Activation and evasion of inflammasomes during viral and microbial infection

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: Jan. 21, 2025

The inflammasome is a cytoplasmic multiprotein complex that induces the maturation of proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) or pyroptosis by activating caspases, which play critical roles in regulating inflammation, cell death, various cellular processes. Multiple studies have shown key regulator host defence response against pathogen infections. During process pathogenic microbe invasion into cells, host's innate immune system recognizes these microbes inflammasomes, triggering inflammatory responses to clear initiate responses. Moreover, microbial pathogens evolved mechanisms inhibit evade activation inflammasomes. Therefore, we review interactions between viruses with inflammasomes during process, highlight molecular induced infection, corresponding strategies employ activity. Finally, also discuss potential therapeutic for treatment infections via targeting their products.

Language: Английский

---

The Intricate Balance between Life and Death: ROS, Cathepsins, and Their Interplay in Cell Death and Autophagy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4087 - 4087

Published: April 6, 2024

Cellular survival hinges on a delicate balance between accumulating damages and repair mechanisms. In this intricate equilibrium, oxidants, currently considered physiological molecules, can compromise vital cellular components, ultimately triggering cell death. On the other hand, cells possess countermeasures, such as autophagy, which degrades recycles damaged molecules organelles, restoring homeostasis. Lysosomes their enzymatic arsenal, including cathepsins, play critical roles in balance, influencing cell’s fate toward either apoptosis mechanisms of regulated death or autophagy. However, interplay reactive oxygen species (ROS) cathepsins these life-or-death pathways transcends simple cause-and-effect relationship. These elements directly indirectly influence each other’s activities, creating complex web interactions. This review delves into inner workings highlighting pivotal role ROS interplay.

Language: Английский

---

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 5, 2024

Virus infection is one of the greatest threats to human life and health. In response viral infection, host’s innate immune system triggers an antiviral mostly mediated by inflammatory processes. Among many pathways involved, nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has received wide attention in context infection. The NLRP3 intracellular sensor composed three components, including NLRP3, adaptor apoptosis-associated speck-like containing CARD (ASC), cysteine protease caspase-1. After being assembled, can trigger caspase-1 induce gasdermin D (GSDMD)-dependent pyroptosis, promoting maturation secretion proinflammatory cytokines such as interleukin-1 (IL-1β) interleukin-18 (IL-18). Recent studies have revealed that a variety viruses activate or inhibit via particles, proteins, nucleic acids. this review, we present regulatory mechanisms functions upon RNA demonstrate multiple therapeutic strategies target for anti-inflammatory effects

Language: Английский

---

Short-Chain Fatty Acids: Promising Therapeutic Targets for Respiratory Syncytial Virus Infection

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 28, 2025

Language: Английский

---

Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 887 - 902

Published: March 1, 2024

Background: The neurocutaneous disease caused by the reactivation of varicella-zoster virus (VZV) is called herpes zoster (HZ). remains in spinal cord back root after chickenpox disappears. Diminished immune function can reactivate VZV, causing severe neuropathic pain that last for months or even years, leading to postherpetic neuralgia (PHN), which severely affects patient's quality life. Much literature compares various cytokine levels body fluids HZ and PHN patients; however, no studies comprehensively evaluate them. Methods: Cochrane Library, PubMed, Web Science, Medline were screened on patients English language. Healthy individuals selected as control group, standardized mean difference (SMD) between case groups was imputed using a fixed-effects random-effects model expressed 95% confidence interval (CI). Newcastle-Ottawa Scale (NOS) used assess article quality. Results: This meta-analysis included 13 articles with 1373 participants. Compared group had significantly higher interleukin (IL)-4, IL-6, IL-10, Hcy, C-reactive protein (CRP), whereas CD3+ T CD4+ lymphocytes reduced. Additionally, IL-6 IL-1β compared group. Conclusion: provides compelling evidence CRP, IL-1β, IL-4, IL-8, IL-10 are associated genesis development PHN. These markers be improve diagnosis treatment these diseases.Furthermore, making results more convincing, it necessary harmonize sample acquisition techniques analytical methods also require larger, rigorously designed broader subgroups sex/age-matched controls. Keywords: zoster, virus, disease, neuralgia, biomarker

