Poultry Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104956 - 104956
Published: March 1, 2025
Infectious
bronchitis
virus
(IBV)
is
a
major
pathogen
that
causes
significant
economic
losses
in
the
global
poultry
industry.
Current
vaccination
strategies
provide
only
partial
protection,
highlighting
need
for
more
effective
prevention
and
treatment
methods.
This
study
aimed
to
develop
novel
compound
throat
anti-viral
(CTA)
from
natural
plants
using
data
Traditional
Chinese
Medicine
Inheritance
System
identification
through
liquid
chromatography-mass
spectrometry.
CTA
demonstrated
substantial
anti-IBV
effects
both
vitro
vivo
studies.
In
vitro,
significantly
inhibited
IBV
multiplication
alleviated
pathological
lesions
chicken
embryonic
kidney
cells,
tracheal
rings,
embryos.
vivo,
seven-day
with
obtained
much
milder
clinical
signs,
enhanced
growth
performance,
better
immune
organ
indices
infected
chickens.
Additionally,
reduced
levels
trachea
lungs
increased
specific
antibody
titers.
also
maintained
body
homeostasis,
exhibiting
strong
antioxidant
anti-inflammatory
properties
mitigated
respiratory
tract
damage.
Metabolomics
network
pharmacology
analyses,
revealed
CTA's
antiviral
are
mediated
FoxO
signaling
pathway.
successfully
developed
an
prescription
database
based
on
validated
efficacy
of
comprehensive
experiments.
The
findings
elucidated
mechanisms
action,
particularly
pathway,
highlighted
its
potential
application
as
Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 12, 2025
Abstract
Network
pharmacology
plays
a
pivotal
role
in
systems
biology,
bridging
the
gap
between
traditional
Chinese
medicine
(TCM)
theory
and
contemporary
pharmacological
research.
enables
researchers
to
construct
multilayered
networks
that
systematically
elucidate
TCM’s
multi-component,
multi-target
mechanisms
of
action.
This
review
summarizes
key
databases
commonly
used
network
pharmacology,
including
those
focused
on
herbs,
components,
diseases,
dedicated
platforms
for
analysis.
Additionally,
we
explore
growing
use
TCM,
citing
literature
from
Web
Science,
PubMed,
CNKI
over
past
two
decades
with
keywords
like
“network
pharmacology”,
“TCM
“herb
pharmacology”.
The
application
TCM
is
widespread,
covering
areas
such
as
identifying
material
basis
efficacy,
unraveling
action,
evaluating
toxicity,
safety,
novel
drug
development.
However,
challenges
remain,
lack
standardized
data
collection
across
insufficient
consideration
processed
herbs
Questions
also
persist
regarding
reliability
study
outcomes.
aims
offer
valuable
insights
reference
points
guide
future
research
precision
pharmacology.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(5)
Published: Sept. 1, 2024
Abstract
Network
pharmacology
is
an
emerging
interdisciplinary
research
method.
The
application
of
network
to
reveal
the
nutritional
effects
and
mechanisms
active
ingredients
in
food
great
significance
promoting
development
functional
food,
facilitating
personalized
nutrition,
exploring
health
effects.
This
article
systematically
reviews
field
science
using
a
literature
review
progress
discussed,
factors
on
basis
are
explored.
Additionally,
limitations
challenges
future
directions
prospects
proposed.
serves
as
important
tool
action
benefits
food.
It
helps
conduct
in‐depth
biological
activities
individual
ingredients,
composite
foods,
compounds
assessment
potential
components.
Moreover,
it
can
help
control
enhance
their
functionality
through
relevant
information
during
production
processing
samples
guarantee
safety.
further
analyzed
summarized.
Combining
machine
learning,
artificial
intelligence,
clinical
experiments,
vitro
validation,
achievement
transformation
factor
driven
by
for
research.
Molecular Medicine Reports,
Journal Year:
2025,
Volume and Issue:
31(3)
Published: Jan. 24, 2025
The
present
study
aimed
to
investigate
the
cardioprotective
effects
of
acteoside
(AC)
on
myocardial
ischemia‑reperfusion
injury
(MIRI).
To
meet
this
aim,
a
network
pharmacological
analysis
was
conducted
search
for
key
genes
and
signaling
pathways
associated
with
AC
MIRI.
infarct
size
rat
heart
evaluated
using
2,3,5‑triphenyltetrazolium
chloride
staining,
serum
levels
creatine
kinase
MB
isoenzyme,
cardiac
troponin
I,
malondialdehyde
superoxide
dismutase
were
subsequently
detected
in
an
vivo
experiment.
inhibitory
effect
oxidative
stress
further
confirmed
by
assessing
intracellular
accumulation
reactive
oxygen
species
(ROS).
Hematoxylin
eosin
staining
carried
out
observe
histopathological
damage.
anti‑apoptotic
determined
terminal
deoxynucleotidyl‑transferase‑mediated
dUTP
nick
end
labeling
assay
Hoechst
33342
expression
apoptosis‑associated
proteins
tissue
assessed
immunohistochemical
analysis.
In
addition,
cell
viability
Cell
Counting
Kit‑8
assay,
target
MIRI
western
blot
results
suggested
that
pretreatment
could
mitigate
MIRI‑induced
damage,
apoptosis.
elevated
Bcl‑2
levels,
reduced
caspase‑3
Bax
tissue.
vitro,
both
led
increased
rate
survival
alleviated
stress,
as
demonstrated
decreased
level
ROS
accumulation.
Moreover,
guided
analysis,
heat‑shock
protein
90AA1
(HSP90AA1)
phosphoinositide
3‑kinase
(PI3K)/serine‑threonine
(Akt)
pathway
emerged
targets
action
against
Furthermore,
showed
significant
increase
activity
PI3K/Akt
pathway,
addition
glycogen
synthase
kinase‑3β
HSP90AA1.
Taken
together,
findings
revealed
may
exert
through
suppressing
apoptosis
regulating
proteins.
Annals of Medicine,
Journal Year:
2023,
Volume and Issue:
55(2)
Published: Dec. 12, 2023
Purpose
The
aim
of
this
study
is
to
determine
the
effectiveness
and
reliability
adding
traditional
Chinese
medicine
(TCM)
in
clinical
intervention
explore
mechanisms
action
for
chronic
atrophic
gastritis
(CAG)
through
meta-
network
pharmacology
analysis
(NPAs).
