Altered metabolism in cancer: insights into energy pathways and therapeutic targets

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

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Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 498 - 498

Published: Jan. 9, 2025

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection metabolism particularly significant, it plays a critical role energy regulation and distribution within organisms. Over recent decades, has emerged relevant focus studies biological regulation, especially following its recognition hallmark cancer. This shift broadened cancer research beyond strictly genetic perspectives. interaction between carcinogenesis involves the essential metabolic pathways, such glycolysis Krebs cycle, well involvement redox-active components like specific amino acids cofactors. feedback mechanisms linking highlight development patterns that enhance flexibility adaptability tumor processes, influencing larger-scale phenomena circadian rhythms epigenetics.

Language: Английский

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Field guide to Nath’s research work on ATP synthesis and hydrolysis

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105461 - 105461

Published: April 1, 2025

Adenosine triphosphate (ATP) is the universal biological energy source that participates in most prevalent chemical reactions all cell life through vital processes of oxidative phosphorylation (OXPHOS) and photosynthesis. Its synthesis utilisation an area basic research has seen significant progress over last three decades. A series Nath's publications 1990s culminated a detailed description molecular mechanism ATP FO F1 portions FOF1-ATP synthase which from transmembrane ion gradients are converted into F1. Subsequent papers provided thorough theoretical basis exploration validity new theory-named by other authors as torsional transduction two-ion theory coupling. Violation several physical laws previous theories have been dealt with considerable detail. In particular he reevaluated extensive literature on hydrolysis provides rigorously argued tri-site involving filled β-catalytic sites during F1/F1-ATPase. Numerous applications proposed throughout his work resulted four substantial dealing re-interpretation Warburg Effect cancer cells trilogy thermodynamics applied to problems comparative physiology, biochemistry ecology. Finally strict mathematical methods opened up approaches validate mechanistic events synthesis/hydrolysis. Here we provide field guide for easy access different aspects this body work.

Language: Английский

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Apoptosis, a Metabolic “Head-to-Head” between Tumor and T Cells: Implications for Immunotherapy

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 924 - 924

Published: May 27, 2024

Induction of apoptosis represents a promising therapeutic approach to drive tumor cells death. However, this poses challenges due the intricate nature cancer biology and mechanisms employed by survive escape immune surveillance. Furthermore, molecules released from apoptotic phagocytes in microenvironment (TME) can facilitate progression evasion. Apoptosis is also pivotal mechanism modulating strength duration anti-tumor T-cell responses. Combined strategies including molecular targeting apoptosis, promoting immunogenic cell death, immunosuppressive cells, affecting energy pathways potentially overcome resistance enhance outcomes. Thus, an effective for within TME should delicately balance selective induction while safeguarding survival, metabolic changes, functionality T crucial involved regulation. Enhancing persistence effectiveness may bolster more resilient enduring response, ultimately advancing outcomes treatment. This review delves into topics multifaceted issue suggests drugs druggable targets possible combined therapies.

Language: Английский

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Symmetry breaking and mismatch in the torsional mechanism of ATP synthesis by FOF1-ATP synthase: mathematical number theory proof and its chemical and biological implications

Theory in Biosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Language: Английский

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Metabolic Risk Factors and Survival in Patients with Glioblastoma

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3666 - 3666

Published: Oct. 30, 2024

Metabolic syndrome increases the risk of developing various systemic cancers. The prevalence metabolic in newly diagnosed glioblastoma patients is unknown. Further, there have been contradictory reports about how affects clinical outcomes. Therefore, purpose this study to test hypothesis that associated with an increased and worsened survival

Language: Английский

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cGAS regulates metabolic reprogramming independently of STING pathway in colorectal cancer

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 443(1), P. 114316 - 114316

Published: Nov. 1, 2024

Language: Английский

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