bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 3, 2023
Summary
Intraepithelial
lymphocytes
expressing
the
γδ
T
cell
receptor
(γδ
IELs)
provide
immunosurveillance
of
intestinal
barrier.
Interestingly,
IEL
number
is
reduced
in
patients
with
active
Crohn’s
disease
(CD).
Here,
we
report
an
underappreciated
role
for
IELs
maintaining
mucosal
tolerance
during
onset
and
progression
CD-like
ileitis
using
TNF
ΔARE/+
mouse
model.
Decreased
epithelial
HNF4G/BTNL
expression
followed
by
a
loss
ileal
impaired
barrier
surveillance
prior
to
histological
disease.
A
reduction
immunoregulatory
CD39
+
coincides
influx
immature,
peripheral
-
cells
into
epithelium
leading
expansion
induced
IELs,
while
earlier
depletion
correlates
accelerated
inflammation.
Our
findings
identify
multiple
layers
dysregulation
development
indicating
that
tissue-resident
may
contribute
initiation
CD.
Journal of Autoimmunity,
Journal Year:
2023,
Volume and Issue:
141, P. 103114 - 103114
Published: Sept. 23, 2023
The
gastrointestinal
tract
is
home
to
the
largest
microbial
population
in
human
body.
gut
microbiota
plays
significant
roles
development
of
immune
system
and
has
a
substantial
impact
on
maintenance
tolerance
beginning
early
life.
These
microbes
interact
with
dynamic
interdependent
manner.
They
generate
signals
by
presenting
vast
repertoire
antigenic
determinants
metabolites
that
influence
development,
maturation
immunological
function
homeostasis.
At
same
time,
both
innate
adaptive
systems
are
involved
modulating
stable
ecosystem
between
commensal
pathogenic
microorganisms.
Hence,
host
work
together
maintain
homeostasis
synergistically.
In
susceptible
hosts,
disruption
such
harmonious
state
can
greatly
affect
health
lead
various
auto-inflammatory
autoimmune
disorders.
this
review,
we
discuss
our
current
understanding
interactions
immunity
an
emphasis
on:
a)
important
players
immunity;
b)
contribution
metabolites;
c)
effect
as
well
alteration
microbiome
molecular
mechanisms
driving
autoimmunity
diseases.
Protein & Cell,
Journal Year:
2023,
Volume and Issue:
14(10), P. 709 - 712
Published: May 23, 2023
With
its
critical
role
in
human
health
and
disease,
the
microbiome
has
transformed
modern
biology.
Over
past
few
years,
research
evolved
rapidly,
with
microbiologists
gradually
shifting
their
focus
from
cataloging
microorganisms
to
understanding
functional
roles
how
they
interact
host.
Here,
we
present
global
trends
summarize
current
work
on
published
Protein
&
Cell.
In
closing,
highlight
some
of
major
advancements
research,
including
technical,
practical,
conceptual
advancements,
that
aim
enhance
disease
diagnosis,
medicine
development,
personalized
interventions
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(10)
Published: Oct. 1, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
inflammatory
disorder
of
the
gastrointestinal
tract,
but
molecular
mechanisms
underlying
IBD
are
incompletely
understood.
In
this
study,
we
explored
role
and
regulating
mechanism
otubain
2
(OTUB2),
deubiquitinating
enzyme,
in
IBD.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(4), P. 447 - 447
Published: April 6, 2024
Krill
oil
is
extracted
from
krill,
a
small
crustacean
in
the
Antarctic
Ocean.
It
has
received
growing
attention
because
of
krill
oil’s
unique
properties
and
diverse
health
benefits.
Recent
experimental
clinical
studies
suggest
that
it
potential
therapeutic
benefits
preventing
development
range
chronic
conditions,
including
inflammatory
bowel
disease
(IBD).
enriched
with
long-chain
n-3
polyunsaturated
fatty
acids,
especially
eicosapentaenoic
docosahexaenoic
potent
antioxidant
astaxanthin,
contributing
to
its
properties.
The
possible
underlying
mechanisms
include
anti-inflammatory
actions,
maintaining
intestinal
barrier
functions,
modulating
gut
microbiota.
This
review
aims
provide
an
overview
beneficial
effects
bioactive
components
on
inflammation
discuss
findings
molecular
associated
role
IBD
prevention
treatment.
Foods,
Journal Year:
2024,
Volume and Issue:
13(13), P. 2157 - 2157
Published: July 8, 2024
The
gut
has
been
a
focus
of
chronic
disease
research.
microbiota
produces
metabolites
that
act
as
signaling
molecules
and
substrates,
closely
influencing
host
health.
Nondigestible
oligosaccharides
(NDOs),
common
dietary
fiber,
play
an
important
role
in
regulating
the
structure
function
microbiota.
Their
mechanism
action
is
mainly
attributed
to
providing
carbon
source
specific
probiotics,
producing
related
metabolites,
microbial
community.
However,
due
selective
utilization
oligosaccharides,
some
factors,
such
type
have
different
impacts
on
composition
populations
production
colon
ecosystem.
This
review
systematically
describes
key
factors
by
microorganisms
elaborates
how
affect
host’s
immune
system,
inflammation
levels,
energy
metabolism
diversity
metabolic
function,
which
turn
affects
onset
progress
diseases,
especially
diabetes,
obesity,
depression,
intestinal
inflammatory
constipation.
In
this
review,
we
re-examine
interaction
mechanisms
between
its
associated
explore
new
strategies
for
promoting
human
health
combating
diseases
through
interventions.
