Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 15, 2024

Normal life requires cell division to produce new cells, but death is necessary maintain balance. Dysregulation of can lead the survival and proliferation abnormal promoting tumor development. Unlike apoptosis, necrosis, autophagy, newly recognized forms regulated (RCD) cuproptosis, ferroptosis, PANoptosis provide novel therapeutic strategies for treatment. Increasing research indicates that immune cells mediated by these discovered regulate microenvironment (TME) influence effectiveness immunotherapy. This review primarily elucidates molecular mechanisms their complex effects on TME. also summarizes exploration nanoparticle applications in therapy based vivo vitro evidence derived from induction or inhibition RCD pathways.

Language: Английский

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Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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PANoptosis: Mechanism and Role in Pulmonary Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15343 - 15343

Published: Oct. 19, 2023

PANoptosis is a newly defined programmed cell death (PCD) triggered by series of stimuli, and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) concomitantly. Normally, recognized as strategy to eliminate unnecessary cells, inhibit the proliferation invaded pathogens maintain homeostasis; however, vigorous can cause excessive inflammation tissue damage. Acute lung injury (ALI) chronic obstructive pulmonary syndrome (COPD) exacerbation related several (e.g., influenza A virus, SARS-CoV-2) known PANoptosis. An understanding mechanism specific regulators may help address pathological systems these diseases. This review presents our potential role in different

Language: Английский

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Cell death shapes cancer immunity: spotlighting PANoptosis

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: June 15, 2024

Abstract PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements pyroptosis, apoptosis, and necroptosis. is governed by newly discovered cytoplasmic multimeric protein complex known as the PANoptosome. Unlike each these PCD types individually, still in early stages research warrants further exploration its specific regulatory mechanisms primary targets. In this review, we provide brief overview conceptual framework molecular components PANoptosis. addition, highlight recent advances understanding therapeutic applications By elucidating crosstalk between apoptosis necroptosis summarizing functional consequences special focus on tumor immune microenvironment, review aims to theoretical basis for potential application cancer therapy.

Language: Английский

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PANoptosis in cancer, the triangle of cell death

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(24), P. 22206 - 22223

Published: Dec. 1, 2023

Abstract Background PANoptosis is a novel form of programmed cell death (PCD) found in 2019 that regulated by the PANoptosome. combines essential features pyroptosis, apoptosis, and necroptosis, forming “death triangle” cells. While necroptosis have been extensively studied for their roles human inflammatory diseases many other clinical conditions, historically they were considered as independent processes. However, emerging evidence indicates these PCDs exhibit cross talk interactions, resulting development concept PANoptosis. Methods In this review, we offer concise summary fundamental mechanisms necroptosis. We subsequently introduce notion detail assembly mechanism PANoptosome complex which responsible inducing death. also describe some regulatory networks Results now has associated with various including cancer. Although exact function each tumor not fully understood, it represents prospective avenue cancer therapy, offering promise advancements therapy. Conclusions future, in‐depth study will continue to help us understanding processes underlying provide scientific support research.

Language: Английский

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VISH-Pred: an ensemble of fine-tuned ESM models for protein toxicity prediction

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 25(4)

Published: May 23, 2024

Abstract Peptide- and protein-based therapeutics are becoming a promising treatment regimen for myriad diseases. Toxicity of proteins is the primary hurdle therapies. Thus, there an urgent need accurate in silico methods determining toxic to filter pool potential candidates. At same time, it imperative precisely identify non-toxic expand possibilities biologics. To address this challenge, we proposed ensemble framework, called VISH-Pred, comprising models built by fine-tuning ESM2 transformer on large, experimentally validated, curated dataset protein peptide toxicities. The steps VISH-Pred framework efficiently estimate toxicities taking just sequence as input, employing under sampling technique handle humongous class-imbalance data learning representations from fine-tuned language which then fed machine techniques such Lightgbm XGBoost. able correctly both peptides/proteins with toxicity proteins, achieving Matthews correlation coefficient 0.737, 0.716 0.322 F1-score 0.759, 0.696 0.713 three non-redundant blind tests, respectively, outperforming other over $10\%$ these quality metrics. Moreover, achieved best accuracy area receiver operating curve scores independent test sets, highlighting robustness generalization capability framework. By making available easy-to-use web server, expect serve valuable asset future endeavors aimed at discerning peptides enabling efficient therapeutics.

Language: Английский

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PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.

Language: Английский

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Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(4), P. 167737 - 167737

Published: Feb. 17, 2025

Language: Английский

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Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 24, 2025

This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, emerging areas for future research. A bibliometric approach was applied 2677 publications retrieved from Web Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, bibliometrix-were employed visualize co-citation networks, detect citation bursts, map collaborative patterns among authors, institutions, countries. Inclusion criteria focused on articles reviews that addressed conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways. Publication outputs grew markedly, reflecting a shift early investigations basic apoptotic mechanisms broader explorations ferroptosis. China led publication volume citations, driven by substantial governmental funding large clinical cohorts. The United States Japan also contributed significantly, forming international research networks spanned Asia Europe. Leading particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters Reports were prominent outlets new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, gene-editing strategies. Keyword analyses revealed ascendance immuno-oncology, network pharmacology, translational applications targeting multiple regulated Bibliometric evidence underscores rapid expansion multidisciplinary integrates diverse pathways cancer. Continued leveraging advanced genomics immunologic strategies, are poised accelerate breakthroughs enable more personalized, effective therapies.

Language: Английский

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Caspases in PANoptosis

Current Research in Translational Medicine, Journal Year: 2025, Volume and Issue: 73(1), P. 103502 - 103502

Published: Jan. 1, 2025

Language: Английский

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