Language: Английский

---

Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116772 - 116772

Published: May 28, 2024

Paeoniflorin (PF), which is the main component of Paeonia lactiflora Pall extract, one traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that protected melanocytes inhibited photodamage through suppression oxidative stress (OS). As OS plays a vital role in progression variety diseases, capacity for to suppress may exert important upon them. However, no review exists on these antioxidant as related various diseases. Therefore, this we summarized involved examining molecular mechanisms PF. Through its inhibit OS, has been shown beneficial several systems including nervous, cardiac/vascular, digestive, respiratory well specific diseases such diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along distal flap necrosis, postoperative adhesions, hearing loss. Such findings provide new insights directions future research directed at development natural treatment clinical

Language: Английский

---

Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro

Journal of Virology, Journal Year: 2024, Volume and Issue: 98(2)

Published: Jan. 16, 2024

Bovine viral diarrhea virus (BVDV) threatens a wide range of domestic and wild cattle population worldwide. BVDV causes great economic loss in industry through its immunosuppression persistent infection. Despite extensive research, the mechanism underlying pathogenesis remains elusive. Our data provide first direct evidence that mitochondria-mediated ferroptosis mitophagy are involved inflammatory responses both biotypes BVDV-infected cells. Importantly, we demonstrate different degrees injury mitochondria may attribute to pathways induced by BVDV. Overall, our findings uncover interaction between infection ferroptosis, which shed novel light on physiological impacts infection, promising therapeutic strategy treat this important infectious disease with worldwide distribution.

Language: Английский

---

Harnessing peroxisome proliferator-activated receptor γ agonists to induce Heme Oxygenase-1: a promising approach for pulmonary inflammatory disorders

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 15, 2024

Abstract The activation of peroxisome proliferator-activated receptor (PPAR)-γ has been extensively shown to attenuate inflammatory responses in conditions such as asthma, acute lung injury, and respiratory distress syndrome, demonstrated animal studies. However, the precise molecular mechanisms underlying these inhibitory effects remain largely unknown. upregulation heme oxygenase-1 (HO-1) confer protective effects, including antioxidant, antiapoptotic, immunomodulatory vitro vivo. PPARγ is highly expressed not only adipose tissues but also various other tissues, pulmonary system. Thiazolidinediones (TZDs) are selective agonists for used antihyperglycemic medications. These observations suggest that could modulate metabolism inflammation. Several studies have indicated may serve potential therapeutic candidates inflammation-related diseases by upregulating HO-1, which turn modulates responses. In system, exposure external insults triggers expression molecules, cytokines, chemokines, adhesion matrix metalloproteinases, reactive oxygen species, leading development diseases. Previous HO-1 protects cells from insults, indicating induction exert inhibiting signaling pathways attenuating TZD-induced well understood. This review aimed elucidate through induce explore how they protect against oxidative

Language: Английский

---

ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 307 - 307

Published: June 30, 2024

Oncolytic virotherapy is expected to provide a new treatment strategy for cancer. Aphrocallistes vastus lectin (AVL) Ca2+-dependent receptor containing the conserved domain of C-type and hydrophobic N-terminal region, which can bind bird’s nest glycoprotein D-galactose. Our previous studies suggested that oncolytic vaccinia virus (oncoVV) armed with AVL gene exerted remarkable replication antitumor effects in vitro vivo. In this study, we found oncoVV-AVL may reprogram metabolism hepatocellular carcinoma cells promote ROS, elevated ROS subsequently promoted viral induced apoptosis. This study will theoretical basis application liver

Language: Английский

---

Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway

International Journal of Oncology, Journal Year: 2025, Volume and Issue: 66(3)

Published: Feb. 11, 2025

Long non‑coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11‑AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, reverse transcription‑quantitative PCR situ hybridization revealed that expression was decreased samples associated with an unfavorable prognosis. overexpression significantly proliferation, migration invasion cells, whereas inhibition had the opposite effects. interacted EGFR inhibit phosphorylation attenuate EGFR/ERK signaling, which turn suppressed tumor suppressor function attenuated by agonist NSC228155. Finally, resveratrol (RSV) inhibited cell invasion, may be RSV‑induced decrease SPT6 homolog, histone chaperone transcription elongation factor protein increase transcript levels. signaling interacting EGFR, thereby delaying progression CRC. ABHD11‑AS1/EGFR/ERK axis a novel therapeutic target for preventing

Language: Английский

---