Associations between triglyceride-glucose index combined with waist circumference and heart failure in individuals with different body mass indices: a cross-sectional study using NHANES 2011–2020 data DOI Creative Commons
Chengyi Wang, Jinxi Wang,

Xinqing Li

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 7, 2025

The incidence of heart failure (HF), a cardiovascular disease, has been widely reported to be gradually increasing. Although the triglyceride-glucose (TyG) index is associated with risk HF, this relationship may affected by differences in nutritional status among individuals varying levels obesity. Waist circumference combined TyG more accurately HF. This study analyzed data from 8769 participants 2011–2020 National Health and Nutrition Examination Survey (NHANES). After weighting data, multivariable logistic regressions were used calculate associations between HF TyG-waist (TyG-WC) indices adults different body mass (BMIs). Restricted cubic splines employed assess for linear or nonlinear relationships. Receiver operating characteristic (ROC) curves demonstrate efficacy models indices. Net Reclassification Index (NRI) was measure improvement TyG-WC relative models. Integrated Discriminant Improvement (IDI) supports conclusion. positively (TyG: odds ratio [OR], 1.765; 95% CI], 1.390–2.242; P < 0.001; TyG-WC: OR, 1.003; CI, 1.002–1.004; 0.001), except In Model 4 (OR, 1.238; 0.941–1.629; = 0.124). BMI categorize population into normal underweight overweight obese groups. groups, (OR) increased as value increased. However, high low ORs. According ROC, NRI, IDI analyses, weight groups (area under curve [AUC]: 0.6724; CI: 0.4991-0.6400), whereas alone not (AUC: 0.5695; 0.6115–0.7334). 4, adjusted all covariates, had slightly better ability than (NRI: -0.4112; -0.6818- -0.1406; 0.05; IDI: -0.0072; 95%CI: -0.0228-0.0083; 0.36256). populations, 0.3089; 0.1726–0.4451; 0.0084; 0.0017–0.0151; 0.05). sensitivity only 41.8%. association these two influenced BMI. normal-weight higher imply improved status. Therefore, should WC both can HF; however, less sensitive when alone.

Language: Английский

Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases DOI Open Access
Virginia Actis Dato, Stephan Lange, Yoshitake Cho

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1211 - 1211

Published: Jan. 19, 2024

This comprehensive review explores the critical role of fatty acid (FA) metabolism in cardiac diseases, particularly heart failure (HF), and implications for therapeutic strategies. The heart’s reliance on ATP, primarily sourced from mitochondrial oxidative metabolism, underscores significance metabolic flexibility, with oxidation (FAO) being a dominant source. In HF, shifts occur an altered FA uptake FAO, impacting function contributing to disease progression. Conditions like obesity diabetes also lead disturbances, resulting cardiomyopathy marked by over-reliance dysfunction, lipotoxicity. Therapeutic approaches targeting diseases have evolved, focusing inhibiting or stimulating FAO optimize energetics. Strategies include using CPT1A inhibitors, PPARα agonists, enhancing biogenesis function. However, effectiveness varies, reflecting complexity remodeling HF. Hence, treatment strategies should be individualized, considering that energy is intricate tightly regulated. aim overall function, recognizing pivotal FAs need further research develop effective therapies, promising new improve

Language: Английский

Citations

19
Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases DOI Creative Commons

Haipeng Jie,

Jingjing Zhang,

Shuzhen Wu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Sustained production of reactive oxygen species (ROS) and an imbalance in the antioxidant system have been implicated development cardiovascular diseases (CVD), especially when combined with diabetes, hypercholesterolemia, other metabolic disorders. Among them, NADPH oxidases (NOX), including NOX1-5, are major sources ROS that mediate redox signaling both physiological pathological processes, fibrosis, hypertrophy, remodeling. Recent studies demonstrated mitochondria produce more proteins energy response to adverse stress, corresponding increase superoxide radical anions. Novel NOX4-mediated modulatory mechanisms considered crucial for maintaining metabolism homeostasis during states. In this review, we integrate latest data elaborate on interactions between oxidative stress various CVD, aiming elucidate higher incidence CVD individuals Furthermore, correlations NOX ferroptosis, based metabolism, preliminarily discussed. Further discoveries these might promote novel therapeutic drugs targeting their crosstalk potentially offering efficient management strategies CVD.

Language: Английский

Citations

2
Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine DOI
Ashot Avagimyan, Nana Pogosova, Federica Fogacci

et al.

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: 418, P. 132663 - 132663

Published: Oct. 18, 2024

Language: Английский

Citations

17
Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism DOI
Ting Wan, Yucheng Liang,

Tianwen Wei

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

1
Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKα2 DOI
Xue Han, Qiaojuan Shi,

Yu Tu

et al.

Circulation Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

BACKGROUND: Pathological cardiac hypertrophy can result in heart failure. Protein dephosphorylation plays a primary role the mediation of various cellular processes cardiomyocytes. Here, we investigated effects protein tyrosine phosphatase, PRL2 (phosphatase regenerative liver 2), on pathological hypertrophy. METHODS: The knockout mice were subjected to angiotensin II infusion or transverse aortic constriction induce myocardial and dysfunction. RNA-sequencing analysis was performed explore underlying mechanisms. Mass spectrometry bio-layer interferometry assays used identify AMPKα2 (AMP-activated kinase α2) as an interacting PRL2. Mutant plasmids clarify how interacts dephosphorylates AMPKα2. RESULTS: A significant upregulation observed hypertrophic myocardium tissues patients with deficiency alleviated hypertrophy, fibrosis, dysfunction challenged constriction. Transcriptomic biochemical analyses showed that silence maintained AMPK T172 phosphorylation subsequent mitochondrial integrity II-challenged spectrometry-based interactome assay indicated subunit substrate Mechanistically, binds C-terminal domain then via its active site C46. Adeno-associated virus 9-mediated cardiomyocyte also protected function cardioprotective mice, but these benefits not −/− mice. CONCLUSIONS: This study reveals PRL2, novel AMPK-regulating promotes instability injury cardiomyocytes provides PLR2 potential target for future drug development treating

