Fibrosis‐on‐Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease DOI Creative Commons
Emma M. Streutker, Utku Devamoglu, Madelon C Vonk

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(21)

Published: March 27, 2024

Fibrosis, which is primarily marked by excessive extracellular matrix (ECM) deposition, a pathophysiological process associated with many disorders, ultimately leads to organ dysfunction and poor patient outcomes. Despite the high prevalence of fibrosis, currently there exist few therapeutic options, importantly, paucity in vitro models accurately study fibrosis. This review discusses multifaceted nature fibrosis from viewpoint developing organ-on-chip (OoC) disease models, focusing on five key features: ECM component, inflammation, mechanical cues, hypoxia, vascularization. The potential OoC technology explored for better modeling these features context studying fibrotic diseases interplay between various emphasized. paper reviews how organ-specific are modeled platforms, elements included existing avenues novel research directions highlighted. Finally, this concludes perspective address current gap respect inclusion multiple yield more sophisticated relevant an format.

Language: Английский

Astragaloside IV as a promising therapeutic agent for liver diseases: current landscape and future perspectives DOI Creative Commons
Chunyan Chen,

Xuexian Bu,

Liping Deng

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Astragaloside IV (C 41 H 68 O 14 , AS-IV) is a naturally occurring saponin isolated from the root of Astragalus membranaceus widely used traditional Chinese botanical drug in medicine. In recent years, AS-IV has attracted considerable attention for its hepatoprotective properties, which are attributed to low toxicity as well anti-inflammatory, antioxidant and antitumour effects. Numerous preclinical studies have demonstrated potential prevention treatment various liver diseases, including multifactorial injury, metabolic-associated fatty disease, fibrosis cancer. Given promising growing interest research, this review provides comprehensive summary current state research on effects AS-IV, based literature available databases such CNKI, PubMed, ScienceDirect, Google Scholar Web Science. The mechanisms multifaceted, encompassing inhibition inflammatory responses, reduction oxidative stress, improvement insulin leptin resistance, modulation gut microbiota, suppression hepatocellular carcinoma cell proliferation induction tumour apoptosis. Notably, key molecular pathways involved these include Nrf2/HO-1, NF-κB, NLRP3/Caspase-1, JNK/c-Jun/AP-1, PPARα/FSP1 Akt/GSK-3β/β-catenin. Toxicity indicate that high level safety. addition, discusses sources, physicochemical challenges development clinical application providing valuable insights into agent pharmaceutical nutraceutical industries.

Language: Английский

Citations

0
Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: Insight into NLRP3 inflammasome and SPHK1/S1P/Hippo signaling modulation DOI

Menna S. Zeyada,

Salma M. Eraky, Mamdouh M. El‐Shishtawy

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122272 - 122272

Published: Nov. 18, 2023

Language: Английский

Citations

10
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis DOI
Azam Hosseinzadeh, Mohammad Hossein Pourhanifeh, Shiva Amiri

et al.

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 76(1), P. 25 - 50

Published: Nov. 23, 2023

Language: Английский

Citations

9
Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence DOI Open Access
Tong Hou, Jiyang Zhang,

Yindan Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2992 - 2992

Published: March 5, 2024

It is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and waves are lacking. Previous reports revealed heatstroke induced acute lung injury pulmonary dysfunction. This study aimed investigate whether exposure fibrosis explore underlying mechanisms. Male C57BL/6 mice were exposed an ambient 39.5 ± 0.5 °C until their core reached maximum or exhaustion state. Lung was observed in lungs heat-exposed mice, with extensive collagen deposition elevated expression molecules, including transforming growth factor-β1 (TGF-β1) Fibronectin (Fn1) (p < 0.05). Moreover, epithelial–mesenchymal transition (EMT) occurred response exposure, evidenced by E-cadherin, epithelial marker, which downregulated, whereas markers EMT, such as connective tissue factor (CTGF) zinc finger transcriptional repressor protein Slug, upregulated tissues Subsequently, cell senescence examination levels both senescence-associated β-galactosidase (SA-β-gal) staining cycle kinase inhibitor p21 significantly Mechanistically, cGAS–STING signaling pathway evoked DNA damage activated In summary, we reported a new finding contributed development early fibrosis-like changes through damage-activated followed cellular senescence.

Language: Английский

Citations

3
Fibrosis‐on‐Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease DOI Creative Commons
Emma M. Streutker, Utku Devamoglu, Madelon C Vonk

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(21)

Published: March 27, 2024

Fibrosis, which is primarily marked by excessive extracellular matrix (ECM) deposition, a pathophysiological process associated with many disorders, ultimately leads to organ dysfunction and poor patient outcomes. Despite the high prevalence of fibrosis, currently there exist few therapeutic options, importantly, paucity in vitro models accurately study fibrosis. This review discusses multifaceted nature fibrosis from viewpoint developing organ-on-chip (OoC) disease models, focusing on five key features: ECM component, inflammation, mechanical cues, hypoxia, vascularization. The potential OoC technology explored for better modeling these features context studying fibrotic diseases interplay between various emphasized. paper reviews how organ-specific are modeled platforms, elements included existing avenues novel research directions highlighted. Finally, this concludes perspective address current gap respect inclusion multiple yield more sophisticated relevant an format.

Language: Английский

Citations

3