Blood-Based Protein Biomarkers in the Chronic Phase of Traumatic Brain Injury: A Systematic Review DOI
Amelia J. Hicks, Holly Carrington,

Lisa Bura

et al.

Journal of Neurotrauma, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

There has been limited exploration of blood-based biomarkers in the chronic period following traumatic brain injury (TBI). Our objective was to conduct a systematic review studies examining protein with at least one sample collected 12 months post-TBI adults (≥16 years). Database searches were conducted Embase, MEDLINE, and Science Citation Index-Expanded on July 24, 2023. Risk bias assessed using modified Joanna Briggs Institute critical appraisal tools. Only 30 12,523 articles met inclusion criteria, samples drawn from 48 years. Higher quality evidence (low risk bias; large samples) identified promising inflammatory post-injury both moderate-severe TBI (GFAP) mild (eotaxin-1, IFN-y, IL-8, IL-9, IL-17A, MCP-1, MIP-1β, FGF-basic, TNF-α). Studies low but smaller also suggest NSE, MME, CRP may be informative, alongside variants for α-syn (10H, D5), amyloid-β (A4, C6T), TDP-43 (AD-TDP 1;2;3;9;11), tau (D11C). Findings NfL inconclusive. Longitudinal data mostly available acute followed until post-injury, evaluation changes beyond months. Associations some cognitive, sleep, functional outcomes reported. The overall strength this by small sizes. Replication is required within prospective longitudinal that move post-injury. Novel efforts should guided neurodegenerative-disease markers use panels model polypathology.

Language: Английский

Traumatic brain injury: progress and challenges in prevention, clinical care, and research DOI Creative Commons
Andrew I.R. Maas, David Menon,

Geoffrey T. Manley

et al.

The Lancet Neurology, Journal Year: 2022, Volume and Issue: 21(11), P. 1004 - 1060

Published: Sept. 29, 2022

Language: Английский

Citations

648
Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury DOI Creative Commons

Yayi Yang,

Dengfeng Lu, Menghan Wang

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(2)

Published: Feb. 20, 2024

Abstract Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease still unsatisfactory. Therefore, it necessary to investigate pathophysiological mechanisms TBI in depth improve treatment options. In recent decades, abundant evidence has highlighted significance endoplasmic reticulum stress (ERS) advancing central nervous system (CNS) disorders, including TBI. ERS following leads accumulation unfolded proteins, initiating protein response (UPR). Protein kinase RNA-like ER (PERK), inositol-requiring 1 (IRE1), activating transcription factor 6 (ATF6) are three major pathways UPR initiation that determine whether cell survives or dies. This review focuses on dual effects discusses underlying mechanisms. It suggested may crosstalk series molecular cascade responses, such as mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, death, thus involved progression secondary after Hence, promising candidate for

Language: Английский

Citations

30
Blood biomarkers for traumatic brain injury: A narrative review of current evidence DOI Creative Commons
Iftakher Hossain, Niklas Marklund, Endre Czeiter

et al.

Brain and Spine, Journal Year: 2023, Volume and Issue: 4, P. 102735 - 102735

Published: Dec. 14, 2023

A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, detect and treat secondary insults, predict outcomes, monitor treatment effects quality of care. What evidence is available for clinical applications BBBMs in TBI how advance this field? This narrative review discusses the potential core TBI. literature search PubMed, Scopus, ISI Web Knowledge focused on articles English words "traumatic injury" together "blood biomarkers", "diagnostics", "outcome prediction", "extracranial "assay method" alone-, or combination. Glial fibrillary acidic protein (GFAP) combined Ubiquitin C-terminal hydrolase-L1(UCH-L1) has received FDA clearance aid computed tomography (CT)-detection lesions mild (m) Application S100B led reduction head CT scans. GFAP may also magnetic resonance imaging (MRI) abnormalities CT-negative cases Further, UCH-L1, S100B, Neurofilament light (NF-L), total tau showed value predicting mortality unfavourable outcome. Nevertheless, biomarkers have less role outcome prediction mTBI. serve as a tool multimodality monitoring neurointensive care unit. Largescale systematic studies are required explore kinetics their use multiple groups. Assay development/cross validation should generalizability those results which implicated GFAP, NF-L most promising diagnostics

Language: Английский

Citations

27
Opportunities and Challenges of Microneedle Electrochemical Sensors for Interstitial Fluid Detection DOI
Yanming Dong,

Siying Mao,

Shiwei Chen

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117891 - 117891

Published: July 31, 2024

Language: Английский

Citations

14
Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes—an analysis of CENTER-TBI data DOI Creative Commons
Chiara Robba, Francesca Graziano, Edoardo Picetti

et al.

