Russian Journal of Genetics, Journal Year: 2023, Volume and Issue: 59(9), P. 851 - 868
Published: Sept. 1, 2023
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 26, 2024
Immunological diseases are typically heterogeneous in clinical presentation, severity and response to therapy. Biomarkers of immune often reflect this variability, especially compared their regulated behaviour health. This leads a common difficulty that frustrates biomarker discovery interpretation - namely, unequal dispersion disease expression between patient classes necessarily limits biomarker's informative range. To solve problem, we introduce dataset restriction, procedure splits datasets into classifiable unclassifiable samples. Applied synthetic flow cytometry data, restriction identifies biomarkers otherwise disregarded. In advanced melanoma, finds immune-related adverse event risk after immunotherapy enables us build multivariate models accurately predict immunotherapy-related hepatitis. Hence, augments biomarkers, increases predictive certainty for samples improves incorporating with limited principle can be directly extended any classification task.
Language: Английский
Citations
3
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5775 - 5775
Published: Sept. 27, 2024
Asthma, a complex disease characterized by persistent airway inflammation, remains an urgent global health concern. We explored the critical role of allergic biomarkers and dysregulated immune system in asthma through extensive literature review databases such as Web Science, PubMed, EMBASE, Scopus, Google Scholar. This summarizes growing data on pivotal development evolution asthma. Recent studies have uncovered several that elucidate intrinsic mechanisms individuals with article highlights these biomarkers’ potential predicting onset, assessing its intensity, guiding therapeutic interventions, tracking progression. also explore innovative prospects arising from convergence allergy emphasize for precision medicine approaches. Understanding intertwined heralds new era treatment points to improved individualized modalities.
Language: Английский
Citations
3
International Ophthalmology, Journal Year: 2022, Volume and Issue: 43(4), P. 1405 - 1411
Published: Sept. 7, 2022
Language: Английский
Citations
15
Developmental & Comparative Immunology, Journal Year: 2023, Volume and Issue: 144, P. 104708 - 104708
Published: April 10, 2023
Language: Английский
Citations
7
Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24
Published: Jan. 1, 2024
Language: Английский
Citations
2
Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: 239(11)
Published: June 18, 2024
Sepsis is a systemic inflammatory reaction caused by infection, and severe sepsis can develop into septic shock, eventually leading to multiorgan dysfunction even death. In recent years, studies have shown that mitochondrial damage closely related the occurrence development of sepsis. Recent years seen surge in concern over DNA (mtDNA), as anomalies this material lead cellular dysfunction, disruption aerobic respiration, death cell. review, we discuss latest findings on mechanisms molecular controlling mtDNA release. We also explored connection between misplacement activation. Additionally, propose potential therapeutic targets for treatment.
Language: Английский
Citations
2
The Journal of Immunology, Journal Year: 2023, Volume and Issue: 210(4), P. 389 - 397
Published: Jan. 11, 2023
Abstract Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an immune expressed human granulocytes and monocytes that dampens antimicrobial functions. We previously showed sputum neutrophils from infants with severe respiratory syncytial virus (RSV) bronchiolitis have decreased SIRL-1 surface expression compared blood rapidly lost in vitro activated neutrophils. This led us to hypothesize lose by ectodomain shedding. Here, we developed ELISA measured the concentration of soluble (sSIRL-1) patients RSV hospitalized COVID-19, which are both characterized neutrophilic inflammation. In line our hypothesis, sSIRL-1 was increased plasma serum COVID-19 control serum. addition, show release proteolytic cleavage this diminishes ability inhibit reactive oxygen species production via SIRL-1. Finally, found shedding prevented proteinase 3 inhibition extracellular adherence protein Staphylococcus aureus. Notably, recently PSMα3 S. aureus, suggesting aureus may counteract benefit preserved function conclusion, report released endogenous present vivo.
Language: Английский
Citations
6
European Journal of Immunology, Journal Year: 2023, Volume and Issue: 53(5)
Published: March 25, 2023
Similar to immune cells, non-hematopoietic cells recognize microbial and endogenous threats. Their response these stimuli is dependent on the environmental context. For example, intact intestinal epithelium expresses pattern recognition receptors (PRRs) but should tolerate commensal bacteria, while damaged respond promptly initiate an response. This indicates that possess mechanisms sense context regulate their responses. Inhibitory provide sensing cells. instance, they raise threshold for activation prevent overzealous harmless stimuli. are typically studied hematopoietic several of expressed Here, we review evidence regulation by inhibitory receptors, focusing epithelial endothelial We explain can a wide range signals, including cell-cell adhesion, cell-matrix apoptotic More importantly, various functions activation, proliferation, migration. In conclusion, propose fine tuning or These findings prompt investigate more systematically.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3218 - 3218
Published: Feb. 6, 2023
The Bacillus Calmette-Guérin (BCG) vaccine has been in use for over 100 years. It protects against severe, blood-borne forms of tuberculosis. Observations indicate that it also increases immunity other diseases. mechanism responsible this is trained immunity, an increased response non-specific immune cells repeated contact with a pathogen, not necessarily the same species. In following review, we present current state knowledge on molecular mechanisms process. We seek to identify challenges facing science area and consider application phenomenon managing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Language: Английский
Citations
4
Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 40(2), P. 255 - 267
Published: June 30, 2023
Language: Английский
Citations
4