Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107605 - 107605
Published: April 1, 2025
Language: Английский
The Lancet Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 100947 - 100947
Published: Sept. 1, 2024
Language: Английский
Citations
40
Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 1912 - 1912
Published: July 27, 2023
The global burden of bacterial resistance remains one the most serious public health concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffective due to MDR multiple classes antibiotics, but also contribute selection and spread antimicrobial resistance. Both WHO ECDC consider carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa (CRPA), Acinetobacter baumannii (CRAB) highest priority. ability form biofilm acquisition drug genes, particular carbapenems, have made these pathogens particularly difficult treat. They are a growing cause healthcare-associated infections significant threat health, associated with high mortality rate. Moreover, co-colonization was found predictor for in-hospital mortality. Importantly, they potential using mobile genetic elements. Given current situation, it is clear that finding new ways combat can no longer delayed. aim this review evaluate literature on how AMR. highlights importance rational use antibiotics need implement stewardship principles prevent transmission drug-resistant organisms healthcare settings. Finally, discusses advantages limitations alternative therapies treatment “titans” antibiotic
Language: Английский
Citations
41
Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(10), P. 897 - 910
Published: Sept. 25, 2023
Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.1.1) are present in bacteria, α-, β-, γ- and ι-CAs. They play relevant functions related to CO2, HCO3-/H+ ions homeostasis, being involved metabolic biosynthetic pathways, pH regulation, represent virulence survival factors for bacteria various niches. Bacterial CAs started be considered druggable targets last decade, as their inhibition impairs survival, growth, these pathogens.Significant advances were registered years designing effective inhibitors sulfonamide type Helicobacter pylori α-CA, Neisseria gonorrhoeae vacomycin-resistant enterococci (VRE) α- γ-CAs, which vivo validation has also been achieved. MIC-s range 0.25-4.0 µg/mL wild drug resistant N. strains, 0.007-2.0 VRE observed some 1,3,4-thiadiazole-2-sulfonamides, acetazolamide was gut decolonization from VRE.Targeting bacterial other pathogens, among Vibrio cholerae, Mycobacterium tuberculosis, Brucella suis, Salmonella enterica serovar Typhimurium, Legionella pneumophila, Porphyromonas gingivalis, Clostridium perfringens, Streptococcus mutans, Burkholderia pseudomallei, Francisella tularensis, Escherichia coli, Mammaliicoccus (Staphylococcus) sciuri, Pseudomonas aeruginosa, may lead novel antibacterials devoid resistance problems.
Language: Английский
Citations
31
Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2115 - 2115
Published: Aug. 19, 2023
Acinetobacter baumannii is a Gram-negative coccobacillus with exceptional survival skills in an unfavorable environment and the ability to rapidly acquire antibiotic resistance, making it one of most successful hospital pathogens worldwide, representing serious threat public health. The global dissemination A. driven by several lineages named ‘international clones high risk’ (ICs), two which were first revealed 1970s. Epidemiological surveillance crucial tool for controlling spread this pathogen, currently increasingly involves whole genome sequencing. However, assignment particular isolate some IC based on its genomic sequence not always straightforward requires computational from researchers, while definitions found literature are sometimes controversial. In review, we will focus typing tools suitable determination, provide data easily determine MLST type (ST) intrinsic blaOXA-51-like gene variants, discuss history current nine known ICs, IC1-IC9, investigate representation ICs databases. cgMLST profiles, as well OXA-51-like presence provided all isolates available GenBank. possible emergence novel international clone, IC10, be discussed.
Language: Английский
Citations
26
Drugs, Journal Year: 2023, Volume and Issue: 83(13), P. 1245 - 1252
Published: July 31, 2023
Language: Английский
Citations
25
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6814 - 6814
Published: June 21, 2024
represents a significant concern in nosocomial settings, particularly critically ill patients who are forced to remain hospital for extended periods. The challenge of managing and preventing this organism is further compounded by its increasing ability develop resistance due extraordinary genomic plasticity, response adverse environmental conditions. Its recognition as public health risk has provided impetus the identification new therapeutic approaches infection control strategies. Indeed, currently used antimicrobial agents gradually losing their efficacy, neutralized newer mechanisms bacterial resistance, especially carbapenem antibiotics. A deep understanding underlying molecular urgently needed shed light on properties that allow
Language: Английский
Citations
13
Antibiotics, Journal Year: 2024, Volume and Issue: 13(6), P. 506 - 506
Published: May 29, 2024
It is estimated that antimicrobial resistance (AMR) responsible for nearly 5 million human deaths worldwide each year and will reach 10 by 2050. Carbapenem-resistant Acinetobacter baumannii (CRAB) infections represent the fourth-leading cause of death attributable to globally, but a standardized therapy still lacking. Among antibiotics under consideration, Sulbactam/durlobactam seems be best candidate replace current back-bone agents. Cefiderocol could play pivotal role within combination regimens. Due toxicity pharmacokinetics/pharmacodynamics (PK/PD) limitations, colistin (or polymyxin B) should used as an alternative agent (when no other options are available). Tigecycline minocycline) fosfomycin suitable partners both NBLs. Randomized clinical trials (RCTs) needed better evaluate NBLs in CRAB infection treatment compare efficacy tigecycline partner antibiotics. Synergism tested between “old” drugs (rifampicin trimethoprim/sulfamethoxazole). Huge efforts made accelerate pre-clinical studies on safer candidates with improved lung activity, well iv rifabutin formulation. In this narrative review, we focused antibiotic view newly developed β-lactam agents (NBLs).
