Fìzìologìčnij žurnal,
Journal Year:
2023,
Volume and Issue:
69(6), P. 120 - 132
Published: Nov. 10, 2023
The
review
summarizes
generalizing
modern
scientific
data
on
the
main
functions
of
protein
HMGB1,
and
its
physiological
pathological
roles.
Amphoterin
is
involved
in
key
processes
that
ensure
functioning
DNA
cell
nucleus
plays
an
important
role
outside
it.
HMGB1
has
been
implicated
many
human
inflammatory
diseases
such
as
sepsis,
ischemic
reperfusion
injury,
neurological
conditions,
cardiovascular
disease,
autoimmune
others.
This
manuscript
describes
structure
discusses
significance
this
alarmin
damage-associated
molecular
patterns,
analyzes
development
inflammation
death.
Special
attention
focused
endotoxemia,
well
signaling
pathways
pathogenesis.
Information
results
studies
possibility
modulating
activity
using
inhibitors
also
considered,
since
understanding
may
be
useful
for
developing
new
therapeutic
strategies
aimed
at
treating
conditions
various
origins.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
39(1-3), P. 162 - 165
Published: June 8, 2023
Over
the
past
decade,
extensive
research
has
been
dedicated
to
understanding
oxidative
cell
death,
specifically
transition
from
oxytosis
ferroptosis.
Oxytosis
was
initially
characterized
in
1989
as
a
calcium-dependent
form
of
nerve
death
induced
by
glutamate.
It
associated
with
intracellular
glutathione
depletion
and
inhibition
cystine
uptake
through
system
xc-,
cystine-glutamate
antiporter.
In
2012,
term
"ferroptosis"
coined
during
compound
screening
that
aimed
selectively
induce
RAS-mutated
cancer
cells.
This
identified
erastin
RSL3
inhibitors
xc-
peroxidase
4
(GPX4),
respectively,
triggering
death.
Subsequently,
gradually
fell
out
frequent
usage,
being
replaced
editorial
provides
narrative
review
significant
findings,
experimental
models,
molecular
players
involved
ferroptosis,
shedding
light
on
its
intricate
mechanisms.
Moreover,
it
discusses
implications
these
findings
various
pathological
conditions,
including
neurodegenerative
disorders,
cancer,
ischemia-reperfusion
disease.
By
summarizing
decade-long
progress
made
this
field,
present
Forum
serves
valuable
resource
for
researchers
aiming
unravel
complex
mechanisms
underlying
explore
potential
therapeutic
interventions.
Antioxid.
Redox
Signal.
39,
162-165.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 14, 2024
Background
The
interaction
between
pyroptosis—a
form
of
programmed
cell
death—and
tumor
immunity
represents
a
burgeoning
field
interest.
Pyroptosis
exhibits
dual
role
in
cancer:
it
can
both
promote
development
and
counteract
by
activating
immune
responses
that
inhibit
evasion
encourage
death.
Current
immunotherapy
strategies,
notably
CAR-T
therapy
checkpoint
inhibitors
(ICIs),
alongside
the
potential
certain
traditional
Chinese
medicinal
compounds,
highlight
intricate
relationship
pyroptosis
cancer
immunity.
As
research
delves
deeper
into
mechanisms
within
therapy,
its
application
enhancing
emerges
as
novel
avenue.
Purpose
This
review
aims
to
elucidate
underlying
pyroptosis,
impact
on
biology,
advancements
research.
Methods
A
comprehensive
literature
was
conducted
across
PubMed,
Embase,
CNKI,
Wanfang
Database
from
inception
study
until
August
22,
2023.
search
employed
keywords
such
“pyroptosis”,
“cancer”,
“tumor”,
“mechanism”,
“immunity”,
“gasdermin”,
“ICB”,
“CAR-T”,
“PD-1”,
“PD-L1”,
“herbal
medicine”,
“botanical
“Chinese
“traditional
“immunotherapy”,
linked
AND/OR,
capture
latest
findings
immunotherapy.
