Telomere Attrition in Chronic Kidney Diseases

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 579 - 579

Published: Feb. 25, 2023

Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes where they maintain genomic stability. Due to replication problem, telomeres shorten with each cell division. Critically short trigger cellular senescence, which contributes various degenerative and age-related diseases, including chronic kidney diseases (CKDs). Additionally, other factors such as oxidative stress may also contribute accelerated telomere shortening. Indeed, highly susceptible damage due their high guanine content. Here, we provide a comprehensive review studies examining length (TL) in CKDs highlight association between TL development progression humans. We then focus on investigating patients receiving replacement therapy. The mechanisms relationship CKD not fully understood, but shorter has been associated decreased function nephropathy. Interestingly, lengthening observed some longitudinal studies. Hemodialysis shown accelerate erosion, whereas uremic milieu is reversed even transplantation patients. Overall, this aims insights into biological significance attrition pathophysiology disease, new strategies for management CKDs.

Language: Английский

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GLIS1 alleviates cell senescence and renal fibrosis through PGC1-α mediated mitochondrial quality control in kidney aging

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 209, P. 171 - 184

Published: Oct. 16, 2023

Mitochondrial dysfunction is implied as a crucial factor in age-related chronic kidney disease. It confirmed that Gli-like transcription 1 (GLIS1) involved renal fibrosis, however, the correlation between mitochondrial disturbances and GLIS1-driven aging are not clearly clarified. Thus, we investigated regulatory mechanism of GLIS1 homeostasis quality control both vivo vitro. The lower expression was identified natural accelerated aged models, accompanied by dysfunctions control, including enhanced fission, reduced biogenesis mitophagy, whereas, could maintain stability interacting with peroxisome proliferator-activated receptor γ coactivator-1α (PGC1-α). Additionally, over-expressed inhibited extracellular matrix accumulation alleviated fibrosis while siGLIS1 PGC1-α transcription, well affecting its mitochondria-protective functions. Collectively, demonstrated mediated through targeting aging, which might be promising therapeutic target for attenuating cell senescence fibrosis.

Language: Английский

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Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Nov. 29, 2023

Cognitive impairments, such as learning and memory deficits, may occur in susceptible populations including the elderly patients who are chronically ill or have experienced stressful events, surgery, infection, trauma. Accumulating lines of evidence suggested that peripheral inflammation featured by recruitment immune cells release pro-inflammatory cytokines be activated during aging these conditions, participating system-brain communication. Lots progress has been achieved deciphering core bridging mechanism connecting cognitive which helpful developing early diagnosis, prognosis evaluation, prevention methods based on blood circulation system sampling intervention. In this review, we summarized evolving prevalence inflammation-associated neurocognitive impairments discussed research advances underlying mechanisms. We also highlighted treatment strategies against dysfunction.

Language: Английский

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Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007–2016

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(2), P. 637 - 637

Published: Jan. 13, 2023

(1) Background: Preclinical and clinical studies on the anti-aging effect of α-Klotho are emerging. Urinary albumin excretion (UAE) is a well-known biomarker kidney injury generalized damage in cardiovascular system. However, potential relationship between UAE limited controversial. This study aimed to quantify this general middle-aged elderly population from National Health Nutrition Survey (NHANES) 2007-2016. (2) Methods: Serum was measured by enzyme-linked immunosorbent assay. assessed albumin-to-creatinine ratio (ACR). After adjusting for several confounding variables, ACR analyzed weighted multivariable logistic regression, subgroup analysis, interaction tests. A additive model (GAM) with smooth functions using two-piecewise linear regression used examine nonlinear ACR. (3) Results: Among 13,584 participants aged 40-79 years, we observed an independent significant negative correlation (β = -12.22; 95% CI, -23.91, -0.53, p 0.0448) especially those age ≥ 60 pulse pressure (PP) mmHg, hypertension or diabetes. We further discovered GAM, revealing first then positive correlations inflection point 9.91 pg/mL (4) Conclusions: dose-response demonstrated, therein indicated that has as serum marker prophylactic therapeutic agent despite its metabolic effective mechanisms needing be explored.

