Surgical Clinics of North America, Journal Year: 2024, Volume and Issue: 105(2), P. 301 - 311
Published: Nov. 5, 2024
Language: Английский
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 7, 2025
The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for loads in the diagnosis and outcome prediction infection, particularly cases primary lymphoproliferative diseases inflammatory bowel disease (IBD). Receiver operating characteristic (ROC) curves were examined determine suitable thresholds diagnosing predicting its prognosis. 108 patients retrospectively assigned test group, while 56 included validation group. Plasma significantly higher group compared non-intestinal (Median: 2.02 × 102 copies/mL, interquartile range [IQR]: 5.49 101-6.34×103 copies/mL versus 4.2×101 IQR: 1.07 ×101-6.08×101 copies/mL; P < 0.0001). at 9.21×101 6.77×101 proved beneficial identification prognostication respectively. Values 0.82 0.71 yielded by area under ROC curve (AUC) cohort, corresponding sensitivities 84.38% (95% confidence interval [95%CI]: 68.25%-93.14%) 87.5% (95%CI: 69%-95.66%), specificities 83.33% 64.15%-93.32%) 68.09% 53.83%-79.6%), positive predictive values (PPV) 87.1% 71.15%-94.87%) 58.33% 42.2%-72.86%), likelihood ratios (LR+) 5.06 2.74 Furthermore, 5.4×102 helped differentiate IBD with from EBV-positive disorders (PIEBV+LPDs), achieving an AUC 0.85 within well 85% sensitivity 63.96%-94.76%), 91.67% specificity 64.61%-99.57%), 94.44% PPV 74.24%-99.72%), LR+ 10.2 cohort. demonstrates notable potential distinguishing between different patient cohorts although requires further optimization clinical application.
Language: Английский
Citations
3
Precision Clinical Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Epstein-Barr virus (EBV) infection is associated with clinical symptoms, treatment response, need for surgical intervention, and an enhanced likelihood of lymphoma among patients ulcerative colitis (UC). However, existing studies have primarily concentrated on the epidemiological associations between EBV UC, leaving mechanisms by which exacerbates poorly understood. Clinical specimens UC a mouse model dextran sulfate sodium-induced concurrent murine γ-herpesvirus 68 (MHV-68) were utilized to investigate relationship macrophage pyroptosis. In vivo, adoptive transfer MHV-68-induced macrophages depletion performed elucidate underlying mechanisms. vitro, myeloid leukemia mononuclear cells human (THP-1) derived from bone marrow (BMDMs) stimulated MHV-68, respectively, assess pyroptosis glycolysis. EBV-induced activation was positively correlated disease activity in patients. Furthermore, MHV-68 activated upregulating gasdermin D, NLRP3, interleukin-1β, interleukin-18 colonic tissues peritoneal mice colitis. also mediated THP-1 BMDMs, respectively. Additionally, BMDMs aggravated colitis, whereas attenuated intestinal injury. Mechanistically, promoted glycolysis, while glycolysis inhibitor, 2-deoxy-D-glucose, blocked this process vitro. driving through upregulation indicating potential therapeutic approach mitigate inflammation.
Language: Английский
Citations
2
Healthcare, Journal Year: 2025, Volume and Issue: 13(2), P. 128 - 128
Published: Jan. 11, 2025
Background/Objectives: Our study describes hyperbaric oxygen therapy (HBOT) as an additional in the conservative treatment of Crohn’s disease (CD) and its benefit early postoperative period to prevent surgical complications improve gastrointestinal motility. Methods: This retrospective evaluated HBOT patients hospitalized at Clinical Hospital Center Split for CD between 2015 2020. Patients (N = 61) aged 19 67 with perianal fistulas, abscesses, obstruction, stenosis, or bleeding were included, excluding those ulcerative colitis requiring intensive care. retrospectively divided into conservatively surgically treated groups, was administered over 15–25 days, lasting 60 min 2.2 absolute atmospheres (ATA). We analyzed outcomes HBOT-treated groups compared a cohort from preceding five years who did not receive HBOT. Results: 61 HBOT, including 34 27 patients. significantly reduced activity indices (311.7 ± 59.1 vs. 114 29.8; 203.6 24.1 83.8 15, patients, 352.8 45.7 109 22.8; 270.4 19.7 140.3 10.6 patients) accelerated bowel peristalsis recovery, 94.1% achieving remission. Comparison historical showed faster recovery improved group. Conclusions: is useful postponing avoiding treatment, operated it improves reduces rate complications.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 24, 2024
The introduction of anti-tumor necrosis factor α (TNFα) biologics significantly innovated inflammatory bowel disease (IBD) treatment and increased medical costs. recent expiration patents some anti-TNFα (such as infliximab adalimumab) facilitated the development biosimilars. Comparable pharmacokinetic, efficacy, safety, immunogenicity profiles between originators biosimilars were demonstrated in different studies. Anti-TNFα hold promise for reducing high cost increasing patient access to biologics. In this review, we outline current data on use patients with IBD, a focus adalimumab potential benefits, challenges, future directions are also discussed review.
