Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review DOI Creative Commons
Alicja Ewa Ratajczak, Stefano Festa, Annalisa Aratari

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 10, 2023

Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate diet play a role in the risk developing course IBD. It is known group beneficial bacteria was reduced IBD Mediterranean (MD)-which defined as eating habits characterized by high consumption plant foods, mainly cereals, vegetables, fruit well olive oil, small portions dairy products, sweets, sugar meat products-affects gut microbiota, enriching bacteria, which support barrier function reduce inflammation. Although several different favorable effects MD on IBD, adherence to patients generally low, including Basin. Patients avoid many products elements because there gastrointestinal symptoms. should be encouraged have healthy well-balanced according individual tolerance products. A good option seems modified MD, changing hard-to-digest easy digest.

Language: Английский

Gut microbiota and its metabolites in depression: from pathogenesis to treatment DOI Creative Commons
Lanxiang Liu, Haiyang Wang, Xueyi Chen

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104527 - 104527

Published: March 22, 2023

Language: Английский

Citations

293
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

Citations

255
Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease DOI Open Access

Yoonhwa Shin,

Sunhee Han,

Juhui Kwon

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

Citations

76
Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications DOI Creative Commons
Sonia Facchin, Luisa Bertin, Erica Bonazzi

et al.

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 559 - 559

Published: April 26, 2024

The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such dietary fibers. Through fermentation these food components, short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced, offering numerous health benefits host. production absorption SCFAs occur through various mechanisms within human intestine, contingent upon types fibers reaching specific engaged fermentation. Medical literature extensively documents supplementation SCFAs, particularly butyrate, treatment gastrointestinal, metabolic, cardiovascular, gut-brain-related disorders. This review seeks provide an overview dynamics involved gut. Additionally, it will focus on roles promoting metabolic health, well their current therapeutic implications.

Language: Английский

Citations

56
Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes DOI
Yoshitaka Hashimoto, Fuyuko Takahashi, Takuro Okamura

et al.

Metabolism, Journal Year: 2023, Volume and Issue: 144, P. 155585 - 155585

Published: May 6, 2023

Language: Английский

Citations

46
Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications DOI Creative Commons

Junzhe Cheng,

Hongkun Hu, Yumeng Ju

et al.

General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101374 - e101374

Published: Feb. 1, 2024

The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing microbiota-gut-brain axis, its metabolites regulate central nervous system through neural, endocrine immune pathways to ensure normal functioning of organism, tuning individuals’ health disease status. Short-chain fatty acids (SCFAs), main bioactive microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component axis In present review, roles major (acetate, propionate butyrate) pathophysiology depression summarised with respect chronic cerebral hypoperfusion, neuroinflammation, host epigenome neuroendocrine alterations. Concluding remarks biological mechanisms related will hopefully address clinical value microbiota-related treatments for

Language: Английский

Citations

36
Artificial intelligence for diabetes: Enhancing prevention, diagnosis, and effective management DOI Creative Commons
Mohamed Khalifa,

Mona Albadawy

Computer Methods and Programs in Biomedicine Update, Journal Year: 2024, Volume and Issue: 5, P. 100141 - 100141

Published: Jan. 1, 2024

Diabetes, a major cause of premature mortality, affects millions globally, with its prevalence increasing due to lifestyle factors and aging populations. This systematic review explores the role Artificial Intelligence (AI) in enhancing prevention, diagnosis, management diabetes, highlighting potential for personalised proactive healthcare. A structured four-step method was used, including extensive literature searches, specific inclusion exclusion criteria, data extraction from selected studies focusing on AI's thorough analysis identify domains functions where AI contributes significantly. Through examining 43 experimental studies, has been identified as transformative force across eight key diabetes care: 1) Diabetes Management Treatment, 2) Diagnostic Imaging Technologies, 3) Health Monitoring Systems, 4) Developing Predictive Models, 5) Public Interventions, 6) Lifestyle Dietary Management, 7) Enhancing Clinical Decision-Making, 8) Patient Engagement Self-Management. Each domain showcases revolutionise care, personalising treatment plans improving diagnostic accuracy patient engagement predictive integration into care offers personalised, efficient, solutions. It enhances accuracy, empowers patients, provides better understanding management. However, successful implementation requires continued research, security, interdisciplinary collaboration, focus patient-centred Education healthcare professionals regulatory frameworks are also crucial address challenges like algorithmic bias ethics. promises improved health outcomes quality life through Future efforts should investment, ensuring fostering prioritising Regular monitoring evaluation essential adjust strategies understand long-term impacts, ethical effective

Language: Английский

Citations

21
Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression DOI Open Access
Nidesha Randeni, Baojun Xu

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 614 - 614

Published: Jan. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Language: Английский

Citations

4
Impact of adherence to the Mediterranean diet on stroke risk DOI Creative Commons
Zoltán Ungvári, Mónika Fekete, Péter Varga

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Language: Английский

Citations

2
The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease DOI Creative Commons
Samantha L. Dawson, Emma Todd, Alister C. Ward

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 329 - 329

Published: Jan. 31, 2025

Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment

Language: Английский

Citations

2