Tauroursodeoxycholic acid inhibits endothelial-mesenchymal transition in high glucose-treated human umbilical vein endothelial cells

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102764 - 102764

Published: Jan. 1, 2025

Language: Английский

Immune and Metabolic Mechanisms of Endothelial Dysfunction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13337 - 13337

Published: Dec. 12, 2024

Endothelial dysfunction is a strong prognostic factor in predicting the development of cardiovascular diseases. Dysfunctional endothelium loses its homeostatic ability to regulate vascular tone and prevent overactivation inflammation, leading dysfunction. These functions are critical for homeostasis arterial pressure control, disruption which may lead hypertension. Hypertension itself can also cause endothelial dysfunction, as cells susceptible haemodynamic changes. Although it unclear those factors appear first, they create vicious circle further damaging multiple organs, including heart vessels. There sex-specific differences regarding vessel regulation, contribute blood between men women. Even more importantly, there sex-differences remodelling. Hence, an understanding mechanisms contribution pathological remodelling during hypertension importance. This review addresses immunological metabolic aspects resulting with respect hypertension, potential role differences.

Language: Английский

Advances in regulating endothelial-mesenchymal transformation through exosomes

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 31, 2024

Endothelial-mesenchymal transformation (EndoMT) is the process through which endothelial cells transform into mesenchymal cells, affecting their morphology, gene expression, and function. EndoMT a potential risk factor for cardiovascular cerebrovascular diseases, tumor metastasis, fibrosis. Recent research has highlighted role of exosomes, mode cellular communication, in regulation EndoMT. Exosomes from diseased tissues microenvironments can promote EndoMT, increase permeability, compromise vascular barrier. Conversely, exosomes derived stem or progenitor inhibit preserve By modifying exosome membranes contents, we harness advantages as carriers, enhancing targeting ability to This review aims systematically summarize by different disease contexts provide effective strategies exosome-based intervention.

Language: Английский