Results
is
governed
complex
mechanism,
with
Gasdermin
family
playing
pivotal
role.
While
promising
for
application,
pyroptosis’s
effect
still
evolving.
Notably,
medicine
ingredients
have
been
identified
inducers,
meriting
further
exploration.
Conclusion
consolidates
current
knowledge
It
reveals
beneficial
factor
immunotherapeutic
landscape,
suggesting
leveraging
developing
treatment
including
those
involving
medicine,
forward-looking
approach
oncology.
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 14, 2025
Protein
lactylation
is
a
new
form
of
post-translational
modification
that
has
recently
been
proposed.
Lactoyl
groups,
derived
mainly
from
the
glycolytic
product
lactate,
have
linked
to
protein
in
brain
tissue,
which
shown
correlate
with
increased
neuronal
excitability.
Ischemic
stroke
may
promote
glycolysis,
leading
lactate
accumulation
tissue.
This
heighten
excitability
by
upregulating
levels,
potentially
triggering
post-stroke
epilepsy.
Although
current
clinical
treatments
for
seizures
advanced
significantly,
approximately
30%
patients
epilepsy
remain
unresponsive
medication,
and
prevalence
continues
rise.
study
explores
mechanisms
epilepsy-associated
death
mediated
metabolism
lactylation.
also
examines
potential
histone
deacetylase
inhibitors
alleviate
modifying
thereby
offering
fresh
perspectives
future
research
into
pathogenesis
treatment
Journal of Translational Internal Medicine,
Journal Year:
2025,
Volume and Issue:
13(1), P. 10 - 32
Published: Feb. 1, 2025
In
the
evolving
landscape
of
cancer
treatment,
strategic
manipulation
regulated
cell
death
(RCD)
pathways
has
emerged
as
a
crucial
component
effective
anti-tumor
immunity.
Evidence
suggests
that
tumor
cells
undergoing
RCD
can
modify
immunogenicity
microenvironment
(TME),
potentially
enhancing
its
ability
to
suppress
progression
and
metastasis.
this
review,
we
first
explore
mechanisms
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
cuproptosis,
along
with
crosstalk
between
these
modalities.
We
then
discuss
how
processes
activate
antigen-presenting
cells,
facilitate
cross-priming
CD8+
T
trigger
immune
responses,
highlighting
complex
effects
novel
forms
on
TME
biology.
Furthermore,
summarize
potential
drugs
nanoparticles
induce
or
inhibit
emerging
their
therapeutic
roles
in
treatment.
Finally,
put
forward
existing
challenges
future
prospects
for
targeting
anti-cancer
Overall,
review
enhances
our
understanding
molecular
biological
impacts
RCD-based
therapies,
providing
new
perspectives
strategies
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: May 8, 2025
Abstract
Copper,
an
essential
micronutrient,
plays
significant
roles
in
numerous
biological
functions.
Recent
studies
have
identified
imbalances
copper
homeostasis
across
various
cancers,
along
with
the
emergence
of
cuproptosis,
a
novel
copper-dependent
form
cell
death
that
is
crucial
for
tumor
suppression
and
therapeutic
resistance.
As
result,
manipulating
levels
has
garnered
increasing
interest
as
innovative
approach
to
cancer
therapy.
In
this
review,
we
first
delineate
at
both
cellular
systemic
levels,
clarifying
copper’s
protumorigenic
antitumorigenic
functions
cancer.
We
then
outline
key
milestones
molecular
mechanisms
including
mitochondria-dependent
independent
pathways.
Next,
explore
cuproptosis
biology,
well
interactions
mediated
by
between
cells
immune
system.
also
summarize
emerging
opportunities
targeting
discuss
clinical
associations
cuproptosis-related
genes.