Intensive Care Medicine, Journal Year: 2024, Volume and Issue: 50(3), P. 371 - 384

Published: Feb. 20, 2024

We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light (NfL), glial fibrillary acidic (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), Tau], critical needs, [Glasgow Outcome Scale Extended (GOSE)]. Among 1695 patients, 24.5% had SIs: 16.1% hypoxemia, 15.2% 6.8% both. Biomarkers differed by SI category, higher S100B, Tau, UCH-L1, NSE NfL values hypotension or both SIs. The ratio neural (quantified as UCH-L1/GFAP Tau/GFAP ratios) was than those no hypoxia alone. At 6 months, 380 died (22%), 759 (45%) GOSE ≤ 4. Patients who experienced at least one mortality did not (31.8% vs. 19%, p < 0.001). Though less frequent previously described, are associated release neuronal increased ICU therapies aimed reducing intracranial hypertension. Hypotension combined significantly adverse outcomes. Current criteria may lead more negative hypoxemia suggesting a need revisit pressure targets prehospital settings.

Language: Английский

Citations

11
Deep learning based tractography with TractSeg in patients with hemispherotomy: Evaluation and refinement DOI Creative Commons

Johannes Gruen,

Tobias Bauer, Theodor Rüber

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103738 - 103738

Published: Jan. 1, 2025

Language: Английский

Citations

1
Trajectories of blood-based protein biomarkers in chronic traumatic brain injury DOI Open Access
Amelia J. Hicks,

Jay Plourde,

Enna Selmanovic

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Blood-based protein biomarkers may provide important insights into the long-term neuropathology of traumatic brain injury (TBI). This is urgently required to identify mechanistic processes underlying post-traumatic neurodegeneration (PTND); a progressive post-recovery clinical decline experienced by portion TBI survivors. The aim this study was examine change over time in levels chronic cohort. We selected six markers (Aβ 42 /Aβ 40 , GFAP, NfL, BD-tau, p-tau231, and p-tau181) with known importance acute and/or other neurodegenerative conditions. used longitudinal design two points approximately 3.5 years apart on average (SD 1.34). Proteins were measured plasma using ultrasensitive Single molecule array technology for 63 participants mild severe (sustained ≥ 1 year ago; M 28 years; SD 16.3 since their first blow head) from Late Effects (48% female; current age 52 13.4). Multivariate linear mixed effect models adjustments multiple comparisons performed trajectories proteins squared as covariates. A series sensitivity analyses conducted account outliers explore effects key covariates: sex, APOE ε4 carrier status, medical comorbidities, at head, severity. Over an years, there significant reductions Aβ (β = −0.004, SE 0.001, t −3.75, q .001) increases GFAP 12.96, 4.41, 2.94, .01). There no changes NFL, or p-tau181. Both have been associated amyloidosis, suggesting role mis-metabolism aggregation neuropathological consequences TBI. These findings are hypothesis generating future studies exploring diverse biological mechanisms PTND.

Language: Английский

Citations

1
The 2022 Lady Estelle Wolfson lectureship on neurofilaments DOI Creative Commons
Axel Petzold

Journal of Neurochemistry, Journal Year: 2022, Volume and Issue: 163(3), P. 179 - 219

Published: Aug. 11, 2022

Neurofilament proteins (Nf) have been validated and established as a reliable body fluid biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, light (NfL), two splicing variants of medium (NfM), heavy (NfH),

Language: Английский

Citations

31
Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study DOI
Cecilia Åkerlund, Anders Vedel Holst, Shubhayu Bhattacharyay

et al.

The Lancet Neurology, Journal Year: 2023, Volume and Issue: 23(1), P. 71 - 80

Published: Nov. 14, 2023

Language: Английский

Citations

21
Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI DOI Creative Commons
Pashtun Shahim, Dzung L. Pham,

André J. van der Merwe

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(7), P. 4663 - 4676

Published: May 28, 2024

We examined spatial patterns of brain atrophy after mild, moderate, and severe traumatic injury (TBI), the relationship between progression with initial axonal (TAI), cognitive outcome, serum biomarkers injury.

Language: Английский

Citations

7