The pediatric gut bacteriome and virome in response to SARS-CoV-2 infection DOI Creative Commons
Antonia Piazzesi, Stefania Pane, Federica Del Chierico

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 22, 2024

Introduction Since the beginning of SARS-CoV-2 pandemic in early 2020, it has been apparent that children were partially protected from both infection and more severe forms disease. Many different mechanisms have proposed to explain this phenomenon, including children’s frequent exposure other upper respiratory infections vaccines, which inflammatory cytokines they are likely produce response infection. Furthermore, given presence intestine its ability infect enterocytes, combined with well described immunomodulatory capabilities microbiome, another potential contributing factor may be certain protective microbial members gut microbiota (GM). Methods We performed shotgun metagenomic sequencing profiled bacteriome virome GM pediatric patients compared healthy, age-matched subjects. Results found that, while do share some pro-inflammatory signatures adult patients, also possess a distinct signature bacteria previously negatively correlated infectivity COVID-19 severity. was associated higher fecal Cytomegalovirus load, shifts relative abundances bacteriophages GM. we address how preventative treatment antibiotics, common practice especially days pandemic, affected virome, as antimicrobial resistance virulence genes these patients. Discussion To our knowledge, is first study bacteriome, resistome antibiotics use.

Language: Английский

Microbial transmission in the social microbiome and host health and disease DOI Creative Commons
Amar Sarkar,

Cameron J.A. McInroy,

Siobhán Harty

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(1), P. 17 - 43

Published: Jan. 1, 2024

Language: Английский

Citations

38
Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches DOI Open Access

Andy Acevedo-Román,

Natalia Pagán-Zayas,

Liz I. Velázquez-Rivera

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9715 - 9715

Published: Sept. 8, 2024

The gut microbiota is one of the most critical factors in human health. It involves numerous physiological processes impacting host health, mainly via immune system modulation. A balanced microbiome contributes to gut’s barrier function, preventing invasion pathogens and maintaining integrity lining. Dysbiosis, or an imbalance microbiome’s composition disrupts essential various diseases. This narrative review summarizes key findings related modern multifactorial inflammatory conditions such as ulcerative colitis Crohn’s disease. addresses challenges posed by antibiotic-driven dysbiosis, particularly context C. difficile infections, development novel therapies like fecal transplantation biotherapeutic drugs combat these infections. An emphasis given restoration healthy through dietary interventions, probiotics, prebiotics, approaches for managing gut-related

Language: Английский

Citations

21
Gut microbiome affects the response to immunotherapy in non‐small cell lung cancer DOI Creative Commons
Shengnan Ren, Lingxin Feng, Haoran Liu

et al.

Thoracic Cancer, Journal Year: 2024, Volume and Issue: 15(14), P. 1149 - 1163

Published: April 4, 2024

Abstract Background Immunotherapy has revolutionized cancer treatment. Recent studies have suggested that the efficacy of immunotherapy can be further enhanced by influence gut microbiota. In this study, we aimed to investigate impact bacteria on effectiveness combining analysis clinical samples with validation in animal models. Methods order characterize diversity and composition microbiota its relationship response immune checkpoint inhibitors (ICIs), 16S ribosomal RNA (rRNA) GC–MS sequencing was performed 71 stool from patients advanced non‐small cell lung (NSCLC) prior treatment blockade (ICB). Furthermore, fecal transplantation (FMT) different into mice a subcutaneous tumor model established using Lewis line evaluate therapeutic effect PD‐1 varying Results The results demonstrated significant association between elevated ICIs, p < 0.05. Faecalibacterium markedly increased responders (R), accompanied short‐chain fatty acid (SCFA) levels, especially butanoic acid, acetic hexanoic Additionally, FMT R nonresponders (NR) could promote an anticancer reduce expression Ki‐67 cells tumors mice, Moreover, NR did not alter PD‐L1 tissues > consistently correlated optimistic prognosis NSCLC immunotherapy, which functionally mediated SCFAs. Conclusion findings present study indicated SCFAs is related immunotherapy. effectively delay progression, enhance thus providing evidence for improving patients.

Language: Английский

Citations

18
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation DOI Creative Commons
Fuyong Li, Anissa M. Armet, Katri Korpela

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a restoration strategy comprising diet that recapitulated key characteristics of non-industrialized dietary patterns (restore diet) bacterium rarely found in industrialized microbiomes (Limosilactobacillus reuteri) randomized controlled feeding trial healthy Canadian adults. The restore diet, despite reducing diversity, enhanced persistence L. reuteri strain from rural Papua New Guinea (PB-W1) redressed several features altered by industrialization. also beneficially microbiota-derived plasma metabolites implicated etiology Considerable cardiometabolic benefits were observed independently administration, which could be accurately predicted baseline diet-responsive features. findings suggest intervention targeted toward restoring can improve host-microbiome interactions likely underpin pathologies, guide recommendations development therapeutic nutritional strategies.

