Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease

Revue Neurologique, Journal Year: 2019, Volume and Issue: 175(10), P. 724 - 741

Published: Sept. 11, 2019

Language: Английский

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An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer

European Journal of Nutrition, Journal Year: 2020, Volume and Issue: 60(3), P. 1561 - 1586

Published: Aug. 8, 2020

Abstract Purpose The aim of current systematic review was to update the body evidence on associations between adherence Mediterranean diet (MedDiet) and risk cancer mortality, site-specific in general population; all-cause, mortality as well reoccurrence among survivors. Methods A literature search for randomized controlled trials (RCTs), case–control cohort studies published up April 2020 performed using PubMed Scopus. Study-specific estimates highest versus lowest MedDiet category were pooled random-effects meta-analyses. Certainty from RCTs evaluated NutriGrade scoring system. Results updated revealed 44 not identified previous review. Altogether, 117 including 3,202,496 participants enclosed meta-analysis. inversely associated with (RR : 0.87, 95% CI 0.82, 0.92; N = 18 studies), all-cause survivors 0.75, 0.66, 0.86; 8), breast observational 0.94, 0.90, 0.97; 23), colorectal 0.83, 0.76, 0.90; 17), head neck 0.56, 0.44, 0.72; 9), respiratory 0.84, 0.94; 5), gastric 0.70, 0.61, 0.80; 7), bladder 0.98; 4), liver 0.64, 0.54, 0.75; 4). Adhering did modify blood, esophageal, pancreatic prostate risk. Conclusion In conclusion, our results suggest that related lower population, colorectal, neck, respiratory, gastric, risks. Moderate certainty an inverse association cancer, but most comparisons rated low or very evidence.

Language: Английский

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Precision medicine in the era of artificial intelligence: implications in chronic disease management

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Dec. 1, 2020

Abstract Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to and leading diminished life expectancy. A dysregulated induces secretion molecules which in turn trigger inflammatory pathway. Inflammation natural reaction immune system variety stimuli, such as pathogens, damaged cells, harmful substances. Metabolically triggered inflammation, also called metaflammation or low-grade chronic consequence synergic interaction between host exposome—a combination environmental drivers, including diet, lifestyle, pollutants other factors throughout span an individual. Various levels inflammation are associated with lifestyle-related diseases diabetes, obesity, metabolic fatty liver disease (MAFLD), cancers, cardiovascular disorders (CVDs), autoimmune diseases, lung diseases. Chronic growing concern worldwide, placing heavy on individuals, families, governments, health-care systems. New strategies needed empower communities worldwide prevent treat these Precision medicine provides model for next generation lifestyle modification. This will capitalize dynamic individual’s biology, behavior, environment. The aim precision design improve diagnosis, therapeutics prognostication through use large complex datasets that incorporate individual gene, function, variations. implementation high-performance computing (HPC) artificial intelligence (AI) can predict risks greater accuracy based available multidimensional clinical biological datasets. AI-powered clinicians opportunity specifically tailor early interventions each In this article, we discuss strengths limitations existing evolving recent, data-driven technologies, AI, preventing, treating reversing

Language: Английский

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KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease

Clinical and Molecular Hepatology, Journal Year: 2021, Volume and Issue: 27(3), P. 363 - 401

Published: June 22, 2021

Evidence collectionThe committee systematically collected and reviewed the international domestic literature published in PubMed, MEDLINE, KoreaMed, other databases.The was limited to research papers English Korean languages.The keywords used were 'nonalcoholic fatty liver disease,' liver,' steatohepatitis,' 'fatty 'hepatic steatosis,' 'steatohepatitis.'In addition, related specific clinical questions included. Levels of evidence grades recommendationsThe gathered for data collection analyzed a systematic review, quality classified based on modified Grading Recommendations, Assessment, Development Evaluation (GRADE) system (Table 1).According types studies, randomized, controlled studies approached from high level evidence, while observational low evidence.Subsequently, basis sets corresponding stud-

Language: Английский

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Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 742 - 742

Published: Aug. 13, 2020

Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some these could have an antiviral action or be important modulating immune system defending cells from oxidative stress associated infection. This short review draws attention components citrus fruits, especially orange (Citrus sinensis), well known for its vitamin flavonoid content. flavonoids, hesperidin recently attracted researchers, because it binds key proteins Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different showed that low binding energy, both “spike” protein, main protease transforms early virus (pp1a ppa1b) into complex responsible viral replication. The energy is lower than lopinavir, ritonavir, indinavir, suggesting perform effective action. Furthermore, ascorbic acid counteract cell damaging effects oxygen free radicals triggered infection inflammation. There discussion about preventive efficacy C, at dose achievable diet, but recent reviews suggest this substance can useful case strong burden caused disease. Computational methods laboratory studies support need undertake apposite preclinical, epidemiological, experimental benefits fruit prevention infectious diseases, including COVID-19.

