Single voxel autocorrelation reflects hippocampal function in temporal lobe epilepsy DOI Creative Commons
Nichole R. Bouffard, Sam Audrain, Ali Golestani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Abstract We have previously shown that analyses of autocorrelation BOLD signal applied to single voxels in healthy controls can identify gradients temporal dynamics throughout the hippocampal long-axis are related behavior. A question remains is how changes functional and structural integrity brain affect voxel autocorrelation. In this study we investigate affected by dysfunction investigating a population patients with unilateral lobe epilepsy (TLE). Many TLE mesial sclerosis (MTS), characterized scarring neuronal loss particularly anterior hippocampus. Here compared left right TLE, some without MTS, controls. our method data-driven clustering approach segment hippocampus based on found had slower (i.e., higher autocorrelation) controls, anterior-medial portion This was true for both epileptogenic non-epileptogenic hemispheres. also evaluated extent cluster preservation spatial overlap controls) patient clusters relationship verbal visuospatial memory. greater better memory performance. Surprisingly, did not find any effect MTS autocorrelation, despite associated condition. These results suggest may be functional, rather than structural, integrity.

Language: Английский

Using baseline MRI radiomic features to predict the efficacy of repetitive transcranial magnetic stimulation in Alzheimer’s patients DOI
Chandan Saha, Chase R. Figley, Brian Lithgow

et al.

Medical & Biological Engineering & Computing, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Language: Английский

Citations

0
Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation DOI
Nichole R. Bouffard, Ali Golestani, Iva K. Brunec

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(6), P. 3265 - 3283

Published: Dec. 27, 2022

Abstract During navigation, information at multiple scales needs to be integrated. Single-unit recordings in rodents suggest that gradients of temporal dynamics the hippocampus and entorhinal cortex support this integration. In humans, representation are observed, such granularity represented increases along long axis hippocampus. The neural underpinnings gradient however, still unknown. Current research is limited by coarse fMRI analysis techniques obscure activity individual voxels, preventing investigation how moment-to-moment changes brain signal organized they related behavior. Here, we measured stability single voxels over time uncover previously unappreciated cortex. Using our novel, voxel autocorrelation technique, show a medial-lateral hippocampal gradient, as well continuous anterolateral-posteromedial extent. Importantly, anterior-medial was modulated navigational difficulty, providing first evidence relevant for This work opens door future on within these structures integration goal-directed

Language: Английский

Citations

12
Causal role of the angular gyrus in insight-driven memory reconfiguration DOI Creative Commons
Anna-Maria Grob, Hendrik Heinbockel, Branka Milivojevic

et al.

eLife, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 26, 2024

Maintaining an accurate model of the world relies on our ability to update memory representations in light new information. Previous research integration information into mainly focused hippocampus. Here, we hypothesized that angular gyrus, known be involved episodic and imagination, plays a pivotal role insight-driven reconfiguration representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) over left gyrus or sham before gaining insight relationship between previously separate life-like animated events narrative-insight task. During task, also underwent EEG recording their for linked non-linked was assessed shortly thereafter. Our results show cTBS decreased linking reduced advantage relative events. At neural level, targeting centro-temporal coupling with frontal regions abolished insight-induced representational changes via indicating impaired reconfiguration. Further, group showed resembled patterns observed events, suggesting failed pruning narrative memory. Together, findings demonstrate causal insight-related reconfigurations.

Language: Английский

Citations

1
Differential involvement of the anterior and posterior hippocampus, parahippocampus, and retrosplenial cortex in making precise judgments of spatial distance and object size for remotely acquired memories of environments and objects DOI

Marilyne Ziegler,

Zhong‐Xu Liu, Jessica S. Arsenault

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(18), P. 10139 - 10154

Published: July 29, 2023

Abstract The hippocampus is known to support processing of precise spatial information in recently learned environments. It less clear, but crucial for theories systems consolidation, know whether it also supports familiar environments long ago and such precision extends objects numbers. In this fMRI study, we asked participants make progressively more refined distance judgments among well-known Toronto landmarks (whether landmark A closer B or C) examine hippocampal involvement. We tested the was similarly engaged estimating magnitude regarding sizes animals found that only judgment. Activation greater lasted longer posterior than anterior hippocampus, which instead showed modulation as discrimination between distances became fine grained. These findings suggest have different functions are influenced differently by estimation differential distance. Similarly, parahippocampal-place-area retrosplenial cortex were involved condition. By contrast, activation intraparietal sulcus modulated all conditions. Therefore, our study idea related structures implicated retrieving operating even on remote memories whenever required, posted some consolidation.

