Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential DOI Open Access
Saikat Mitra, Maniza Muni,

Nusrat Jahan Shawon

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 22

Published: Aug. 18, 2022

Tacrine is a drug used in the treatment of Alzheimer’s disease as cognitive enhancer and inhibitor enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to poor therapeutic efficacy high prevalence detrimental effects. An attempt was made understand molecular mechanisms that underlie tacrine analogues influence over neurotherapeutic activity by focusing on modulation neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, regulatory role gene protein expression, energy metabolism, Ca2+ homeostasis modulation, osmotic regulation. Regardless this, are considered model cholinesterase therapy disease. The variety both structural make-up biological functions these substances main appeal for researchers’ interest them. A new paradigm treating neurological diseases presented this review, which includes strategies disease, well other disorders like Parkinson’s synthesis properties newly identified versatile hybrids. We have also shown may promise experimental systems.

Language: Английский

Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications DOI

Zidan Khan,

Nikhil Nath,

Abdur Rauf

et al.

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 365, P. 110117 - 110117

Published: Aug. 19, 2022

Language: Английский

Citations

146
Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review DOI Creative Commons

Min Shi,

Jingyu Gu, Hanjing Wu

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1158 - 1158

Published: June 13, 2022

Lettuce is one of the most famous leafy vegetables worldwide with lots applications from food to other specific uses. There are different types in lettuce group for consumers choose from. Additionally, an excellent source bioactive compounds such as polyphenols, carotenoids, and chlorophyll related health benefits. At same time, nutrient composition antioxidant between varieties, especially green red types. The benefit consumption depends on its composition, particularly antioxidants, which can function nutrients. benefits rely their biochemical effect when reaching bloodstream. Some components be released matrix altered digestive system. Indeed, bioaccessibility measuring quantity these during digestion, important health-promoting features. Extraction new trends observed necessarily used several application fields. Therefore, this review aims demonstrate nutritional value pharmacological properties. Due bioavailability, consumer will able comprehensively understand choosing a healthier diet. common utilization pattern extracted nutrients also summarized further direction.

Language: Английский

Citations

136
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review DOI Creative Commons
Md. Mominur Rahman, Md. Rezaul Islam, Sheikh Shohag

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1713 - 1713

Published: March 6, 2022

Obesity and diabetes are the most demanding health problems today, their prevalence, as well comorbidities, is on rise all over world. As time goes on, both becoming big issues that have a impact people’s lives. Diabetes metabolic endocrine illness set apart by hyperglycemia glucose narrow-mindedness because of insulin opposition. Heftiness typical, complex, developing overall wellbeing worry has for quite some been connected to significant medical in individuals, things considered. Because wide variety low adverse effects, herbal products an important hotspot drug development. Synthetic compounds not structurally diverse lack drug-likeness properties. Thus, it basic keep exploring possible wellsprings novel drugs. We conducted this review literature searching Scopus, Science Direct, Elsevier, PubMed, Web databases. From 1990 until October 2021, research reports, articles, original articles English presented. It provides top bottom data examination plant-inferred might be utilized against heftiness or potentially hostile treatments. Our expanded comprehension systems activity phytogenic compounds, extra examination, could prompt advancement remedial methodologies diseases. In clinical trials, huge number these food kinds restorative plants, bioactive shown beneficial treatment obesity.

Language: Английский

Citations

123
Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin DOI Open Access
Saikat Mitra,

Mashia Subha Lami,

Tanvir Mahtab Uddin

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112932 - 112932

Published: April 9, 2022

Plant-based phytochemicals are now being used to treat plenty of physiological diseases. Herbal drugs have gained popularity in recent years because their strength, purity, and cheap cost-effectiveness. Citrus fruits contain significant amounts flavanones, which falls the category polyphenols. Flavanones occupy a major fraction total polyphenols present plasma when orange juice is taken highly or moderate states. Narirutin disaccharide derivative available citrus fruits, primarily dihydroxy flavanone. From pharmacological viewpoint, narirutin bioactive phytochemical with therapeutic efficacy. Many experimental researches were published on use narirutin. Anticancer activity, neuroprotection, stress relief, hepatoprotection, anti-allergic antidiabetic anti-adipogenic anti-obesity action, immunomodulation couple primary properties. also has antioxidant, anti-inflammatory activities. The ultimate goal this review provide current scenario research narirutin; make better understanding for potential narirutin, as well its biosynthesis strategies side effects. Extensive literature searches studies undertaken determine properties

Language: Английский

Citations

112
Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability DOI Creative Commons

Joaquim Bié,

Bruno Sepodes, Pedro Fernandes

et al.

