliferation, survival, and stemness has been considered a tumor therapy target. possesses the shortest standard (CD44s) variety of variant (CD44v) isoforms. Since expression CD44v is restricted in epithelial cells carcinomas compared to CD44s, promising target for monoclonal antibody (mAb) therapy. We previously developed an anti-CD44v10 mAb, C

Language: Английский

Citations

3
Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy DOI Creative Commons
Fabio Casciano, Lorenzo Caruso,

Enrico Zauli

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2528 - 2528

Published: Nov. 5, 2024

The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types cancer. Exercise has demonstrated numerous advantages preventing cancer aiding its treatment. However, precise mechanisms behind these effects still not fully understood. To contribute to our comprehension exercise's impact on immunotherapy provide recommendations for future research exercise oncology, we will examine roles underlying immune cells. In addition reducing likelihood developing cancer, also improve effectiveness certain approved anticancer treatments, such as targeted therapy, immunotherapy, radiotherapy. is a pivotal modulator response, thus, it play an emerging important role new immunotherapies. responsible involve regulation intra-tumoral angiogenesis, myokines, adipokines, their associated pathways, metabolism, immunity. Our review assesses potential physical adjuvant/neoadjuvant tool, burden relapse, analyzes molecular predicting favorable adjuvanticity effects.

Language: Английский

Citations

0