Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1659 - 1659

Published: Jan. 14, 2023

Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative typically characterized by memory loss, personality changes, and decline in overall cognitive function. Usually manifesting individuals over the age of 60, this most prevalent type dementia remains fifth leading cause death among Americans aged 65 older. While development effective treatment prevention for AD major healthcare goal, unfortunately, therapeutic approaches to date have yet find plan that produces long-term improvement. Drugs may be able slow down progression rate are being introduced market; however, there has been no previous solution preventing or reversing disease-associated decline. Recent studies identified several factors contribute severity disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, toxins. Thus, increasing evidence supports dietary other lifestyle changes as potentially ways prevent, slow, reverse progression. Studies also demonstrated personalized, multi-therapeutic approach needed improve metabolic abnormalities AD-associated These suggest effects abnormalities, such insulin resistance, chronic inflammation, hypovitaminosis D, hormonal hyperhomocysteinemia, process. Therefore program based on an individual's genetics biochemistry preferable single-drug/mono-therapeutic approach. This article reviews these strategies identify attenuate all risk specific each affected individual. systematically incorporated multiple target numerous simultaneously treat We included high-quality clinical trials observational focused programs comprising physical, activity, well nutritional aspects. Articles from PubMed Central, Scopus, Google Scholar databases were collected, abstracts reviewed relevance subject matter. Epidemiological, pathological, toxicological, genetic, biochemical concluded represents complex network insufficiency. The research explored manuscript confirm need multifactorial various AD. A single-drug delay loss but, date, not prevented reversed it. Diet, physical environment disease, and, therefore, multi-factorial optimization support function offers rational strategy. targets underlying more than mono-therapeutic

Language: Английский

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Dietary Patterns and Alzheimer’s Disease: An Updated Review Linking Nutrition to Neuroscience

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3204 - 3204

Published: July 19, 2023

Alzheimer's disease (AD) is a growing concern for the aging population worldwide. With no current cure or reliable treatments available AD, prevention an important and area of research. A range lifestyle dietary patterns have been studied to identify most effective preventive changes against AD related dementia (ADRD) pathology. Of these, are Mediterranean, DASH, MIND, ketogenic, modified Mediterranean-ketogenic diets. However, there discrepancies in reported benefits among studies examining these patterns. We herein compile narrative/literature review existing clinical evidence on association with ADRD symptomology contemplate their preventive/ameliorative effects neuropathology various milieus. By large, plant-based found be relatively consistently positively correlated preventing reducing odds ADRD. These impacts stem not only from direct impact specific components within brain but also indirect through decreasing deleterious risk factors, such as diabetes, obesity, cardiovascular diseases. Importantly, other psychosocial factors influence intake, social connection, which may directly diet lifestyle, thereby impacting risk. To this end, prospective research should include holistic approach, including considerations.

Language: Английский

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Nuts: Natural Pleiotropic Nutraceuticals

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3269 - 3269

Published: Sept. 19, 2021

Common nuts (tree and peanuts) are energy-dense foods that nature has gifted with a complex matrix of beneficial nutrients bioactives, including monounsaturated polyunsaturated fatty acids, high-quality protein, fiber, non-sodium minerals, tocopherols, phytosterols, antioxidant phenolics. These nut components synergize to favorably influence metabolic vascular physiology pathways, ameliorate cardiovascular risk factors improve prognosis. There is increasing evidence positively impact myriad other health outcomes as well. Nut consumption correlated lower cancer incidence mortality, decreased all-cause mortality. Favorable effects on cognitive function depression have also been reported. Randomized controlled trials consistently show cholesterol-lowering effect. confers modest improvements glycemic control, blood pressure (BP), endothelial function, inflammation. Although foods, they do not predispose obesity, in fact may even help weight loss. Tree peanuts, but peanut butter, generally produce similar positive outcomes. First level from the PREDIMED trial shows that, context Mediterranean diet, 30 g/d (walnuts, almonds, hazelnuts) significantly lowered composite endpoint major adverse events (myocardial infarction, stroke, death disease) by ≈30% after intervention for 5 y. Impressively, nut-supplemented diet reduced stroke 45%. As rich salutary bioactive compounds beneficially various outcomes, can be considered natural pleiotropic nutraceuticals.

Language: Английский

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Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3728 - 3728

Published: Oct. 22, 2021

New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from interventions is mainly food and nutrient supplement interventions, with inconsistent results high heterogeneity between trials. We conducted a comprehensive systematic search randomized controlled trials (RCTs) published in MEDLINE-PubMed, January 2018 to July 2021, investigating impact counseling, as well food-based on function adults or without impairment. Based strategy, 197 eligible publications were used data abstraction. Finally, 61 articles included analysis. There was reasonable that patterns, supplements improved domains measures brain integrity. The Mediterranean diet showed promising results, whereas role DASH not clear. Healthy consumption function, although quality these studies relatively low. mixed, strong benefits polyphenols combinations nutrients, but low PUFAs, vitamin D, specific protein, amino acids, other types supplements. Further well-designed RCTs needed guide development