Language: Английский
Citations
12
Future Microbiology, Journal Year: 2024, Volume and Issue: 19(7), P. 563 - 576
Published: March 1, 2024
Sulbactam–durlobactam is a pathogen-targeted β-lactam/β-lactamase inhibitor combination that has been approved by the US FDA for treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused susceptible isolates Acinetobacter baumannii–calcoaceticus complex (ABC) in patients 18 years age older. Sulbactam penicillin derivative with antibacterial activity against but prone to hydrolysis β-lactamases encoded contemporary isolates. Durlobactam diazabicyclooctane β-lactamase Ambler classes A, C D serine restores sulbactam both vitro vivo multidrug-resistant ABC. promising alternative therapy serious infections, which can have high rates mortality.
Language: Английский
Citations
10
Genes, Journal Year: 2024, Volume and Issue: 15(4), P. 458 - 458
Published: April 5, 2024
Acinetobacter baumannii (Ab) has increasingly been identified as a cause of hospital-acquired infections and epidemics. The rise carbapenem-resistant (CRAB) poses significant challenges in treatment. Nosocomial outbreaks linked to CRAΒ A. strains have reported worldwide, including Greece. This study aimed analyze the molecular epidemiology trends multidrug-resistant isolates tertiary hospital Athens, A total 43 clinical extensively drug-resistant (XDRAB), pan-drug-resistant (PDRAB), CRAB were collected from patients suffering blood infection, hospitalized between 2016 2020 at internal medicine clinics ICU. A.baumannii underwent testing for Ambler class B D carbapenemases detection ISAba1, typed, initially, using pulsed-field gel electrophoresis, and, subsequently, sequence-based typing multiplex PCR determine European Clone lineages. blaOXA-23 gene accompanied by ISAba1 was prevalent nearly all isolates, except one carrying blaOXA-58. intrinsic blaOXA-51-like found isolates. No (VIM, NDM) detected. Isolates grouped into four PF-clusters no one-cluster spread documented, consistent with absence outbreak. indicated that XDR/PDR-CRAB predominantly produce OXA-23 carbapenemase belong II. Further research is needed understand distribution resistant bacteria develop effective prevention control strategies.
Language: Английский
Citations
7
Eurosurveillance, Journal Year: 2024, Volume and Issue: 29(15)
Published: April 11, 2024
Background As increasing antibiotic resistance in Acinetobacter baumannii poses a global healthcare challenge, understanding its evolution is crucial for effective control strategies. Aim We aimed to evaluate the epidemiology, antimicrobial susceptibility and main mechanisms of spp. Spain 2020, explore temporal trends A. . Methods collected 199 single-patient clinical isolates 2020 from 18 Spanish tertiary hospitals. Minimum inhibitory concentrations (MICs) nine antimicrobials were determined. Short-read sequencing was performed all isolates, targeted long-read Resistance mechanisms, phylogenetics clonality assessed. Findings on rates infection types compared with data 2000 2010. Results Cefiderocol colistin exhibited highest activity against , although has significantly declined over 2 decades. non- strains highly susceptible most tested antibiotics. Of 47.5% (56/118) multidrug-resistant (MDR). Phylogeny clonal relationship analysis revealed five prevalent international clones, notably IC2 (ST2, n = 52; ST745, 4) IC1 (ST1, 14), some episodes dissemination. Genes bla OXA-23 OXA-58 OXA-24/40 identified 49 (41.5%), eight (6.8%) one (0.8%) respectively. IS Aba 1 found upstream gene (a OXA-51 -like ) 10 isolates. Conclusions The emergence OXA-23-producing ST1 ST2, predominant MDR lineages, shows pivotal shift carbapenem-resistant (CRAB) epidemiology Spain. Coupled increased resistance, these changes underscore notable alterations regional dynamics.
Language: Английский
Citations
6