Clinical Immunology Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Dermatologic Clinics, Journal Year: 2025, Volume and Issue: 43(2), P. 179 - 191
Published: Jan. 8, 2025
Language: Английский
Citations
3
British Journal of Dermatology, Journal Year: 2025, Volume and Issue: 192(Supplement_1), P. i3 - i14
Published: Feb. 1, 2025
Hidradenitis suppurativa (HS) is a complex inflammatory disease, with rapid advances being made in our understanding of the immunological pathogenesis condition. New insights into genomic landscape HS have identified number genes that contribute to development polygenic manner, contributing dysregulation and alterations epidermal stem cell fate follicular unit. These variations can explain unique aspects disease such as presence epithelialized tunnels abnormalities wound healing. From genetic translational studies, it likely these predispose an innate immune be triggered through sex hormone-responsive transcription factors hormonal changes puberty, pregnancy menstrual cycle. The role hormones also has direct effects upon maturation cells monocytes, which potential differential patient response treatments interleukin-23 antagonism. adipose tissue active organ plays seen disease. Fibrotic immunologically fibroblasts play significant perpetuation inflammation adaptive dysfunction cutaneous gut microbiomes roles activation immunity, although conflicting data exist their central or peripheral pathogenesis. Overall, moving toward more nuanced, paradigm heterogeneity presentation characteristics are closer identification therapeutic biomarkers guide modalities management this burdensome
Language: Английский
Citations
2
Journal of the American Academy of Dermatology, Journal Year: 2024, Volume and Issue: 91(1), P. 170 - 172
Published: March 28, 2024
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10152 - 10152
Published: Sept. 21, 2024
Many skin diseases begin with inflammatory changes on a molecular level. To develop more thorough understanding of pathology and to identify new targets for therapeutic advancements, mechanisms inflammation in the context disease should be studied. Current research efforts better understand have focused examining role processes at several stages response such as dysregulation innate immunity sensors, disruption both transcriptional post-transcriptional regulation, crosstalk between immune neuronal (neuro-immune crosstalk). This review seeks summarize recent developments our highlight opportunities advancements. With focus publications within past 5 years (2019–2024), databases PubMed EBSCOhost were used search peer-reviewed papers regarding disease. Several themes interest determined through extensive included based their relative representation current potential. psoriasis, atopic dermatitis, hidradenitis suppurativa, scleroderma described paper demonstrate widespread influence
Language: Английский
Citations
5
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(48)
Published: Nov. 19, 2024
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with poorly understood immunopathogenesis. Here, we report that HS lesional characterized by the expansion of innate lymphocytes and T cells expressing CD2, an essential activation receptor adhesion molecule. Lymphocytes elevated CD2 predominated unique spatial distribution throughout epidermis hypodermis in lesion. + were mainly NK cell marker, CD56, CD4 cells. Importantly, these interacted CD58 (LFA3) epidermal keratinocytes fibroblasts hypodermis. Granzyme A bright NKT (CD2 CD3 CD56 ) clustered α-SMA juxtaposed to epithelialized tunnels fibrotic regions Whereas dim perforin , granzymes B enriched adjacent hyperplastic follicular showing presence apoptotic The cytokines IL-12, IL-15, IL-18, which enhance maturation function significantly HS. Ex vivo explant cultures treated CD2:CD58 interaction-blocking anti-CD2 monoclonal antibody attenuated secretion cytokines/chemokines suppressed gene signature. Additionally, blockade altered miRNAs involved NK/NKT differentiation and/or function. In summary, show cellular network heterogenous populations drives inflammation critical pathobiology HS, including tunnel formation fibrosis. Finally, viable immunotherapeutic approach for effective management
Language: Английский
Citations
4
Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 241 - 241
Published: Feb. 10, 2025
The skin provides a life-sustaining interface between the body and external environment. A dynamic communication among immune non-immune cells in is essential to ensure homeostasis. Dysregulated cellular can lead manifestation of inflammatory conditions. In this review, we will focus on following two key frontiers skin: innate sensors cell death, as well their crosstalk context homeostasis inflammation. This review highlight recent advancements mechanisms how these pathways integrate signals orchestrate immunity, focusing diseases infections mice humans.
Language: Английский
Citations
0
Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2025, Volume and Issue: 5(2), P. 2S14 - 2S20
Published: Feb. 1, 2025
Citations
0
Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2025, Volume and Issue: 5(2), P. 2S7 - 2S13
Published: Feb. 1, 2025
Citations
0
Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Hidradenitis suppurativa (HS) is a chronic skin condition with significant impact on patient quality of life, highlighting the need for innovative therapeutic approaches. HS characterized by its chronicity; it presents in form painful nodules, abscesses, and sinus tracts or fistulas, typically localized intertriginous areas, emerging early adulthood predominantly female population. In this review, authors discuss preclinical discovery development secukinumab HS, target identification, validation, compound selection. Methodologies such as high-content screening, chemoinformatics, animal models that validate IL-17 pathway's role are explored. The transition from to clinical development, including pharmacokinetics (PK), pharmacodynamics (PD), ADME-Tox studies, elaborated. literature search was conducted using PubMed, Web Science, Scopus, UpToDate, Cochrane Library, Embase, Google Scholar, covering relevant studies published up December 2024. integration into treatment highlights critical targeting IL-17A pathway. Although efficacious safe trials, understanding secukinumab's long-term effects optimal placement remains challenging. Future research should prioritize tailored strategies align individual disease phenotypes immune profiles enhance outcomes management.
Language: Английский
Citations
0
Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103818 - 103818
Published: April 1, 2025
Language: Английский
Citations
0