Language: Английский

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Consumption of Nuts and Seeds and Health Outcomes Including Cardiovascular Disease, Diabetes and Metabolic Disease, Cancer, and Mortality: An Umbrella Review

Advances in Nutrition, Journal Year: 2022, Volume and Issue: 13(6), P. 2136 - 2148

Published: Aug. 30, 2022

Consumption of nuts and seeds is associated with a range health outcomes. Summarizing the best evidence on essential outcomes from consumption to provide optimal recommendations. Our objective comprehensively assess outcome associations related seeds, using culinary definition including tree peanuts (registered in PROSPERO: CRD42021258300). Health interest include cardiovascular disease, cancer, diabetes, obesity, respiratory mortality, their disease biomarkers. We present for high compared low consumption, per serving, dose–response relations. MEDLINE, Embase, Cochrane, Epistemonikos were searched screened systematic reviews meta-analyses. Evidence was extracted 89 articles relevant outcomes, 23 meta-analysis 66 biomarkers 9 allergy/adverse Intake reduced risk diseases factors, moderate quality evidence. An intake 28 g/d not eating 21% RR reduction (including coronary heart incidence atrial fibrillation, stroke mortality), an 11% cancer deaths, 22% all-cause mortality. Nut also inversely mortality diseases, infectious diabetes; however, between nut diabetes mixed. Meta-analyses trials generally mirrored meta-analyses observational studies cancers, diabetes. Allergy adverse reactions observed 1–2% adult populations, substantial heterogeneity studies. Overall, current supports dietary recommendations consume handful day people without allergies these foods.

Language: Английский

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Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(2), P. 333 - 333

Published: Jan. 13, 2022

Background: This narrative review presents the association between metabolic syndrome (MetS), along with its components, and cognition-related disorders, as well potential reversal role of diet against cognitive impairment by modulating MetS. Methods: An electronic research in Medline (Pubmed) Scopus was conducted. Results: MetS decline share common cardiometabolic pathways components can trigger impairment. On other side, risk factors for both be reduced optimizing nutritional intake. Clinical manifestations such dyslipidemia, hypertension, diabetes increased central body adiposity are nutrition-related present during prodromal period before The Mediterranean dietary pattern stands among most discussed predominantly plant-based diets relation to disorders that may prevent dementia, Alzheimer’s disease disorders. In addition, accumulating evidence suggests consumption specific food groups a part overall improve outcomes, maybe due their involvement paths. Conclusions: Early detection helpful or delay decline. Moreover, this highlights importance healthy habits reverse conditions urgency early lifestyle interventions.

Language: Английский

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Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Cognitive Function and its Decline: A Prospective Study and Meta-analysis of Cohort Studies

American Journal of Clinical Nutrition, Journal Year: 2023, Volume and Issue: 118(1), P. 174 - 182

Published: April 25, 2023

Language: Английский

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Health Benefits Related to Tree Nut Consumption and Their Bioactive Compounds

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 5960 - 5960

Published: May 31, 2021

Long-term studies with regular tree nut consumption have indicated positive outcomes for multiple health benefits. Here, we review the beneficial effects of nuts, highlighting impact on glucose modulation, body weight management, cardiovascular risk, inflammation, oxidative stress, cognitive performance, and gut microbiota. Nuts are important sources nutrients phytochemicals, which, together a healthy lipid profile, could help prevent certain chronic diseases, protect against stress improve thus reducing aging neurodegeneration.

Language: Английский

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Role of Probiotics and Diet in the Management of Neurological Diseases and Mood States: A Review

Microorganisms, Journal Year: 2022, Volume and Issue: 10(11), P. 2268 - 2268

Published: Nov. 15, 2022

Alzheimer’s (AD) and Parkinson’s diseases (PD) are common in older people. Autism spectrum disorders (ASD), anxiety, depression, stress, cognitive impairment prevalent among people irrespective of age. The incidence neurological has been increasing recent decades. Communication between the gut microbiota brain is intrinsically complicated, it necessary for maintenance gut, brain, immune functions host. bidirectional link designated as “microbiota–gut–brain axis.” Gut modulates host system tissue barriers such mucosa blood–brain barrier (BBB). microbial dysfunction disturbs gut–brain interplay may contribute to various disorders, neurocognitive psychiatric disorders. Probiotics could protect intestinal integrity, enhance functions, promote mucosal BBB support synthesis brain-derived neurotrophic factors, which neuronal survival differentiation. be considered an adjunct therapy manage metabolic diseases. Predominantly, Lactobacillus Bifidobacterium strains documented potent probiotics, help maintain interactions brain. consumption probiotics containing fermented foods improve microbiota. diet impacts microbiota, a balanced integrity communication by facilitating production factors other neuropeptides. However, beneficial effects might depend upon several including strain, dosage, duration, age, physiology, etc. This review summarizes importance involvement neuroprotection managing representative injuries mood states.

Language: Английский

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Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial

Clinical Nutrition, Journal Year: 2021, Volume and Issue: 40(11), P. 5556 - 5567

Published: Sept. 21, 2021

Language: Английский

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