Blood-Based Protein Biomarkers in the Chronic Phase of Traumatic Brain Injury: A Systematic Review DOI
Amelia J. Hicks, Holly Carrington,

Lisa Bura

et al.

Journal of Neurotrauma, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

There has been limited exploration of blood-based biomarkers in the chronic period following traumatic brain injury (TBI). Our objective was to conduct a systematic review studies examining protein with at least one sample collected 12 months post-TBI adults (≥16 years). Database searches were conducted Embase, MEDLINE, and Science Citation Index-Expanded on July 24, 2023. Risk bias assessed using modified Joanna Briggs Institute critical appraisal tools. Only 30 12,523 articles met inclusion criteria, samples drawn from 48 years. Higher quality evidence (low risk bias; large samples) identified promising inflammatory post-injury both moderate-severe TBI (GFAP) mild (eotaxin-1, IFN-y, IL-8, IL-9, IL-17A, MCP-1, MIP-1β, FGF-basic, TNF-α). Studies low but smaller also suggest NSE, MME, CRP may be informative, alongside variants for α-syn (10H, D5), amyloid-β (A4, C6T), TDP-43 (AD-TDP 1;2;3;9;11), tau (D11C). Findings NfL inconclusive. Longitudinal data mostly available acute followed until post-injury, evaluation changes beyond months. Associations some cognitive, sleep, functional outcomes reported. The overall strength this by small sizes. Replication is required within prospective longitudinal that move post-injury. Novel efforts should guided neurodegenerative-disease markers use panels model polypathology.

Language: Английский

Microneedle-Integrated Sensors for Extraction of Skin Interstitial Fluid and Metabolic Analysis DOI Open Access
Jie Yang, Ruiyu Luo, Lei Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9882 - 9882

Published: June 8, 2023

Skin interstitial fluid (ISF) has emerged as a fungible biofluid sample for blood serum and plasma disease diagnosis therapy. The sampling of skin ISF is highly desirable considering its easy accessibility, no damage to vessels, reduced risk infection. Particularly, can be sampled using microneedle (MN)-based platforms in the tissues, which exhibit multiple advantages including minimal invasion less pain, ease carrying, capacity continuous monitoring, etc. In this review, we focus on current development microneedle-integrated transdermal sensors collecting detecting specific biomarkers. Firstly, discussed classified microneedles according their structural design, solid MNs, hollow porous coated MNs. Subsequently, elaborate construction MN-integrated metabolic analysis with highlights electrochemical, fluorescent, chemical chromogenic, immunodiagnostic, molecular diagnostic sensors. Finally, discuss challenges future direction developing MN-based extraction sensing applications.

Language: Английский

Citations

16
Mastering the brain in critical conditions: an update DOI Creative Commons
Chiara Robba, Elisa R. Zanier,

Carmen Lopez Soto

et al.

Intensive Care Medicine Experimental, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 5, 2024

Abstract Acute brain injuries, such as traumatic injury and ischemic hemorragic stroke, are a leading cause of death disability worldwide. While characterized by clearly distict primary events—vascular damage in strokes biomechanical injuries—they share common secondary mechanisms influencing long-term outcomes. Growing evidence suggests that more personalized approach to optimize energy substrate delivery the injured prognosticate towards families could be beneficial. In this context, continuous invasive and/or non-invasive neuromonitoring, together with clinical evaluation neuroimaging support strategies cerebral blood flow metabolic delivery, well approaches neuroprognostication gaining interest. Recently, European Society Intensive Care Medicine organized 2-day course focused on practical case-based acute brain-injured patients different scenarios future perspectives advance management population. The aim manuscript is update clinicians dealing intensive care unit, describing current knowledge practice based insights presented during course.

Language: Английский

Citations

6
White matter damage and degeneration in traumatic brain injury DOI Creative Commons
Regina C. Armstrong, Genevieve M. Sullivan, Daniel P. Perl

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(9), P. 677 - 692

Published: Aug. 10, 2024

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with aging. TBI damages neurons long axons within white matter tracts are critical for communication between regions; this causes slowed information processing neuronal circuit dysfunction. This review focuses on after multifactorial processes underlie damage, potential recovery, progression degeneration. A multiscale perspective across clinical preclinical advances presented encourage interdisciplinary insights from whole-brain neuroimaging down cellular molecular responses axons, myelin, glial cells tissue.

Language: Английский

Citations

5
The role of astrocyte in neuroinflammation in traumatic brain injury DOI Creative Commons
Liang He, Ruqiang Zhang,

Maiqiao Yang

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1870(3), P. 166992 - 166992

Published: Dec. 19, 2023

Language: Английский

Citations

13
The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review DOI Creative Commons
Liivia-Mari Lember, Michail Ntikas, Stefania Mondello

et al.

