Biochemistry (Moscow), Journal Year: 2023, Volume and Issue: 88(12-13), P. 2007 - 2022
Published: Dec. 1, 2023
Language: Английский
Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2038)
Published: Jan. 1, 2025
Life has existed on Earth for most of the planet’s history, yet major gaps and unresolved questions remain about how it first arose persisted. Early posed numerous challenges life, including harsh fluctuating environments. Today, many organisms cope with such conditions by entering a reversible state reduced metabolic activity, phenomenon known as dormancy. This process protects inactive individuals minimizes risk extinction preserving information that stabilizes life-system dynamics. Here, we develop framework understanding dormancy early Earth, beginning primer theory its core criteria. We hypothesize dormancy-like mechanisms acting chemical precursors in prebiotic world may have facilitated origin life. Drawing evidence from phylogenetic reconstructions fossil record, demonstrate is prevalent across tree life throughout deep time. These observations lead us to consider might shaped nascent living systems buffering stochastic processes small populations, protecting against large-scale planetary disturbances, aiding dispersal patchy landscapes facilitating adaptive radiations. Given fundamental easily evolved property also likely be feature elsewhere universe.
Language: Английский
Citations
2
The Journal of Cell Biology, Journal Year: 2022, Volume and Issue: 221(11)
Published: Oct. 4, 2022
NBR1 was discovered as an autophagy receptor not long after the first described vertebrate p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while is <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, present already last eukaryotic common ancestor (LECA), appears early Metazoan lineage. Furthermore, yeast-selective receptors Atg19 Atg34 represent homologs. main plants do contain p62, most animal taxa both p62. Mechanistic studies are starting to shed light collaboration between mammalian autophagic degradation of protein aggregates (aggrephagy). Several domains involved cargo recognition, list known substrates for NBR1-mediated increasing. Lastly, roles human diseases such proteinopathies cancer emerging.
Language: Английский
Citations
55
eLife, Journal Year: 2022, Volume and Issue: 11
Published: Nov. 10, 2022
The dichotomy that separates prokaryotic from eukaryotic cells runs deep. transition pro- to eukaryote evolution is poorly understood due a lack of reliable intermediate forms and definitions regarding the nature first host could no longer be considered prokaryote, common ancestor, FECA. last LECA, was complex cell united all traits characterising biology including mitochondrion. role endosymbiotic organelle in this radical towards life is, however, sometimes questioned. In particular discovery asgard archaea has stimulated discussions pre-endosymbiotic complexity Here we review differences similarities among models view as isolated coincidental events archaeal or, on contrary, result response endosymbiosis. Inspecting perspective endosymbiont uncovers can explained having evolved solution housing semi-autonomous why addition another endosymbiont, plastid, added extra compartments. Mitochondria provided selective pressures for origin (and continued maintenance) complexity. Moreover, they also energetic benefit throughout eukaryogenesis evolving thousands gene families unique eukaryotes. Hence, synthesis current data lets us conclude such Golgi apparatus, nucleus, autophagosomes, meiosis sex an imposes.
Language: Английский
Citations
41
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Nov. 17, 2023
Abstract The timing of early cellular evolution, from the divergence Archaea and Bacteria to origin eukaryotes, is poorly constrained. ATP synthase complex thought have originated prior Last Universal Common Ancestor (LUCA) analyses genes, together with ribosomes, played a key role in inferring rooting tree life. We reconstruct evolutionary history synthases using an expanded taxon sampling set develop phylogenetic cross-bracing approach, constraining equivalent speciation nodes be contemporaneous, based on imprint endosymbioses ancient gene duplications. This approach results highly resolved, dated species establishes absolute timeline for evolution. Our show that into F- A/V-type lineages was very event evolution dating back more than 4 Ga, potentially predating diversification Bacteria. cross-braced, life also provides insight recent transitions including eukaryogenesis, showing eukaryotic nuclear mitochondrial diverged their closest archaeal (2.67-2.19 Ga) bacterial (2.58-2.12 relatives at approximately same time, slightly longer stem-lineage.