Finally,
examine
potential
biomarkers
put
forward
existing
challenges
future
prospects
leveraging
Overall,
review
enhances
our
understanding
landscape
cancer,
highlighting
copper-
or
cuproptosis-based
therapies
treatment.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: Dec. 6, 2023
Cell
death
is
a
complex
process
required
to
maintain
homeostasis
and
occurs
when
cells
are
damage
or
reach
end
of
life.
As
research
progresses,
it
apparent
that
necrosis
apoptosis
do
not
fully
explain
the
whole
phenomenon
cell
death.
Therefore,
new
modalities
such
as
autophagic
death,
ferroptosis
have
been
proposed.
In
recent
years,
ferroptosis,
type
non-apoptotic
characterized
by
iron-dependent
lipid
peroxidation
reactive
oxygen
species
(ROS)
accumulation,
has
receiving
increasing
attention.
Ferroptosis
can
be
involved
in
pathological
processes
many
disorders,
ischemia-reperfusion
injury,
nervous
system
diseases,
blood
diseases.
However,
specific
mechanisms
which
participates
occurrence
development
leukemia
still
need
more
deeply
studied.
this
review,
we
present
progress
on
mechanism
its
role
leukemia,
provide
theoretical
basis
strategies
for
diagnosis
treatment
clinical
hematological
Oncology,
Journal Year:
2023,
Volume and Issue:
101(12), P. 786 - 798
Published: Jan. 1, 2023
The
molecular
mechanism
of
high-mobility
group
box
1
(HMGB1)
promoting
the
epithelial-mesenchymal
transition
(EMT)
gastric
cancer
(GC)
has
not
been
known
well.
This
study
aimed
to
explore
clinical
effects
HMGB1
expression
levels
on
clinicopathological
characteristics
patients
with
GC
and
uncover
potential
which
promotes
tumor
progression.The
in
125
were
detected
by
immunohistochemistry
Western
blotting.
Univariate
multivariate
analyses
performed
evaluate
relationship
between
GC.
Stable
overexpression
(over-HMGB1)
knockdown
(sh-HMGB1)
cell
lines
(AGS
MKN-45)
used
determine
activation
TLR4/NF-κB
signaling.
Differences
considered
statistically
significant
at
p
<
0.05
two
sides.HMGB1
is
highly
expressed
tissues
lines.
High
(HR
=
1.89,
95%
CI:
1.44-2.39,
0.001)
was
an
independent
risk
factor
for
overall
survival
Downregulation
resulted
downregulation
TLR4
NF-κB
subunit
(p-p65
p-IκBα)
expression,
whereas
upregulated
led
increased
subunits.
Overexpression
upregulation
EMT-TF
enhances
proliferation
migration
abilities
lines.HMGB1
associated
a
poorer
prognosis
activates
signaling
pathway
promote
EMT
progression
may
be
critical
molecule
prediction
therapeutic
target
Fìzìologìčnij žurnal,
Journal Year:
2023,
Volume and Issue:
69(6), P. 120 - 132
Published: Nov. 10, 2023
The
review
summarizes
generalizing
modern
scientific
data
on
the
main
functions
of
protein
HMGB1,
and
its
physiological
pathological
roles.
Amphoterin
is
involved
in
key
processes
that
ensure
functioning
DNA
cell
nucleus
plays
an
important
role
outside
it.
HMGB1
has
been
implicated
many
human
inflammatory
diseases
such
as
sepsis,
ischemic
reperfusion
injury,
neurological
conditions,
cardiovascular
disease,
autoimmune
others.
This
manuscript
describes
structure
discusses
significance
this
alarmin
damage-associated
molecular
patterns,
analyzes
development
inflammation
death.
Special
attention
focused
endotoxemia,
well
signaling
pathways
pathogenesis.
Information
results
studies
possibility
modulating
activity
using
inhibitors
also
considered,
since
understanding
may
be
useful
for
developing
new
therapeutic
strategies
aimed
at
treating
conditions
various
origins.