Language: Английский

Citations

3
Causal role of the angular gyrus in insight-driven memory reconfiguration DOI Creative Commons
Anna-Maria Grob, Hendrik Heinbockel, Branka Milivojevic

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Nov. 15, 2023

Maintaining an accurate model of the world relies on our ability to update memory representations in light new information. Previous research integration information into mainly focused hippocampus. Here, we hypothesized that angular gyrus, known be involved episodic and imagination, plays a pivotal role insight-driven reconfiguration representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) over left gyrus or sham before gaining insight relationship between previously separate life-like animated events narrative-insight task. During task, also underwent EEG recording their for linked non-linked was assessed shortly thereafter. Our results show cTBS decreased linking reduced advantage relative events. At neural level, targeting centro-temporal coupling with frontal regions abolished insight-induced representational changes via indicating impaired reconfiguration. Further, group showed resembled patterns observed events, suggesting failed pruning narrative memory. Together, findings demonstrate causal insight-related reconfigurations.

Language: Английский

Citations

2
Causal role of the angular gyrus in insight-driven memory reconfiguration DOI Open Access
Anna-Maria Grob, Hendrik Heinbockel, Branka Milivojevic

et al.

Published: Feb. 14, 2024

Maintaining an accurate model of the world relies on our ability to update memory representations in light new information. Previous research integration information into mainly focused hippocampus. Here, we hypothesized that angular gyrus, known be involved episodic and imagination, plays a pivotal role insight-driven reconfiguration representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) over left gyrus or sham before gaining insight relationship between previously separate life-like animated events narrative-insight task. During task, also underwent EEG recording their for linked non-linked was assessed shortly thereafter. Our results show cTBS decreased linking reduced advantage relative events. At neural level, targeting centro-temporal coupling with frontal regions abolished insight-induced representational changes via indicating impaired reconfiguration. Further, group showed resembled patterns observed events, suggesting failed pruning narrative memory. Together, findings demonstrate causal insight-related reconfigurations.

Language: Английский

Citations

0
Causal role of the angular gyrus in insight-driven memory reconfiguration DOI Creative Commons
Anna-Maria Grob, Hendrik Heinbockel, Branka Milivojevic

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 18, 2023

Abstract Maintaining an accurate model of the world relies on our ability to update memory representations in light new information. Previous research integration information into mainly focused hippocampus. Here, we hypothesized that angular gyrus, known be involved episodic and imagination, plays a pivotal role insight-driven reconfiguration representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) over left gyrus or sham before gaining insight relationship between previously separate life-like animated events narrative-insight task. During task, also underwent EEG recording their for linked non-linked was assessed shortly thereafter. Our results show cTBS decreased linking reduced advantage relative events. At neural level, targeting centro-temporal coupling with frontal regions abolished insight-induced representational changes via indicating impaired reconfiguration. Further, group showed resembled patterns observed events, suggesting failed pruning narrative memory. Together, findings demonstrate causal insight-related reconfigurations.

Language: Английский

Citations

0
Causal role of the angular gyrus in insight-driven memory reconfiguration DOI Open Access
Anna-Maria Grob, Hendrik Heinbockel, Branka Milivojevic

et al.

Published: Nov. 15, 2023

Maintaining an accurate model of the world relies on our ability to update memory representations in light new information. Previous research integration information into mainly focused hippocampus. Here, we hypothesized that angular gyrus, known be involved episodic and imagination, plays a pivotal role insight-driven reconfiguration representations. To test this hypothesis, participants received continuous theta burst stimulation (cTBS) inhibiting left gyrus or sham before gaining insight relationship between previously separate life-like animated events narrative-insight task. During task, also underwent EEG recording their for linked non-linked was assessed shortly thereafter. Our results show cTBS decreased linking reduced advantage relative events. At neural level, cTBS-induced inhibition centro-temporal coupling with frontal regions abolished insight-induced representational changes via indicating impaired reconfiguration. Further, group showed resembled patterns observed events, suggesting failed pruning narrative memory. Together, findings demonstrate causal insight-related reconfigurations.

Language: Английский

Citations

0
Single voxel autocorrelation reflects hippocampal function in temporal lobe epilepsy DOI Creative Commons
Nichole R. Bouffard, Sam Audrain, Ali Golestani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Abstract We have previously shown that analyses of autocorrelation BOLD signal applied to single voxels in healthy controls can identify gradients temporal dynamics throughout the hippocampal long-axis are related behavior. A question remains is how changes functional and structural integrity brain affect voxel autocorrelation. In this study we investigate affected by dysfunction investigating a population patients with unilateral lobe epilepsy (TLE). Many TLE mesial sclerosis (MTS), characterized scarring neuronal loss particularly anterior hippocampus. Here compared left right TLE, some without MTS, controls. our method data-driven clustering approach segment hippocampus based on found had slower (i.e., higher autocorrelation) controls, anterior-medial portion This was true for both epileptogenic non-epileptogenic hemispheres. also evaluated extent cluster preservation spatial overlap controls) patient clusters relationship verbal visuospatial memory. greater better memory performance. Surprisingly, did not find any effect MTS autocorrelation, despite associated condition. These results suggest may be functional, rather than structural, integrity.

Language: Английский

Citations

0