Language: Английский

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Association of long-term remnant cholesterol with the incidence of chronic kidney disease in a high-risk population

HORMONES, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

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Effect of dietary protein intake on cognitive function in the elderly with chronic kidney disease: analysis of the National Health and Nutrition Examination Survey 2011–2014

Renal Failure, Journal Year: 2023, Volume and Issue: 45(2)

Published: Dec. 14, 2023

Cognitive dysfunction is prevalent among the elderly diagnosed with chronic kidney disease (CKD). Low protein diets are used for retarding progression of CKD in clinical practice. Nonetheless, impact dietary consumption on cognitive function this population remains uncertain.We recruited 2306 participants (≥60 years) from 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). 24-h recall questionnaire was utilized evaluate intake. measured using Consortium Establish a Registry Alzheimer's Disease (CERAD), Animal Fluency Test (AFT), Digit Symbol Substitution (DSST). Participants' characteristics were analyzed, interaction between impairment analyzed logistic regression model.We divided into three groups based stages: no CKD, stage G1 G2 (19%), G3 G5 (18%). The average intake 0.97 g/(kg·d). In higher group, stages elevated risk immediate memory (OR: 2.441, 95% Cl: 1.161-5.132 1.0-1.2g/(kg·d); OR: 2.225, 1.015-4.876 >1.2 g/(kg·d)). However, similar resuts observed lower group. addition, status statistically significant (p = .041).A probability early-stage may be linked potential strategy release CKD.

Language: Английский

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Association of nocturia of self-report with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005–2018

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 25, 2023

Nocturia is a manifestation of systemic diseases, in which chronic kidney disease (CKD) an independent predictor nocturia due to its osmotic diuretic mechanism. However, our knowledge, previous studies have not examined the association between and estimated glomerular filtration rate (eGFR). The purpose this study was assess exposure eGFR general US population. This presents cross-sectional analysis population enrolled National Health Nutrition Examination Survey (NHANES) from 2005 2018. To account for potential confounding factors, linear regression conducted investigate eGFR. Stratified analyses interaction tests were employed examine variables interest. Additionally, sensitivity across diverse populations. A total 12,265 individuals included study. After controlling results indicated that single increase nocturnal voiding frequency associated with decrease by 2.0 mL/min/1.73 m2. In comparison urinary 0, those who voided 1, 2, 3, 4, ≥ 5 times at night experienced 3.1, 5.4, 6.4, 8.6 4.0 m2, respectively. found be decreased 4 m2 when compared without nocturia. yielded consistent findings regarding both CKD non-CKD populations, as well hypertensive non-hypertensive Nevertheless, inconsistent conclusions observed various prognostic risk populations within context. presence heightened urination been decline

Language: Английский

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Unveiling the geriatric dimensions of chronic kidney disease

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(6)

Published: June 1, 2023

Language: Английский

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Inverse association between caffeine intake and albuminuria in US adults: an analysis of NHANES 2005-2016

Acta Clinica Belgica, Journal Year: 2023, Volume and Issue: 78(6), P. 438 - 445

Published: June 6, 2023

Albuminuria is a significant biomarker of various kidney diseases and associated with renal outcome. Recently, caffeine intake has shown potential renoprotective effects. However, the relationship between albuminuria remains profoundly elusive.We conducted cross-sectional study aimed to explore association in American adult population using data acquired from National Health Nutrition Examination Survey (NHANES) 2005-2016. Caffeine was assessed by 24-h dietary recalls, albumin-to-creatinine ratio. Multivariate logistic regression performed independent albuminuria. Subgroup analysis interaction tests were also conducted.Among 23,060 participants, 11.8% individuals exhibited albuminuria, prevalence decreased higher tertiles (Tertile 1: 13%; Tertile 2: 11.9%; 3: 10.5%; P < 0.001). After adjusted confounders, results indicated that risk (OR = 0.903; 95% CI: 0.84, 0.97; 0.007), especially females participants aged <60 years chronic disease stage II.The present first an inverse correlation which further confirmed potentially protective effects on kidney.

Language: Английский

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Association of nocturia with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005-2018

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 17, 2022

Abstract Background Nocturia is a manifestation of systemic disease, which chronic kidney disease an independent predictor nocturia because its osmotic diuretic mechanism. However, to our knowledge, previous studies have not examined the relationship between and eGFR. Objective The purpose this study was assess association exposure eGFR in general US population. Methods Our cross-sectional examination 12,265 regular Americans who took part rvey NHANES 2005 2018. After controlling for gender, age, race, fasting blood glucose, glycosylated hemoglobin, ALT, AST, TG, CHOL, HDL, LDL, BMI, diabetes, hypertension, alcohol consumption, tobacco use PHQ9 score, multiple regression analysis performed determine Covariate-specific hierarchical interaction testing were performed. A sensitivity then conducted CKD group, non-CKD various prognostic risk groups. Results Multiple showed that frequency increased by 1 time, decreased 2.0 mL/min/1.73m 2 (95%CI: -2.4, -1.7). Compared with no nocturia, decrease most significant 4 times per night -10.7, -5.4). results remained stable Within all groups, only moderately low-risk groups had comparable results. Conclusions Increased associated eGFR, regardless diagnosis CKD. correlation observed very high

Language: Английский

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