Language: Английский
Citations
41
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Aug. 16, 2023
Abstract Research in extreme environments has substantially expanded our understanding of the ecology and evolution life on Earth, but a major group organisms been largely overlooked: microbial eukaryotes (i.e., protists). In this Perspective, we summarize data from over 80 studies protists identify focal lineages that are significant interest for further study, including clades within Echinamoebida, Heterolobosea, Radiolaria, Haptophyta, Oomycota, Cryptophyta. We argue prime sampling targets to fill gaps eukaryotic tree increase ecology, metabolism, genome architecture, life.
Language: Английский
Citations
28
ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(10), P. 4028 - 4040
Published: March 1, 2024
Asiaticoside is a triterpenoid in Centella asiatica with wound healing and anti-inflammatory activities. De novo production of asiaticoside remains incompletely resolved. To determine the biosynthetic pathway, variety metabolic engineering modifications were made to achieve high level synthesis asiatic acid Saccharomyces cerevisiae. Transcriptome analysis C. identified 51 glycosyltransferases that are potentially involved glycosylation form asiaticoside. Functional these revealed CaUGT73C7 CaUGT73C8 function glucosylation monoglycoside at C-28 position five rhamnose convert diglucoside de biosynthesis S. cerevisiae, glycoside hydrolase EGH1 degrades was knocked out key pathway enzymes introduced. After series modifications, achieved titer 772.3 μg/L 5 L fermenter. This first time complete has been microorganisms. The results provide valuable reference for other similar saponins.
Language: Английский
Citations
15
Progress in Lipid Research, Journal Year: 2023, Volume and Issue: 91, P. 101237 - 101237
Published: May 25, 2023
Language: Английский
Citations
11
Microbiology and Molecular Biology Reviews, Journal Year: 2023, Volume and Issue: 87(4)
Published: Nov. 29, 2023
SUMMARY In this hypothesis article, we explore the origin of eukaryotic nucleus. doing so, first look afresh at nature defining feature cell and its core functions—emphasizing utility seeing nucleoplasm cytoplasm as distinct regions a common compartment. We then discuss recent progress in understanding evolution from archaeal bacterial ancestors, focusing on phylogenetic experimental data which have revealed that many machines with nuclear activities counterparts. addition, review literature describing biology representatives TACK Asgardarchaeaota - closest known living relatives eukaryotes. Finally, bringing these strands together, propose model for nucleus explains much current data, including predictions can be used to put test.
Language: Английский
Citations
9
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: April 11, 2023
Abstract The timing of early cellular evolution from the divergence Archaea and Bacteria to origin eukaryotes remains poorly constrained. ATP synthase complex is thought have originated prior Last Universal Common Ancestor (LUCA) analyses genes, together with ribosomes, played a key role in inferring rooting tree life. Here we reconstruct evolutionary history synthases using an expanded sampling Archaea, Bacteria, eukaryotes. We developed phylogenetic cross-bracing approach making use endosymbioses ancient gene duplications major subunits infer highly resolved, dated species establish absolute timeline for evolution. Our show that into F- A/V-type lineages, was very event dating back more than 4Ga potentially predating diversification Bacteria. cross-braced, life also provides insight recent transitions including eukaryogenesis, showing eukaryotic nuclear mitochondrial lineages diverged their closest archaeal (2.67-2.19Ga) bacterial (2.58-2.12Ga) relatives at roughly same time, stem being moderately longer.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16169 - 16169
Published: Nov. 10, 2023
The recently observed circadian oscillations of the intestinal microbiota underscore profound nature human-microbiome relationship and its importance for health. Together with discovery clocks in non-photosynthetic gut bacteria rhythms anucleated cells, these findings have indicated possibility that virtually all microorganisms may possess functional biological clocks. However, they also raised many essential questions concerning fundamentals timekeeping, evolution, origin. This narrative review provides a comprehensive overview recent literature molecular chronobiology, aiming to bring together latest evidence on structure mechanisms driving microbial while pointing potential applications this knowledge medicine. Moreover, it discusses hypotheses regarding evolution timing describes functions peroxiredoxins cells their contribution cellular clockwork. diversity among various human-associated role transcriptional post-translational timekeeping are addressed. Finally, metabolic oscillators host-microbiome communication is presented.
Language: Английский
Citations
4