Experimental and Molecular Pathology,
Journal Year:
2024,
Volume and Issue:
137, P. 104895 - 104895
Published: May 3, 2024
Lipidome
perturbation
occurring
during
meta-inflammation
is
associated
to
left
ventricle
(LV)
remodeling
though
the
activation
of
NLRP3
inflammasome,
a
key
regulator
chronic
inflammation
in
obesity-related
disorders.
Little
known
about
phosphatidylcholine
(PC)
and
phosphatidylethanolamine
(PE)
as
DAMP-induced
inflammasome.
Our
study
aimed
evaluate
if
systemic
reduction
PC/PE
molar
ratio
can
affect
plasma
levels
cardiovascular
disease
(CVD)
patients
with
insulin
resistance
(IR)
risk.
Forty
from
IRCCS
Policlinico
San
Donato
were
enrolled,
their
blood
samples
drawn
before
heart
surgery.
LV
geometry
measurements
evaluated
by
echocardiography
clinical
data
IR
risk
collected.
PC
PE
quantified
ESI-MS/MS.
Circulating
was
an
ELISA
assay.
results
have
shown
that
CVD
presented
lipid
impairment
species
inversely
levels.
Interestingly,
changes
directly
increased
decrease
plasma,
highlighting
effect
cardiac
response.
In
summary,
be
considered
bioactive
mediators
both
Virology Journal,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Oct. 5, 2023
Abstract
Respiratory
syncytial
virus
(RSV),
a
member
of
the
Pneumoviridae
family,
can
cause
severe
acute
lower
respiratory
tract
infection
in
infants,
young
children,
immunocompromised
individuals
and
elderly
people.
RSV
is
associated
with
an
augmented
innate
immune
response,
enhanced
secretion
inflammatory
cytokines,
necrosis
infected
cells.
Oxidative
stress,
which
mainly
characterized
as
imbalance
production
reactive
oxygen
species
(ROS)
antioxidant
responses,
interacts
all
pathophysiologic
processes
above
receiving
increasing
attention
infection.
A
gradual
accumulation
evidence
indicates
that
ROS
overproduction
plays
important
role
pathogenesis
serves
major
factor
pulmonary
inflammation
tissue
damage.
Thus,
antioxidants
seem
to
be
effective
treatment
for
This
article
reviews
information
on
oxidative
stress
ROS-mediated
cellular
events
during
first
time.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 18, 2023
Micro-
and
nanoplastics
(MNPs)
are
emerging
pollutants
with
scarcely
investigated
effects
on
human
innate
immunity.
If
they
follow
a
similar
course
of
action
as
other,
more
thoroughly
particulates,
MNPs
may
penetrate
epithelial
barriers,
potentially
triggering
cascade
signaling
events
leading
to
cell
damage
inflammation.
Inflammasomes
intracellular
multiprotein
complexes
stimulus-induced
sensors
critical
for
mounting
inflammatory
responses
upon
recognition
pathogen-
or
damage-associated
molecular
patterns.
Among
these,
the
NLRP3
inflammasome
is
most
studied
in
terms
activation
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28838 - e28838
Published: March 28, 2024
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
with
motor
symptoms
like
bradykinesia,
tremors,
and
balance
issues.
The
pathology
recognized
by
progressively
degenerative
nigrostriatal
dopaminergic
neurons
(DANs)
loss.
Its
exact
pathogenesis
unclear.
Numerous
studies
have
shown
that
nucleotide-binding
oligomerization
domain-like
receptor
protein
3
(NLRP3)
contributes
to
the
of
PD.
Previous
demonstrated
over-activation
NLRP3
inflammasome
in
microglia
indirectly
leads
loss
DANs,
which
can
worsen
In
recent
years,
autopsy
analyses
PD
patients
models
revealed
upregulation
expression
within
DANs
activation
sufficient
drive
neuronal
loss,
whereas
microglial
occurs
after
death,
inhibition
intraneuronal
prevents
degeneration
DANs.
this
review,
we
provide
research
evidence
related
as
well
focus
on
possible
mechanisms
neurons,
aiming
new
way
thinking
about
prevention
Experimental and Molecular Pathology,
Journal Year:
2024,
Volume and Issue:
137, P. 104895 - 104895
Published: May 3, 2024
Lipidome
perturbation
occurring
during
meta-inflammation
is
associated
to
left
ventricle
(LV)
remodeling
though
the
activation
of
NLRP3
inflammasome,
a
key
regulator
chronic
inflammation
in
obesity-related
disorders.
Little
known
about
phosphatidylcholine
(PC)
and
phosphatidylethanolamine
(PE)
as
DAMP-induced
inflammasome.
Our
study
aimed
evaluate
if
systemic
reduction
PC/PE
molar
ratio
can
affect
plasma
levels
cardiovascular
disease
(CVD)
patients
with
insulin
resistance
(IR)
risk.
Forty
from
IRCCS
Policlinico
San
Donato
were
enrolled,
their
blood
samples
drawn
before
heart
surgery.
LV
geometry
measurements
evaluated
by
echocardiography
clinical
data
IR
risk
collected.
PC
PE
quantified
ESI-MS/MS.
Circulating
was
an
ELISA
assay.
results
have
shown
that
CVD
presented
lipid
impairment
species
inversely
levels.
Interestingly,
changes
directly
increased
decrease
plasma,
highlighting
effect
cardiac
response.
In
summary,
be
considered
bioactive
mediators
both