Language: Английский

Citations

1
Advances in the activity of resveratrol and its derivatives in cardiovascular diseases DOI

Yaling Peng,

Xing Zheng, Si Zhang

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(2)

Published: Feb. 1, 2025

Abstract Cardiovascular diseases (CVDs), the leading cause of human death worldwide, are that affect heart and blood vessels include arrhythmias, coronary atherosclerotic disease, hypertension, so on. Resveratrol (RSV) is a natural nonflavonoid phenolic compound with antioxidant, anti‐inflammatory, anticancer, cardiovascular protection functions. RSV has shown significant protective effects against CVD. However, RSV's clinical application limited by its tendency to be oxidized metabolized easily. Therefore, it necessary optimize structure. This review will introduce activity, synthesis, structure–activity relationships derivatives, mechanism action in CVDs recent years.

Language: Английский

Citations

1
Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction DOI Creative Commons
Feng Shao,

Johanna Wieland,

Yixin Wang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Abstract Background Nucleoside diphosphate kinase B (NDPKB) deficiency in endothelial cells (ECs) promotes the activation of hexosamine biosynthesis pathway (HBP), leading to vascular damage retina. The aim this study was investigate consequences NDPKB mouse heart. Methods deficient mice were used study. Echocardiography employed assess cardiac function vivo. Characterization contractility hiPSC-derived cardiomyocytes (hiPSC-CMs) measured with IonOptix system. Immunoblotting and immunofluorescence carried out analyze expression localization proteins cultured left ventricles (LVs). Results displayed impaired glucose tolerance increased heart weight compared controls. Echocardiographic analysis revealed an increase diastolic diameter ventricular posterior wall (LVPW), a decrease early mitral valve E E′ wave, ratios E/A E′/A′ hearts, suggesting hypertrophy dysfunction. In line dysfunction, phosphorylation myocardial phospholamban (PLN) sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 2 (SERCA2) LVs significantly reduced. Moreover, accumulation collagen, fibronectin as well upregulation transforming growth factor β (TGF-β), detected LVs. addition, HBP its downstream O-GlcNAc cycle observed ECs (CECs) isolated from −/− mice. Furthermore, bipolar regulation identified CMs. decreased NDPKB-depleted CMs, while conditioned medium levels, along contractile relaxation dysfunction hiPSC-CMs, which attenuated by inhibiting activation. Conclusions Deficiency leads Our findings may highlight crucial role proper maintaining cardiovascular homeostasis.

Language: Английский

Citations

1
Exo-miR-144-3p as a promising diagnostic biomarker for depressive symptoms in heart failure DOI Creative Commons

Ruting Wang,

Kai Huang, Yuehua Feng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106415 - 106415

Published: Jan. 1, 2024

The prevalence of depression is higher in heart failure (HF) patients. Early screening depressive symptoms HF patients and timely intervention can help improve patients' quality life prognosis. This study aims to explore biomarkers for disease diagnosis by examining the expression profile serum exosomal miRNAs with symptoms. Serum RNA was isolated extracted from 6 (HF-DS) without (HF-NDS). High-throughput sequencing performed obtain miRNA profiles target genes were predicted screened differentially expressed miRNAs. Biological functions analyzed through Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). Subsequently, we collected RNAs HF-DS (n = 20) HF-NDS 20). selected results validated using reverse transcription quantitative polymerase chain reaction (RT-qPCR). Finally, diagnostic efficacy predicting evaluated receiver operating characteristic (ROC) curves. A total 19 significantly high-throughput sequencing, consisting 12 up-regulated 7 down-regulated RT-qPCR validation demonstrated that level exo-miR-144-3p group, levels exo-miR-625-3p exo-miR-7856-5p up-regulated. negatively correlated severity patients, area under curve (AUC) diagnosing 0.763. In this study, examined found lower associated more severe Exo-miR-144-3p a potential biomarker

Language: Английский

Citations

5
Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review DOI Open Access
Rosalinda Madonna, Filippo Biondi, Mattia Alberti

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116650 - 116650

Published: April 27, 2024

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a new class of glucose-lowering drugs traditionally used to control blood glucose levels in patients with type diabetes mellitus, have been proven reduce major adverse cardiovascular events, including death, heart failure irrespective ejection fraction and independently the hypoglycemic effect. Because their favorable effects on kidney outcomes, use has expanded all any combination mellitus 2, chronic disease failure. Although mechanisms explaining these system are not well understood, effectiveness conditions suggests that they act at intersection metabolic, renal cardiac axes, thus disrupting maladaptive vicious cycles while contrasting direct organ damage. In this systematic review we provide state art randomized controlled trials investigating effect SGLT2i outcomes and/or diabetes. We also discuss molecular targets signaling pathways potentially pharmacological agents, from clinical experimental perspective.

Language: Английский

Citations

5
Cardiotoxicity of tris(2-chloroethyl) phosphate exposure: Insights into the role of oxygen sensor mediated energy metabolism remodeling DOI
Ze Zhang,

Chuer Zheng,

Xinya Gu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137113 - 137113

Published: Jan. 5, 2025

Language: Английский

Citations

0