Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes DOI Open Access
María Luisa Moreno-Cortés, Enrique Meza, Jaime García‐Mena

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 616 - 616

Published: Feb. 23, 2024

The desynchronization of physiological and behavioral mechanisms influences the gut microbiota eating behavior in mammals, as shown both rodents humans, leading to development pathologies such Type 2 diabetes (T2D), obesity, metabolic syndrome. Recent studies propose resynchronization a key input controlling cycles contributing reducing risk suffering some chronic diseases diabetes, or In this analytical review, we present an overview how its implications for microbiome make people vulnerable intestinal dysbiosis consequent diseases. particular, explore eubiosis–dysbiosis phenomenon and, finally, topics aimed at addressing chronotherapy strategy prevention

Language: Английский

The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support DOI Open Access

Monika Sejbuk,

Adam Siebieszuk,

Anna Maria Witkowska

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2259 - 2259

Published: July 13, 2024

Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep overall health. This review explores role of gut microbiota in regulating through such as short-chain tryptophan, serotonin, melatonin, gamma-aminobutyric acid. A balanced diet rich plant-based foods enhances production these sleep-regulating metabolites, potentially benefiting aims investigate how habits composition, it produces, subsequent impact on related health conditions.

Language: Английский

Citations

9
Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer DOI Open Access

Abdo Jurjus,

Jad El Masri, Maya Ghazi

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1236 - 1236

Published: April 21, 2024

Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly associated with immune system dysregulation and dysbiosis, leading to inflammation in the gastrointestinal tract (GIT) multiple extraintestinal manifestations. The pathogenesis IBD not completely elucidated. However, it an increased risk colorectal cancer (CRC), which one most common malignancies. In both CRC, complex interplay occurs between gut microbiota (GM), alteration GM composition. Melatonin, neuroendocrine hormone, was found be involved this interplay, especially since present high amounts gut, some protective effects. Actually, melatonin enhances integrity intestinal mucosal barrier, regulates response, alleviates inflammation, attenuates oxidative stress. Thereby, authors summarize multifactorial interaction focusing on new findings related mechanisms action addition its documented positive outcomes treatment these two pathologies possible future perspectives use as adjuvant therapy.

Language: Английский

Citations

4
Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea DOI

R.R Hicks,

David Gozal, Sadia Ahmed

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106493 - 106493

Published: April 1, 2025

Language: Английский

Citations

0
Comprehensive integrative analysis of circadian rhythms in human saliva DOI Creative Commons
Nina Nelson, Deeksha Malhan, Janina Hesse

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: May 10, 2025

Abstract The circadian clock orchestrates vital physiological functions, with its dysregulation implicated in various pathologies. Assessing human status via the measurement of rhythms is crucial for health management and disease treatment. Saliva provides a non-invasive means such analysis. In this study, we examined related parameters 21 healthy individuals ( n = 4 – 19 per experiment), assessing different data types, including saliva gene expression our TimeTeller ® methodology, hormone levels, cell composition, self-assessment tests chronotype evaluation. While substantial individual variability profiles was observed, found significant correlations between acrophases ARNTL1 cortisol, both correlated bedtime on sampling day. Our findings validate robustness reliability method determining peripheral humans, offering potential clinical applications diverse cohorts.

Language: Английский

Citations

0
Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes DOI Open Access
María Luisa Moreno-Cortés, Enrique Meza, Jaime García‐Mena

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 616 - 616

Published: Feb. 23, 2024

The desynchronization of physiological and behavioral mechanisms influences the gut microbiota eating behavior in mammals, as shown both rodents humans, leading to development pathologies such Type 2 diabetes (T2D), obesity, metabolic syndrome. Recent studies propose resynchronization a key input controlling cycles contributing reducing risk suffering some chronic diseases diabetes, or In this analytical review, we present an overview how its implications for microbiome make people vulnerable intestinal dysbiosis consequent diseases. particular, explore eubiosis–dysbiosis phenomenon and, finally, topics aimed at addressing chronotherapy strategy prevention

Language: Английский

Citations

2