Compounds, Journal Year: 2023, Volume and Issue: 3(1), P. 40 - 72

Published: Jan. 5, 2023

Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They widely distributed world and can be found fruits, cereals, tea, coffee, beverages. Due to their structural diversity, polyphenols have many different properties biological effects. resistant acid of gastric tract, very few hydrolysed or absorbed stomach. Significant portions ingested reach large intestine interact with local bacteria, so-called gut microbiota. Epidemiological studies confirm that moderate prolonged intake foods rich could prevent development cancer chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, obesity. The current work aims provide an updated overview on nature occurrence polyphenols, quantification methods, bioaccessibility bioavailability, impact human health, namely through interactions

Language: Английский

Citations

95
Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint DOI Creative Commons
Md. Rezaul Islam, Fahadul Islam, Mohamed H. Nafady

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(7), P. 2165 - 2165

Published: March 27, 2022

Breast cancer (BrCa) is the most common malignancy in women and second significant cause of death from cancer. BrCa one challenging malignancies to treat, it accounts for a large percentage cancer-related deaths. The number cases requiring more effective therapy has increased dramatically. Scientists are looking productive agents, such as organic combinations, prevention treatment because chemotherapeutic agents linked metastasis, resistance drugs, side effects. Natural compounds produced by living organisms promote apoptosis inhibit slowing spread As result, these may delay BrCa, enhancing survival rates reducing deaths caused BrCa. Several natural production while lowering cell proliferation triggering death. compounds, addition therapeutic approaches, efficient potential treating This review highlights demonstrated various studies have anticancer properties cells. Future research into biological anti-BrCa pave way new era treatment, with drugs playing key role improving patient rates.

Language: Английский

Citations

91
Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential DOI Creative Commons
Saikat Mitra,

Rajib Das,

Talha Bin Emran

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 22, 2022

Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in solid mass cells known as tumor or liquid cancer. It leading cause mortality worldwide, and number cancer patients has been increasing at an alarming rate, with estimated 20 million cases expected 2030. Thus, use complementary alternative therapeutic techniques that can help prevent subject increased attention. Garlic, most widely used plant medicinal product, exhibits wide spectrum biological activities, including antibacterial, hypo-lipidemic, antithrombotic, anticancer effects. Diallyl disulfide (DADS) major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated DADS anti-tumor activity against many types gynecological cancers (cervical cancer, ovarian cancer), hematological (leukemia, lymphoma), lung neural skin prostate gastrointestinal tract associated (esophageal gastric colorectal hepatocellular cell line, etc. The mechanisms behind action include epithelial-mesenchymal transition (EMT), invasion, migration. This article aims to review available information regarding anti-cancer potential DADS, well summarize its action, bioavailability, pharmacokinetics from published clinical toxicity studies.

Language: Английский

Citations

84
A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics DOI
Juhaer Anjum, Saikat Mitra,

Rajib Das

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 184, P. 106398 - 106398

Published: Aug. 19, 2022

Language: Английский

Citations

82
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action DOI Open Access
Saikat Mitra, Juhaer Anjum, Maniza Muni

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112877 - 112877

Published: March 31, 2022

Emodin is an anthraquinone derivative found in the roots and bark of a variety plants, molds, lichens. has been used as traditional medication for more than 2000 years still common numerous herbal drugs. plentiful three plant families, including Polygonaceae (Rheum, Rumex, Polygonum spp.), Fabaceae (Cassia Rhamnaceae (Rhamnus, Frangula, Ventilago spp.). Emerging experimental evidences indicate that emodin confers wide range pharmacological activities; special focus was implemented toward neurodegenerative diseases, Alzheimer's disease, Parkinson's cerebral ischemia, anxiety depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical were established support neuroprotection emodin. However, this review highlighted role potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).

Language: Английский

Citations

73
Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far? DOI Creative Commons
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(4), P. 1332 - 1355

Published: Jan. 1, 2024

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs).Numerous studies reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting phosphorylation or ubiquitination of signaling molecules, which further prevents degradation IκB.Additionally, they prevent NF-κB translocation nucleus and pro-inflammatory cytokine production.Polyphenols such as curcumin, resveratrol, pterostilbene had significant inhibitory effects on NF-κB, treating NDs.Recent experimental findings suggest possess wide range pharmacological properties.Notably, much attention has been directed towards their potential therapeutic in NDs Alzheimer's disease (AD), Parkinson's (PD), cerebral ischemia, anxiety, depression, autism, spinal cord injury (SCI).Much preclinical data supporting neurotherapeutic benefits developed.Nevertheless, this study described significance agents, specifically emphasizing impact pathway.This article offers comprehensive analysis involvement NDs, including both clinical perspectives.

Language: Английский

Citations

27