Sports Medicine - Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 25, 2024

Amidst growing concern about the safety of sport-related repetitive subconcussive head impacts (RSHI), biofluid markers may provide sensitive, informative, and practical assessment effects RSHI exposure. This scoping review aimed to systematically examine extent, nature, quality available evidence from studies investigating on markers, identify gaps formulate guidelines inform future research. PRISMA extension for Scoping Reviews were adhered to. The protocol was pre-registered through publication. MEDLINE, Scopus, SPORTDiscus, CINAHL, PsycINFO, Cochrane Library, OpenGrey, two clinical trial registries searched (until March 30, 2022) using descriptors impacts, biomarkers, contact sports. Included assessed risk bias quality. Seventy-nine research publications included in review. Forty-nine acute effects, 23 semi-acute 26 long-term most studied sports American football, boxing, soccer, investigated (in descending order): S100 calcium-binding protein beta (S100B), tau, neurofilament light (NfL), glial fibrillary acidic (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), phosphorylated tau (p-tau), ubiquitin C-terminal hydrolase L1 (UCH-L1), hormones. High or moderate found studies, marker-specific conclusions subject heterogeneous limited evidence. Although is weak, some markers-such as NfL-appeared show promise. More markedly, S100B be problematic when evaluating sport. Considering limitations base revealed by this first dedicated marker levels following exposure, field evidently still its infancy. As a result, any recommendation application premature. promise brain health large standardized better-controlled are needed determine markers' utility.

Language: Английский

Citations

4
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia DOI

Kumar Vaibhav,

Mayuri Gulhane,

Pankaj Ahluwalia

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(6), P. 5439 - 5457

Published: May 11, 2024

Language: Английский

Citations

4
Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities in a community‐dwelling cohort DOI Creative Commons
Marc D. Rudolph, Courtney L. Sutphen, Thomas C. Register

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(6), P. 4159 - 4173

Published: May 15, 2024

We evaluated associations between plasma and neuroimaging-derived biomarkers of Alzheimer's disease related dementias the impact health-related comorbidities.

Language: Английский

Citations

4
Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study DOI Creative Commons

Sophie Richter,

Stefan Winzeck,

Marta Correia

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 75, P. 102751 - 102751

Published: Aug. 8, 2024

BackgroundEven patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mild traumatic brain injury (mTBI). There is currently no good way predict recovery and triage who benefit from early follow-up targeted intervention. We aimed assess if existing prognostic models can be improved by serum biomarkers or diffusion tensor metrics (DTI) MRI, identify DTI.MethodsWe included 1025 aged >18 a Glasgow Coma Score >12 CT the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study which recruited between December 19,2014 17, 2017 (NCT02210221). Biomarkers (GFAP, NFL, S100B) were obtained at median of 8.8 h (Q1–Q3 4.2–16.7) DTI 13 days (3–19) injury. available 153 48 white matter tracts (ICBM-DTI-81 atlas). Incomplete three was defined as an extended Outcome Scale score <8. Existing fitted without biomarkers, DTI, internally validated using bootstrapping.Findings385 (38%) had incomplete recovery. Adding did not improve performance beyond best clinical model [optimism-corrected AUC 0.69 (95% CI 0.65–0.72) R2 17% (11–22)]. significantly enhanced all [best optimism-corrected 0.82 (0.79–0.85) 75% (39–100)]. The top left posterior thalamic radiation, superior cerebellar peduncle right uncinate fasciculus. Serum could have avoided 1 5 scans, GFAP <12 NFL 12–24 performing best.InterpretationDTI substantially functional outcome mTBI CT, help select MRI. If validated, allow enrichment trials interventions outcome.FundingEU Seventh Framework Programme, Hannelore Kohl Stiftung, One Mind, Integra LifeSciences, Sciences.

Language: Английский

Citations

4
Fluid biomarkers of chronic traumatic brain injury DOI

Susanna Friberg,

Caroline Lindblad, Frederick A. Zeiler

et al.

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

4
Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs DOI Creative Commons

Marissa Alvarez,

Erick Trent,

Bruno de Souza Gonçalves

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Oct. 4, 2022

COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with broad spectrum of clinical manifestations. The evolving scientific evidence demonstrates that the frequency cognitive impairment after high it crucial to explore more research implement proper diagnostic treatment strategies. Several central nervous system complications have been reported comorbidities COVID-19. changes in function associated neurodegenerative diseases develop slowly over time are only diagnosed at an already advanced stage molecular pathology. Hence, understanding common links between will broaden our knowledge help strategizing prognostic therapeutic approaches. present review focuses on diverse highlight importance major circulating biomarkers microRNAs (miRNAs) progression severity. literature analysis showed proteins function, such Glial fibrillary acidic protein, neurofilament light chain, p-tau 181, Ubiquitin C-terminal hydrolase L1, S100 calcium-binding protein B, Neuron-specific enolase various inflammatory cytokines, were significantly altered patients. Furthermore, among miRNAs pivotal roles diseases, miR-146a, miR-155, Let-7b, miR-31, miR-16 miR-21 shown significant dysregulation Thus consolidates important findings from numerous studies unravel underlying mechanism neurological sequelae possible association circulatory biomarkers, which may serve predictors targets future research.

Language: Английский

Citations

19