Role of long non‐coding RNAs in adipogenesis: State of the art and implications in obesity and obesity‐associated diseases DOI Creative Commons
Federica Rey,

Valentina Urrata,

Luisa Gilardini

et al.

Obesity Reviews, Journal Year: 2021, Volume and Issue: 22(7)

Published: Jan. 14, 2021

Summary Obesity is an evolutionary, chronic, and relapsing disease that consists of a pathological accumulation adipose tissue able to increase morbidity for high blood pressure, type 2 diabetes, metabolic syndrome, obstructive sleep apnea in adults, children, adolescents. Despite intense research over the last 20 years, obesity remains today with complex multifactorial etiology. Recently, long non‐coding RNAs (lncRNAs) are emerging as interesting new regulators different lncRNAs have been found play role early late phases adipogenesis be implicated obesity‐associated complications onset. In this review, we discuss most recent advances on adipocyte biology complications. Indeed, more researchers focusing investigating underlying roles these molecular modulators could play. Even if significant number evidence correlation‐based, being differentially expressed specific disease, works now focused deeply analyzing how can effectively modulate pathogenesis onset progression. LncRNAs possibly represent markers useful future both diagnosis prompt clinical management patients obesity.

Language: Английский

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory DOI
Mitsuo Kato, Rama Natarajan

Nature Reviews Nephrology, Journal Year: 2019, Volume and Issue: 15(6), P. 327 - 345

Published: March 20, 2019

Language: Английский

Citations

452
MicroRNAs in kidney injury and disease DOI

Nassim Mahtal,

Olivia Lenoir, Claire Tinel

et al.

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(10), P. 643 - 662

Published: Aug. 16, 2022

Language: Английский

Citations

122
Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects DOI Open Access
Xiandeng Li, Ying Zhang, Xiaodong Xing

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115670 - 115670

Published: Oct. 13, 2023

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant challenges in terms early prevention, clinical diagnosis, and treatment. Consequently, it has emerged as major contributor to end-stage renal disease. The glomerular filtration barrier, composed podocytes, endothelial cells, the basement membrane, plays vital role maintaining function. Disruptions podocyte function, including hypertrophy, shedding, reduced density, apoptosis, can impair integrity resulting elevated proteinuria, abnormal rate, increased creatinine levels. Hence, recent research increasingly focused on injury DN, with growing emphasis exploring therapeutic interventions targeting injury. Studies have revealed that factors such lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, impaired autophagy contribute This review aims summarize underlying mechanisms DN provide an overview current status regarding experimental drugs DN. findings presented herein may offer potential targets strategies for management associated

Language: Английский

Citations

44
Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease DOI
Jia Guo, Zhangsuo Liu, Rujun Gong

et al.

Clinical Science, Journal Year: 2019, Volume and Issue: 133(12), P. 1321 - 1339

Published: June 1, 2019

Abstract Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains leading cause end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It imperative to decipher exact mechanisms underlying DKD identify novel therapeutic targets. Burgeoning evidence indicates that long non-coding RNAs (lncRNAs) are essential for diverse biological processes. However, their roles action remain be defined conditions like DKD. The pathogenesis twofold, so principle treatments. As disease, per se root thus a primary focus therapy. Meanwhile, aberrant molecular signaling parenchymal cells inflammatory may directly contribute Evidence suggests number lncRNAs centrally involved development progression either via direct pathogenic or as indirect mediators some nephropathic pathways, TGF-β1, NF-κB, STAT3 GSK-3β signaling. Some likely serve biomarkers early diagnosis prognosis targets slowing even inducing regression established Here, we elaborated latest support key player In an attempt strengthen our understanding DKD, envisage strategies based on targeting lncRNAs, also delineated potential well efficacy lncRNA preclinical models

Language: Английский

Citations

103
SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway DOI Creative Commons
Jun Xu,

Yujie Deng,

Yi Wang

et al.

Cell Proliferation, Journal Year: 2020, Volume and Issue: 53(2)

Published: Jan. 19, 2020

Abstract Objectives Podocyte injury is a prediction marker of diabetic nephropathy (DN), and AKT/mTOR pathway–mediated inhibition autophagy widely reported to contribute podocyte damage. Recent study stated that sperm‐associated antigen 5 (SPAG5) activated signalling in bladder urothelial carcinoma, indicating SPAG5 might regulate play role Materials methods Apoptosis human podocytes (HPCs) were detected by flow cytometry immunofluorescence (IF). Gene level was assessed Western blot RT‐qPCR. Molecular interactions determined pulldown, RNA immunoprecipitation (RIP), co‐immunoprecipitation (co‐IP), chromatin (ChIP) luciferase reporter assays. Results mRNA protein levels upregulated under high glucose treatment HPCs. Silencing reversed the increase apoptosis decrease glucose–treated Later, we found long non‐coding (lncRNA) antisense RNA1 (SPAG5‐AS1) as neighbour gene SPAG5. Mechanistically, YY1 transcriptionally SPAG5‐AS1 podocytes. acted competitive endogenous (ceRNA) miR‐769‐5p/YY1 axis induce interacted with ubiquitin‐specific peptidase 14 (USP14) leads de‐ubiquitination stabilization protein. Conclusions This revealed inhibited aggravated via SPAG5/AKT/mTOR pathway, SPAG5‐AS1/SPAG5 potential target for alleviation offering new thoughts treatments DN.

