Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Antioxidants, Journal Year: 2019, Volume and Issue: 9(1), P. 21 - 21

Published: Dec. 25, 2019

Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids Cannabis sativa L. CBD non-psychoactive but exerts a number beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. The chemistry pharmacology CBD, as well various molecular targets, cannabinoid receptors other components endocannabinoid system with which it interacts, have been extensively studied. In addition, preclinical clinical studies contributed to our understanding therapeutic potential for many diseases, diseases associated oxidative stress. Here, we review biological effects its synthetic derivatives, focusing on cellular, antioxidant, properties CBD.

Language: Английский

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Cannabidiol Adverse Effects and Toxicity

Current Neuropharmacology, Journal Year: 2019, Volume and Issue: 17(10), P. 974 - 989

Published: June 3, 2019

Currently, there is a great interest in the potential medical use of cannabidiol (CBD), non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred 1970s and intensified recently with many discoveries about endocannabinoid system. Multiple preclinical clinical studies led to FDA-approval Epidiolex®, purified medicine formulated for oral administration treatment infantile refractory epileptic syndromes, by US Food Drug Administration 2018. The World Health Organization considers rescheduling cannabis cannabinoids. around world expanding diseases that lack scientific evidence drug's efficacy. Preclinical also report adverse effects (AEs) toxicity following intake.Relevant reporting CBD's AEs or were identified from PubMed, Cochrane Central, EMBASE through January 2019. Studies defining beneficial included provide balance estimating risk/benefit.CBD not risk-free. In animals, developmental toxicity, embryo-fetal mortality, central nervous system inhibition neurotoxicity, hepatocellular injuries, spermatogenesis reduction, organ weight alterations, male reproductive hypotension, although at doses higher than recommended human pharmacotherapies. Human epilepsy psychiatric disorders reported CBD-induced drug-drug interactions, hepatic abnormalities, diarrhea, fatigue, vomiting, somnolence.CBD has proven therapeutic efficacy serious conditions such as Dravet Lennox-Gastaut syndromes likely be off label physicians other conditions. However, interactions must taken into consideration clinicians prior recommending off-label CBD.

Language: Английский

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Cannabidiol in Anxiety and Sleep: A Large Case Series

The Permanente Journal, Journal Year: 2019, Volume and Issue: 23(1)

Published: Jan. 4, 2019

Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. It does not appear to alter consciousness or trigger a "high." A recent surge scientific publications has preclinical and clinical evidence documenting value for CBD some neuropsychiatric disorders, including epilepsy, anxiety, schizophrenia. Evidence points toward calming effect the central nervous system. Interest as treatment wide range disorders exploded, yet few studies exist psychiatric literature.To determine whether helps improve sleep and/or anxiety population.A large retrospective case series at clinic involving application complaints an adjunct usual treatment. The chart review included monthly documentation quality 103 adult patients.Sleep scores, using validated instruments, baseline after treatment.The final sample consisted 72 adults presenting with primary concerns (n = 47) poor 25). Anxiety scores decreased within first month 57 patients (79.2%) remained during study duration. Sleep improved 48 (66.7%) but fluctuated over time. In this review, was well tolerated all 3 patients.Cannabidiol may hold benefit anxiety-related disorders. Controlled are needed.

Language: Английский

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Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial

American Journal of Psychiatry, Journal Year: 2019, Volume and Issue: 176(11), P. 911 - 922

Published: May 21, 2019

Despite the staggering consequences of opioid epidemic, limited nonopioid medication options have been developed to treat this medical and public health crisis. This study investigated potential cannabidiol (CBD), a nonintoxicating phytocannabinoid, reduce cue-induced craving anxiety, two critical features addiction that often contribute relapse continued drug use, in drug-abstinent individuals with heroin use disorder.This exploratory double-blind randomized placebo-controlled trial assessed acute (1 hour, 2 hours, 24 hours), short-term (3 consecutive days), protracted (7 days after last three daily administrations) effects CBD administration (400 or 800 mg, once for 3 days) on anxiety disorder. Secondary measures participants' positive negative affect, cognition, physiological status.Acute administration, contrast placebo, significantly reduced both induced by presentation salient cues compared neutral cues. also showed significant these 7 final (3-day) exposure. In addition, heart rate salivary cortisol levels. There were no there serious adverse effects.CBD's provides strong basis further investigation phytocannabinoid as treatment option

Language: Английский

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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Sept. 21, 2018

Background: Among the many cannabinoids in cannabis plant, cannabidiol (CBD) is a compound that does not produce typical subjective effects of marijuana. Objectives: The aim present review to describe main advances development experimental and clinical use CBD neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications CBD, especially by Brazilian researchers. Results: shown have anxiolytic, antipsychotic neuroprotective properties. In addition, basic investigations on been carried out context other health conditions, including its potential epilepsy, substance abuse dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, Parkinson. Discussion: an useful promising molecule may help patients number conditions. Controlled trials different neuropsychiatric populations are currently under investigation should bring important answers near future support translation research findings settings.