Language: Английский

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Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 10, P. S404 - S421

Published: March 29, 2019

Language: Английский

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Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries

BMJ, Journal Year: 2020, Volume and Issue: unknown, P. m2194 - m2194

Published: July 8, 2020

Abstract Objective To investigate the association of plasma vitamin C and carotenoids, as indicators fruit vegetable intake, with risk type 2 diabetes. Design Prospective case-cohort study. Setting Populations from eight European countries. Participants 9754 participants incident diabetes, a subcohort 13 662 individuals Investigation into Cancer Nutrition (EPIC) cohort 340 234 participants: EPIC-InterAct Main outcome measure Incident Results In multivariable adjusted model, higher was associated lower developing diabetes (hazard ratio per standard deviation 0.82, 95% confidence interval 0.76 to 0.89). A similar inverse shown for total carotenoids 0.75, 0.68 0.82). composite biomarker score (split five equal groups), comprising individual inversely hazard ratios 0.77, 0.66, 0.59, 0.50 groups 2-5 compared group 1 (the lowest group). Self-reported median intake 274 g/day, 396 508 g/day in categories defined by 1, 3, 5 score, respectively. One difference equivalent 66 (95% 61 71) 0.75 (0.67 0.83). This would be an absolute reduction 0.95 1000 person years follow up if achieved across entire population characteristics countries included this analysis. Conclusions These findings indicate between C, their different biomarkers are objective consumption, suggest that diets rich even modestly consumption could help prevent development

Language: Английский

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Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

Molecular Carcinogenesis, Journal Year: 2020, Volume and Issue: 59(4), P. 365 - 389

Published: Feb. 3, 2020

Abstract α‐Tocopherol (α‐T) is the major form of vitamin E (VE) in animals and has highest activity carrying out essential antioxidant functions VE. Because involvement oxidative stress carcinogenesis, cancer prevention α‐T been studied extensively. Lower VE intake or nutritional status shown to be associated with increased risk, supplementation populations insufficiency beneficial effects lowering risk some intervention studies. However, several large studies conducted North America have not demonstrated a effect. More recent centered on γ‐ δ‐forms tocopherols tocotrienols (T3). In comparison α‐T, these forms much lower systemic bioavailability but stronger cancer‐preventive activities many animal models cell lines. γ‐T3 δ‐T3 generally even higher than γ‐T δ‐T. this article, we review results from human laboratory different tocotrienols, at pharmacological levels. We aim elucidate possible mechanisms preventive actions discuss application available information for by forms.

Language: Английский

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Associations of Serum Carotenoids With Risk of Cardiovascular Mortality Among Individuals With Type 2 Diabetes: Results From NHANES

Diabetes Care, Journal Year: 2022, Volume and Issue: 45(6), P. 1453 - 1461

Published: May 3, 2022

OBJECTIVE Although carotenoids have been suggested to exhibit antioxidant properties, some experimental studies reported that β-carotene may show pro-oxidant effects under certain conditions. Current evidence regarding the cardiovascular of among patients with type 2 diabetes (T2D) is scarce. This study aimed prospectively examine associations individual serum carotenoid concentrations mortality adults T2D. RESEARCH DESIGN AND METHODS analysis included 3,107 individuals T2D from Third National Health and Nutrition Examination Survey (NHANES III) NHANES 2001–2006. Cardiovascular was ascertained by linkage Death Index records through 31 December 2015. Cox proportional hazards regression models were used estimate hazard ratios (HRs) 95% CIs. RESULTS During an average 14 years follow-up, 441 deaths occurred. After multivariate adjustment including lifestyles, dietary factors, glucose control, other major carotenoids, higher significantly associated elevated risk in a dose-response manner. When extreme quartiles compared, multivariable-adjusted HR 2.47 (95% CI 1.62, 3.76) for (Ptrend = 0.002); per one-unit increment natural log-transformed 46% (P 0.001). Other (α-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin) not mortality. Consistent results observed when stratifying age, sex, race, BMI, smoking status, duration, glycated hemoglobin A1c levels. CONCLUSIONS Higher β-carotene, but increased Our findings, if replicated, underscore need optimal

Language: Английский

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Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022

Journal of Atherosclerosis and Thrombosis, Journal Year: 2023, Volume and Issue: 31(6), P. 641 - 853

Published: Dec. 18, 2023

Language: Английский

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