Language: Английский
Citations
4
Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(3), P. 427 - 434
Published: April 17, 2025
Cardiovascular diseases remain the leading cause of death worldwide, underscoring urgent need for additional therapeutic strategies to reduce their mortality rates. This review systematically outlines historical development and recent advances hyperbaric oxygen therapy in cardiovascular diseases, with a focus on its mechanisms clinical outcomes. Hyperbaric enhances delivery ischemic reperfused tissues, promotes angiogenesis, significantly suppresses oxidative stress, inflammatory cascades, cardiomyocyte apoptosis, demonstrating multifaceted potential conditions. Specifically, combined reperfusion has been shown markedly improve left ventricular ejection fraction acute myocardial infarction. In heart failure, it facilitates repair cardiac function. For arrhythmias, effectively reduces frequency duration premature contractions paroxysmal tachycardia, while mitigating risk neurological complications following atrial fibrillation ablation. Furthermore, preconditioning surgery demonstrated improvements stroke work, reductions postoperative injury, decrease related complications. Despite promising applications, widespread adoption remains hindered by lack standardized treatment protocols high-quality evidence from rigorous trials. conclusion, this underscores value domain highlighting further optimization parameters exploration synergistic effects conventional therapies provide clearer guidance implementation.
Language: Английский
Citations
0
Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 548 - 549
Published: April 29, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 7, 2024
The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs). Central to this process is hypoxia-inducible factor-1 (HIF-1), which orchestrates wide array cellular responses under low conditions. This review delves into multifaceted roles microenvironment modulating immune cell function, particularly highlighting its impact on activation, metabolic reprogramming, angiogenesis. Specific focus given mechanisms hypoxia contributes development exacerbation such rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), dermatomyositis (DM). In these conditions, not only disrupts tolerance but also enhances inflammatory promotes tissue damage. discusses emerging therapeutic strategies aimed at targeting pathways, including application HIF-1α inhibitors, mTOR other modulators response. By providing comprehensive overview interplay between dysfunction AIDs, offers new perspectives underlying highlights potential avenues for intervention.
Language: Английский
Citations
3
Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(12), P. 408 - 408
Published: Dec. 19, 2024
Maintaining the physiological function of vascular endothelium and endothelial glycocalyx is crucial for prevention cardiovascular disease, which one leading causes morbidity mortality worldwide. Damage to these structures can lead atherosclerosis, hypertension, other problems, especially in individuals with risk factors such as diabetes obesity. Endothelial dysfunction associated ischemic disease has a negative impact on overall health. The aim this review was comprehensively summarize role health thrombo-inflammatory conditions. It highlights how dysfunction, influenced by diabetes, chronic kidney obesity, leads adverse outcomes, including heart failure. Recent evidence suggests that hyperbaric oxygen therapy (HBOT) may offer therapeutic benefits treatment disease. This presents current mechanisms HBOT promotes angiogenesis, shows antimicrobial immunomodulatory effects, enhances antioxidant defenses, stimulates stem cell activity. latest findings important topics will be presented, effects cardiac function, plaque stability, integrity. In addition, alleviating aging, glucose metabolism regulation discussed, along its inflammation potential benefit ischemia–reperfusion injury. While demonstrates significant potential, also addresses risks excessive oxidative stress toxicity. By combining information molecular maintenance homeostasis, provides valuable insights into development innovative strategies aimed at protecting restoring prevent treat diseases.
Language: Английский
Citations
3
Revista Española de Enfermedades Digestivas, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
I read with great interest the letter by Calderón et al., who clearly described effectiveness of hyperbaric oxygen therapy (HBOT) for refractory ischemic ulcer at ileorectal anastomosis in Crohn's disease (CD). congratulate them on their efforts achieving a favorable long-term outcome. would like to share my experience HBOT perianal CD (PCD). In addition, discuss recent trials PCD.
Language: Английский
Citations
0
Revista ORL, Journal Year: 2024, Volume and Issue: unknown, P. e31966 - e31966
Published: June 15, 2024
Introducción: La pérdida auditiva neurosensorial súbita es un grave problema de salud social en las sociedades modernas. Aunque la tasa mortalidad directa muy baja, su influencia calidad vida enorme; por eso que implementación terapias más efectivas y seguras para el paciente crucial minimizar riesgo complicaciones reacciones adversas al tratamiento. Los esteroides constituyen base del tratamiento, sin embargo, recientemente se ha propuesto uso oxigenoterapia hiperbárica estos pacientes. Objetivo: Realizar una revisión sistemática sobre eficacia como adyuvante repentina. Método: Se seleccionaron ensayos clínicos aleatorizados controlados, realizados humanos, llevados a cabo los últimos diez años. principal datos usada sido PubMed, través plataforma National Library of Medicine. Resultados: eficaz tratamiento muestra total fue 806 pacientes ocho clínicos. frecuencia aplicación vez día, durante 28 90 minutos sesión, con número sesiones entre 10 20. Conclusiones: mejora umbrales auditivos conduce mejor recuperación farmacológico estándar sí solo
Citations
0