Language: Английский

Citations

87
Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy DOI

Ruiqiong Ke,

Yan Wang,

Shihua Hong

et al.

Experimental Cell Research, Journal Year: 2020, Volume and Issue: 396(2), P. 112293 - 112293

Published: Sept. 18, 2020

Language: Английский

Citations

83
Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis DOI Creative Commons

Fangfang Zha,

Xiaolu Qu,

Bo Tang

et al.

Aging, Journal Year: 2019, Volume and Issue: 11(11), P. 3716 - 3730

Published: June 13, 2019

Long non-coding RNAs (lncRNAs) play vital roles in diabetic nephropathy (DN). This research aimed to study the potential role and underlying molecular mechanisms of long RNA MEG3 DN.We found that was upregulated DN vivo vitro could enhance cell fibrosis inflammatory response DN.MEG3 functioned as an endogenous sponge for miR-181a mesangial cells (MCs) via direct targeting Ago2-dependent manner.MiR-181a inhibition promoted MC response.In addition, Egr-1 confirmed a target gene miR-181a.Further investigations verified promotes miR-181a/Egr-1/TLR4 axis vivo.These results provide new insights into regulation between signaling pathway during progression.

Language: Английский

Citations

82
Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression DOI Creative Commons
Xiaoxu Ge, Bojin Xu, Wenwei Xu

et al.

Aging, Journal Year: 2019, Volume and Issue: 11(20), P. 8745 - 8759

Published: Oct. 20, 2019

Diabetic nephropathy (DN) is one of the leading causes end-stage renal diseases worldwide.This study designed to investigate underlying function and mechanism a novel lncRNA GAS5 in progression DN.We found that expression level was decreased type 2 diabetes (T2D) with DN compared patients without DN.Moreover, negatively associated severity DN-related complications.lncRNA inhibited MCs proliferation caused G0/1 phase arrest.lncRNA overexpression alleviated fibrosis-related protein mesangial cells (MCs).The dual-luciferase reporter assay RNA binding immunoprecipitation (RIP) results revealed functions as an endogenous sponge for miR-221 via both directly targeting way Ago2-dependent manner.Furthermore, SIRT1 confirmed target gene miR-221.lncRNA upregulated fibrosis by acting sponge.Finally, we GSA5 suppressed development vivo.Thus, involved sponging contributed lncRNA-directed diagnostics therapeutics DN.

Language: Английский

Citations

82
Long Non-Coding RNAs in Kidney Disease DOI Open Access
Michael Ignarski, Rashidul Islam,

Roman‐Ulrich Müller

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(13), P. 3276 - 3276

Published: July 3, 2019

Non-coding RNA species contribute more than 90% of all transcripts and have gained increasing attention in the last decade. One most recent members this group are long non-coding RNAs (lncRNAs) which characterized by a length 200 nucleotides lack coding potential. However, contrast to simple definition, lncRNAs heterogenous regarding their molecular function—including modulation small protein function, guidance epigenetic modifications role as enhancer RNAs. Furthermore, they show highly tissue-specific expression pattern. These aspects already point towards an important cellular biology imply players development, health disease. This view has been confirmed numerous publications from different fields years raised question whether may be future therapeutic targets human Here, we provide concise overview current knowledge on both glomerular tubulointerstitial kidney

Language: Английский

Citations

80
Research progress on multiple cell death pathways of podocytes in diabetic kidney disease DOI Creative Commons
Can Yang, Zhen Zhang,

Jieting Liu

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 12, 2023

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, failure. The injury death podocytes keys to DKD. Currently, a variety cell modes have been identified in podocytes, including apoptosis, autophagy, endoplasmic reticulum (ER) stress, pyroptosis, necroptosis, ferroptosis, mitotic catastrophe, etc. signaling pathways leading these processes interconnected can be activated simultaneously or parallel. They essential for survival that determine fate cells. With deepening research on mechanism death, more researchers devoted their attention underlying pathologic drug therapy In this paper, we discussed podocyte physiologic role DKD processes. We also provide an overview types specific mechanisms involved each type DKD, as well related targeted methods drugs reviewed. last part discuss complexity potential crosstalk between various which will help improve understanding lay foundation new ideal strategies treatment future.

Language: Английский

Citations

27