Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

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Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6937 - 6937

Published: June 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Language: Английский

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Divergent Processing of Cell Stress Signals as the Basis of Cancer Progression: Licensing NFκB on Chromatin

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8621 - 8621

Published: Aug. 7, 2024

Inflammation is activated by diverse triggers that induce the expression of cytokines and adhesion molecules, which permit a succession molecules cells to deliver stimuli functions help immune system clear primary cause tissue damage, whether this an infection, tumor, or trauma. During inflammation, short-term changes in secretion strong mediators inflammation occur, while long-term occur specific groups cells. Long-term include cellular transdifferentiation for some types need regenerate damaged tissue, as well death can be detrimental integrity if they remain active beyond boundaries essential function. The transcriptional regulator NFκB enables fundamental gene during development. recurrence malignant disease, cell stress-induced alterations enable growth cancer clones are substantially resistant therapeutic intervention system. A number those due significant defects feedback signal cascades control activity NFκB. Specifically, stress contributes it overrides modules otherwise protect host tissue. involved both suppression promotion cancer, key distinctive feature determines its net effect remains unclear. This paper aims provide answer at least one aspect question, namely mechanism divergent response critical inflammatory general.

Language: Английский

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DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(8), P. 2215 - 2227

Published: June 4, 2024

Language: Английский

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Multi-target approach to Alzheimer’s disease prevention and treatment: antioxidant, anti-inflammatory, and amyloid- modulating mechanisms

Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 1, 2025

Language: Английский

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Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5377 - 5377

Published: May 15, 2024

In recent years, there has been a growing interest in the concept of “gut–brain axis”. addition to well-studied diseases associated with an imbalance gut microbiota, such as cancer, chronic inflammation, and cardiovascular diseases, research is now exploring potential role microbial dysbiosis onset development brain-related diseases. When function intestinal barrier altered by dysbiosis, aberrant immune system response interacts nervous system, leading state “neuroinflammation”. The microbiota–brain axis mediated inflammatory immunological mechanisms, neurotransmitters, neuroendocrine pathways. This narrative review aims illustrate molecular basis neuroinflammation elaborate on gut–brain virtue analyzing various metabolites produced microbiome how they might impact system. Additionally, current will highlight sex influences these mechanisms. fact, hormones brain–gut microbiota at different levels, central enteric one, enteroendocrine cells. A deeper understanding human health disease crucial guide diagnoses, treatments, preventive interventions.

Language: Английский

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A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5906 - 5906

Published: May 28, 2024

Alzheimer's Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, definitive cure or treatment for this debilitating disease remains elusive. A notable characteristic AD oxidative stress, which has been identified as potential therapeutic target. Polyphenols, secondary metabolites plant origin, have attracted attention due to their potent antioxidant properties. Epidemiological studies suggest correlation between consumption polyphenol-rich foods and prevention chronic diseases, including disorders, underscores polyphenols strategy management. Hence, comprehensive review focuses on diverse roles AD, with particular emphasis neuroprotective potential. Scopus, ScienceDirect, Google Scholar were used leading databases study selection, from 2018 late March 2024. Analytical chemistry serves crucial tool characterizing polyphenols, nuanced exploration extraction methods various sources, often employing chemometric techniques holistic interpretation advances field. Moreover, examines current vitro vivo research, aiming enhance understanding polyphenols' role providing valuable insights forthcoming approaches context.

Language: Английский

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Exploring Ubiquitination in Spinal Cord Injury Therapy: Multifaceted Targets and Promising Strategies

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(1)

Published: Jan. 20, 2025

Language: Английский

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Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Introduction Spinal cord injury (SCI) leads to severe inflammation and neuronal damage, resulting in permanent loss of motor sensory functions. Zinc ions have shown potential modulating cellular survival, making them a promising therapeutic approach for SCI. This study investigates the mechanisms zinc ion treatment SCI, focusing on its effects inflammation. Methods We used transcriptomic analysis identify key pathways genes involved inflammatory response mouse model In vitro studies assessed impact inflammation, cell polarization, apoptosis. IKBα expression was evaluated as target ions, both cultured cells vivo . Results Transcriptomic revealed that modulate through IKBα, which inhibits NF-κB activity. , upregulated expression, reducing These results were confirmed SCI model, where also reduced death. Discussion Our findings highlight novel mechanism by regulate upregulating inhibiting activation. suggests applications other conditions, warranting further investigation into their clinical benefits.

Language: Английский

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