Language: Английский

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Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

British Journal of Pharmacology, Journal Year: 2019, Volume and Issue: 177(6), P. 1227 - 1240

Published: Dec. 4, 2019

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective the market, brief comparison that in China, as an illustration how individual health supplements increase and decrease popularity regional terms. Recent changes sales patterns, mainly taken from US are summarized selection five newer products, which have not been subject extensive recent review profiled: astaxanthin, carotenoid found red algae, seafood, salmon trout, antioxidant; cannabidiol, non-euphoric marijuana ingredient used mood enhancer for painful/inflammatory conditions; modified extracts ginseng new indications including dementia space travel; monk fruit, non-sugar high intensity sweetener nigella seed, popular food Asian medicine, has experienced extraordinary rise recently. LINKED ARTICLES: article part themed section on Pharmacology Nutraceuticals. To view other articles this visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

Language: Английский

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A Cross-Sectional Study of Cannabidiol Users

Cannabis and Cannabinoid Research, Journal Year: 2018, Volume and Issue: 3(1), P. 152 - 161

Published: July 1, 2018

Introduction: Preclinical and clinical studies suggest that cannabidiol (CBD) found in Cannabis spp. has broad therapeutic value. CBD products can currently be purchased online, over the counter at Cannabis-specific dispensaries throughout most of country, despite fact is generally deemed a Schedule I controlled substance by U.S. Drug Enforcement Administration renounced as dietary supplement ingredient Food Administration. Consumer demand for high growing, but few have examined reasons increasing use. Materials Methods: A self-selected convenience sample (n = 2409) was recruited via an online survey designed to characterize whom, how, why individuals are using CBD. The anonymous questionnaire accessed from October 25, 2017 January 2018. Participants were through social media. Results: Almost 62% users reported treat medical condition. top three conditions pain, anxiety, depression. 36% respondents treats their condition(s) "very well itself," while only 4.3% "not very well." One out every nonserious adverse effect. odds condition 1.44 (95% confidence interval, 1.16-1.79) times greater among nonregular than regular users. Conclusion: Consumers specific therapy multiple diverse conditions-particularly depression, sleep disorders. These data provide compelling rationale further research better understand potential

Language: Английский

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Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(7), P. 989 - 989

Published: July 8, 2019

Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects associated adverse drug events (ADEs) along with the potential pharmacokinetic pharmacodynamic drug–drug interactions (DDIs). Given use among patients complex conditions treatment regimens, as well its expanded use, awareness of safety issues needed. Prescribing information federally approved containing were reviewed. Data on ADEs DDIs extracted summarized. Nearly one-half users experienced ADEs, which displayed a general dose-response relationship. Common include transaminase elevations, sedation, sleep disturbances, infection, anemia. common biological targets implicated metabolism (e.g., CYP3A4/2C19) excretion P-glycoprotein), commonly used medication high. General clinical recommendations reducing substrate doses, monitoring finding alternative therapy should be considered, especially medically patients. both victim perpetrator own ADE profile. These considered risk-benefit assessment consumers made aware

Language: Английский

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Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials

Neuropsychopharmacology, Journal Year: 2020, Volume and Issue: 45(11), P. 1799 - 1806

Published: April 8, 2020

Language: Английский

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Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8870 - 8870

Published: Nov. 23, 2020

Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) the two components found highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects was thought to be responsible for psychotropic cannabis. Numerous anecdotal findings testify therapeutic CBD, which some cases were further supported by research findings. However, data regarding CBD's mechanism action potential abundant omnifarious. Therefore, we review basic molecular with particular focus on its analgesic potential. Moreover, this article describes detailed anti-inflammatory various models, including neuropathic pain, inflammatory osteoarthritis others. The dose route administration-dependent effect reduction hyperalgesia or allodynia, as well production pro cytokines, described depending disease model. clinical applications CBD-containing drugs also mentioned. presented herein unravel what is known about pharmacodynamics provide reader current state-of-art knowledge future perspectives research.

Language: Английский

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