Language: Английский

Citations

6
Core microbe Bifidobacterium in the hindgut of calves improves the growth phenotype of young hosts by regulating microbial functions and host metabolism DOI Creative Commons

Yimin Zhuang,

Duo Gao, Wen Jiang

et al.

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 16, 2025

The growth and health of young ruminants are regulated by their gut microbiome, which can have lifelong consequences. Compared with subjective grouping, phenotypic clustering might be a more comprehensive approach to revealing the relationship between calf state core microbes. However, identification beneficial bacteria its internal mechanisms shaping host phenotype differentiation remains unclear. In this study, calves were divided into two clusters, cluster1 cluster2, based on 29 indicators using cluster analysis. Calves in cluster2 showed better performance, including higher body weight (BW), average daily gain (ADG), dry matter intake (DMI), as well serum high level total superoxide dismutase (T-SOD), interleukin-6 (IL-6), insulin-like factor-1 (IGF-1) compared those cluster1. Multi-omics was used detect microbial features among different clusters. Distinct differences observed clustered microbiomes, diversity composition. close relationships blood metabolites, microbiome also confirmed. Bifidobacterium members dominant contributors metabolic functions abundance. Furthermore, pathways involved carbohydrate degradation, glycolysis, biosynthesis propionate proteins active, while methane production inhibited. addition, richness hindgut resistome lower than isolation culture strain, mice experiment, indicated that B. longum 1109 from feces could promote hosts, enhance immunity antioxidation, improve development hindgut. summary, analysis has proved feasible reliable for identifying subgroups calves, prompting further exploration host-microbiome interactions. microbe may play crucial probiotic role differentiation. This study enhances our comprehension how shapes provides new insights manipulation colonizers performance productivity ruminants. Video Abstract.

Language: Английский

Citations

3
The role of propionic acid as a feed additive and grain preservative on weanling pig performance and digestive health DOI

Kathryn Ruth Connolly,

Torres Sweeney, Dillon P. Kiernan

et al.

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116237 - 116237

Published: Jan. 1, 2025

Language: Английский

Citations

2
Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer DOI Open Access
Camelia Munteanu, Betty Schwartz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

Citations

13
Probiotics: Shaping the gut immunological responses DOI Creative Commons
Eirini Filidou, Leonidas Kandilogiannakis, Anne Shrewsbury

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(15), P. 2096 - 2108

Published: April 19, 2024

Probiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among most popular and adequately studied probiotics bacteria from families

Language: Английский

Citations

12
Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition DOI Creative Commons
Lingyan Ma, Wentao Lyu, Tao Zeng

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(4)

Published: May 14, 2024

Abstract The duck gastrointestinal tract (GIT) harbors an abundance of microorganisms that play important role in health and production. Here, we constructed the first relatively comprehensive gut microbial gene catalog (24 million genes) 4437 metagenome‐assembled genomes using 375 GIT metagenomic samples from four different breeds across five intestinal segments under two distinct rearing conditions. We further characterized region‐specific taxonomy their assigned functions, as well temporal development maturation microbiome. Our analysis revealed similarity within microbiota foregut hindgut compartments, but distinctive taxonomic functional differences between segments. In addition, found a significant shift composition newly hatched ducks (3 days), followed by increased diversity enhanced stability growth stages (14, 42, 70 indicating develops into mature stable community host matures. Comparing impact conditions (with without water) on cecal communities bacterial capacity for lipopolysaccharide biosynthesis was significantly had free access to water, leading accumulation pathogenic bacteria antibiotic‐resistance genes. Taken together, our findings expand understanding microbiome signatures linked regional, development, ducks, which highlight poultry

Language: Английский

Citations

12
Faecalibacterium duncaniae as a novel next generation probiotic against influenza DOI Creative Commons

Loïc Chollet,

Séverine Heumel,

Lucie Deruyter

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

The gut-lung axis is critical during viral respiratory infections such as influenza. Gut dysbiosis infection translates into a massive drop of microbially produced short-chain fatty acids (SCFAs). Among them, butyrate important influenza suggesting that microbiome-based therapeutics targeting might hold promises. butyrate-producing bacterium Faecalibacterium duncaniae (formerly referred to F. prausnitzii ) an emerging probiotic with several health-promoting characteristics. To investigate the potential effects on outcomes, mice were gavaged live (A2-165 or I-4574 strains) five days before infection. Supplementation was associated less severe disease, lower pulmonary load, and levels lung inflammation. supplementation impacted gut induced by infection, assessed 16S rRNA sequencing. Interestingly, administration recovery in SCFAs (including butyrate) infected animals. form more potent pasteurized improving outcomes. Lastly, partially protected against secondary (systemic) bacterial We conclude serve novel next generation acute diseases.

Language: Английский

Citations

11