Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus

European Heart Journal, Journal Year: 2022, Volume and Issue: 43(11), P. 1157 - 1172

Published: Feb. 7, 2022

Abstract Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), condition characterized by the persistence COVID-19 symptoms beyond 3 months, is anticipated to substantially alter lives millions people globally. Cardiopulmonary including chest pain, shortness breath, fatigue, and autonomic manifestations such postural orthostatic tachycardia are common associated with significant disability, heightened anxiety, public awareness. A range cardiovascular (CV) abnormalities has been reported among patients acute phase include myocardial inflammation, infarction, right ventricular dysfunction, arrhythmias. Pathophysiological mechanisms for delayed complications still poorly understood, dissociation seen between ongoing objective measures cardiopulmonary health. long-term trajectory many chronic cardiac diseases which abundant in those at risk severe disease. In this review, we discuss definition its epidemiology, an emphasis on symptoms. We further review pathophysiological underlying CV injury, sequelae, impact multiorgan propose possible model referral post-COVID-19 services future directions research priorities clinical trials that currently underway evaluate efficacy treatment strategies sequelae.

Language: Английский

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Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

Pathogens, Journal Year: 2022, Volume and Issue: 11(2), P. 269 - 269

Published: Feb. 19, 2022

Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise on post-COVID persisting for at least 12 months. We searched PubMed and Embase papers reporting one-year follow-up results of published by 6 November 2021. Random-effects meta-analyses were conducted estimate pooled prevalence specific Eighteen reported data 8591 included. Fatigue/weakness (28%, 95% CI: 18–39), dyspnoea (18%, 13–24), arthromyalgia (26%, 8–44), depression (23%, 12–34), anxiety (22%, 15–29), memory loss (19%, 7–31), concentration difficulties 2–35), insomnia (12%, 7–17) most prevalent follow-up. Existing suggested female patients those with more severe initial illness likely sequelae after one year. demonstrated a sizeable proportion still experience residual involving various body systems year later. There is an urgent need elucidating pathophysiologic mechanisms developing testing targeted interventions long-COVID patients.

Language: Английский

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Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study

The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 10(9), P. 863 - 876

Published: May 11, 2022

Language: Английский

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Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis

Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(5), P. 657 - 666

Published: Feb. 3, 2022

Language: Английский

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Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2452 - 2468.e16

Published: June 13, 2022

COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection found white-matter-selective in mice humans. Following mild mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, myelin loss were evident together with elevated CSF cytokines/chemokines including CCL11. Systemic CCL11 administration specifically caused neurogenesis. Concordantly, humans lasting post-COVID exhibit levels. Compared SARS-CoV-2, influenza similar patterns reactivity, oligodendrocyte loss, at early time points, but after influenza, only pathology persisted. These findings illustrate neuropathophysiology cancer therapy may contribute to impairment following even COVID.

Language: Английский

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Long-COVID in children and adolescents: a systematic review and meta-analyses

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 23, 2022

Abstract The objective of this systematic review and meta-analyses is to estimate the prevalence long-COVID in children adolescents present full spectrum symptoms after acute COVID-19. We have used PubMed Embase identify observational studies published before February 10th, 2022 that included a minimum 30 patients with ages ranging from 0 18 years met National Institute for Healthcare Excellence (NICE) definition long-COVID, which consists both ongoing (4 12 weeks) post-COVID-19 (≥ symptoms. Random-effects were performed using MetaXL software pooled 95% confidence interval (CI). Heterogeneity was assessed I 2 statistics. Preferred Reporting Items Systematic Reviewers Meta-analysis (PRISMA) reporting guideline followed (registration PROSPERO CRD42021275408). literature search yielded 8373 publications, 21 inclusion criteria, total 80,071 included. 25.24%, most prevalent clinical manifestations mood (16.50%), fatigue (9.66%), sleep disorders (8.42%). Children infected by SARS-CoV-2 had higher risk persistent dyspnea, anosmia/ageusia, and/or fever compared controls. Limitations analyzed include lack standardized definitions, recall, selection, misclassification, nonresponse loss follow-up, high level heterogeneity.

Language: Английский

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The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(6), P. 100663 - 100663

Published: June 1, 2022

Language: Английский

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Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 5, 2022

About 10% of people infected by severe acute respiratory syndrome coronavirus 2 experience post COVID-19 disease. We analysed data from 968 adult patients (5350 person-months) with a confirmed infection enroled in the ComPaRe long COVID cohort, disease prevalent prospective e-cohort such France. Day-by-day prevalence symptoms was determined patients' responses to Long Symptom Tool, validated self-reported questionnaire assessing 53 symptoms. Among symptomatic after months, 85% still reported one year their symptom onset. Evolution showed decreasing over time for 27/53 (e.g., loss taste/smell); stable 18/53 dyspnoea), and an increasing 8/53 paraesthesia). The impact on lives began 6 months Our results are importance understand natural history

Language: Английский

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Post-acute sequelae of covid-19 six to 12 months after infection: population based study

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e071050 - e071050

Published: Oct. 13, 2022

Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, risk factors, examine the association with general health working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years confirmed SARS-CoV-2 infection between October 2020 March 2021 notified authorities in four geographically defined regions southern Germany. Participants 50 457 patients were invited participate study, whom 053 (24%) responded 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted covid-19; follow-up time 8.5 months) could be included analyses. Main outcome measures Symptom frequencies (six versus before infection), severity clustering, associations recovery Results The fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% 38.1%) neurocognitive impairment (31.3% (3561/11 361), 30.5% 32.2%) contributed most reduced capacity, but chest symptoms, anxiety/depression, headache/dizziness, pain syndromes also prevalent relevant for some differences according sex age. Considering new at least moderate daily life ≤80% recovered or overall estimate was 28.5% (3289/11 536, 27.7% 29.3%) among participants 6.5% (3289/50 457) infected adult population (assuming that all non-responders had completely recovered). true value is likely these estimates. Conclusions Despite limitation a low response rate possible selection recall biases, this suggests considerable burden self-reported post-acute sequelae, notably impairment, even young middle adults mild substantial impact on Trial registration German registry clinical studies DRKS 00027012.

Language: Английский

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ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

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