Recent progress of nanomedicine in managing dry eye disease

Advances in Ophthalmology Practice and Research, Journal Year: 2024, Volume and Issue: 4(1), P. 23 - 31

Published: Jan. 29, 2024

Dry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5 % to 50 %, impacting substantial proportion individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for diseases, it suffers drawbacks such as low bioavailability, rapid metabolism, and frequent requirements. Fortunately, advancements nanomedicine offer effective solutions address aforementioned issues provide assistance treatment DED. considered multifactorial surface tear film, which integrity film function structure plays crucial role maintaining homeostasis surface. conventional involves utilization artificial products, cyclosporin, corticosteroids, mucin secretagogues, nonsteroidal anti-inflammatory drugs. Furthermore, presently field study, numerous clinical trials underway various nanotherapeutics including nanoemulsions, nanosuspensions, liposomes, micelles. Notably, some these innovative nanoformulations have already received FDA approval novel remedies DED, advancement poised enhanced prospects solve shortcomings existing treatments partially. This article provides an overview latest treatment, while expected witness remarkable breakthrough shortly development nanomedicine, bringing promising patients suffering conditions.

Language: Английский

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Engineering Ultra‐Small Cerium‐Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(6)

Published: Dec. 6, 2023

Abstract Dry eye disease (DED) is a widespread ophthalmic illness that inflicts massive economic and medical burdens on society. Although oxidative stress closely associated with the onset of DED, barely any quantities antioxidants are clinically available owing to low efficiency, toxicity, poor bioavailability. Cerium‐based nanozymes possess promising enzyme‐mimetic activities in scavenging reactive oxygen species (ROS). Moreover, ultra‐small metal–organic frameworks (MOFs) have potential for more efficient drug delivery, ROS elimination, therapeutic efficacy. However, development cerium‐based MOFs (Ce‐MOFs) limited small minority due challenges synthetic process stability. By simply adjusting raw ingredients concentrations, three types Ce‐MOFs distinct particle sizes synthesized: Ce‐MOF 1 (213 nm), 2 (36 3 (2 nm). In comparison, obtained exhibited superior antioxidant capacity, decreased cytotoxicity, excellent ocular penetration. Therapeutically, demonstrated be highly alleviating DED by suppressing inflammation, boosting corneal epithelial repair, facilitating tear secretion recovery. The novel may serve as alternative treatment other ROS‐related disorders when combined biocompatibility.

Language: Английский

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Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 669 - 669

Published: April 12, 2024

Dry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used treat DED; however, reports indicate that only a minor proportion of drug bioavailability achieved by majority drops available on market. In this context, enhancing ability overcome ocular barriers and prolonging its residence time surface represent new challenge in field carrier systems. Therefore, research has focused development multi-functional nanosystems, such as nanoemulsions, liposomes, dendrimers, hydrogels, other nanosized carriers. These systems designed improve efficacy and, at same time, require fewer daily administrations, with potentially reduced side effects. This review summarizes different nanotechnologies developed, their role DED, nanotechnology-based eyedrops currently approved for DED treatment.

Language: Английский

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Nanozymes for Treating Ocular Diseases

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.

Language: Английский

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Multifunctional nanogel loaded with cerium oxide nanozyme and CX3CL1 protein: Targeted immunomodulation and retinal protection in uveitis rat model

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122617 - 122617

Published: May 17, 2024

Language: Английский

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A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract Immune checkpoint blockade therapy provides a new strategy for tumor treatment; however, the insufficient infiltration of cytotoxic T cells and immunosuppression in microenvironment lead to unsatisfied effects. Herein, we reported lipid/PLGA nanocomplex (RDCM) co-loaded with photosensitizer Ce6 indoleamine 2,3-dioxygenase (IDO) inhibitor 1MT improve immunotherapy colon cancer. Arginine–glycine–aspartic acid (RGD) as targeting moiety was conjugated on 1,2-distearoyl-snglycero-3-phosphoethanolamine lipid via polyethylene glycol (PEG), programmed cell death-ligand 1 (PD-L1) peptide DPPA (sequence: CPLGVRGK-GGG-d(NYSKPTDRQYHF)) immobilized terminal group PEG matrix metalloproteinase 2 sensitive linker. The were encapsulated PLGA nanoparticles. drug loaded nanoparticles composited RGD modified lecithin form nanocomplexes. When nanocomplexes delivered tumor, released by cleavage 2-sensitive linker PD-L1 binding. facilitated cellular internalization avβ3 integrin. Strong immunogenic death induced 1O2 generated from irradiation under 660 nm laser. inhibited activity IDO reduced inhibition caused kynurenine accumulation microenvironment. RDCM maturation dendritic cells, IDO, markedly recruited proportion tumor-infiltrating CT26 tumor-bearing mice, triggering robust immunological memory effect, thus effectively preventing metastasis. results indicated that dual effects is promising platform targeted photoimmunotherapy

Language: Английский

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Tailoring metal oxide nanozymes for biomedical applications: trends, limitations, and perceptions

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(27), P. 5965 - 5984

Published: July 16, 2024

Language: Английский

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A Cerium Oxide Loaded Hyaluronic Acid Nanosystem Remits Glucose Oxidative Stress-Induced Odontoblasts Mitochondrial Apoptosis through Regulation of PGAM5 Pathway

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Diabetes mellitus (DM) induced mitochondrial oxidative stress (OS) can lead to severe injury of dental pulp. The cerium oxide nanoparticles (CNP) have been proven excellent antioxidative activity. However, whether CNP relieve pulp damage caused by DM and the underlying mechanisms remain unclear. In this study, we modified ceria with hyaluronic acid prepare nanoceria good biocompatibility, water solubility, stability, namely, HACNP (hyaluronic nanoparticles). We demonstrated protective effect on diabetic OS-induced apoptosis in pulp-like cells. As far as mechanism action was concerned, glucose oxidase (GO) treatment promoted activation phosphoglycerate mutase family 5 (PGAM5) leading abnormalities an odontoblast-like cell line (mDPC6T). Knockdown or overexpression PGAM5 further validate these results. Meanwhile, remitted GO-related toxicity via down-regulating expression, whereas abolished beneficial HACNP. Furthermore, constructed animal research model injury, also confirmed that alleviated decreased expression level tissue. conclusion, results revealed played a role diabetes-associated through targeting PGAM5-mediated pathway, providing idea method for prevention diabetes-induced damage.

Language: Английский

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A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti‐Inflammatory Effects in the Treatment of Dry Eye Disease

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), critical factor perpetuating inflammatory cycle in DED. Effectively scavenging ROS essential to impede progression In this study, boronophenylalanine‐ containing polydopamine (PDA‐PBA) nanoparticles are developed loaded with melatonin (MT), which blended poly(vinyl alcohol) (PVA) create drops PVA/ PDA‐PBA@MT (PPP@MT). vitro vivo studies demonstrate PPP@MT exhibits dual functionalities reducing production downregulating pathways, thereby preserving mitochondrial integrity further inhibiting programmed cell death. Following treatment, tear secretion, corneal structure, number goblet cells markedly restored mouse model dry eye, indicating therapeutic efficacy agent. Collectively, PPP@MT, characterized minimal side effects favorable bioavailability, offers promising insights for management DED other ROS‐mediated disorders.

Language: Английский

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Catalytic activity nanozymes for microbial detection

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216578 - 216578

Published: March 4, 2025

Language: Английский

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