International Journal of Biology Pharmacy and Allied Sciences,
Journal Year:
2023,
Volume and Issue:
12(10 (SPECIAL ISSUE))
Published: Oct. 12, 2023
This
systematic
review
highlights
the
potential
of
antioxidants
as
therapeutic
intervention
in
dry
eye
disease.Preclinical
reports
assessing
effect
plant
based
and
synthetic
against
disease
was
collected
from
online
electronic
databases
like
Scopus,
PubMed,
Science
direct,
DOAJ,
Jgate.The
protocol
registered
on
PROSPERO,
registration
no.CRD42023420934.The
followed
PRISMA
approach
for
including
all
were
appraised
risk
bias
using
SYRCLE's
RoB
tool.From
search
results
26
articles
met
inclusion
criteria
review.These
analyzed
rodent
species
strain
used,
which
improved
tear
volume,
restore
conjunctival
goblet
cells,
amelioration
inflammatory
cytokines
TNF-α,
IL-1β,
NLRP3
reduction
oxidative
stress.The
studies
reported
this
insinuates
target
their
mechanism
action
stress,
corneal
irregularity,
ocular
surface
inflammation
apoptosis
secretion.These
repots
compositely
suggest
that
can
ameliorate
negative
effects
improve
secretion
to
maintain
homeostasis.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Proliferative
vitreoretinopathy
(PVR)
is
a
common
cause
of
vision
loss
after
retinal
reattachment
surgery
and
ocular
trauma.
The
key
pathogenic
mechanisms
PVR
development
include
the
proliferation,
migration
epithelial-mesenchymal
transition
(EMT)
pigment
epithelial
cells
(RPEs)
activated
by
growth
factors
cytokines
surgery.
Although
some
drugs
have
been
tried
in
treatments
as
basic
investigations,
limited
efficacy
remains
an
obstacle,
which
may
be
due
to
single
pharmacological
action
lack
targeting.
Herein,
anti-proliferative
Daunorubicin
anti-inflammatory
Dexamethasone
were
co-loaded
RPEs-derived
exosomes
(Exos),
obtaining
Exos-based
dual
drug-loaded
nanocarrier
(Exos@D-D),
used
for
multiple
therapy.
Owing
advantages
homologous
Exos
drug
loading,
Exos@D-D
showed
good
RPEs
targeting
well
improved
uptake
efficiency,
could
inhibit
migration,
EMT
effectively.
animal
studies
also
demonstrated
that
effectively
inhibits
production
proliferative
membranes
prevents
further
inflammation,
shows
significant
therapeutic
effects
on
biocompatibility.
Such
investigation
not
only
provides
promising
approach
multifunctional
exosome
delivery
systems
construction,
but
has
great
potential
clinical
therapy
application.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(16), P. 3732 - 3732
Published: Aug. 7, 2024
Dry
eye
syndrome
(DES)
is
a
dynamic,
chronic
disease
of
the
ocular
surface
and
appendages
caused
by
inflammation.
The
most
common
symptoms
include
redness,
itching,
blurred
vision,
resulting
from
dysfunction
meibomian
glands
impaired
tear-film
production.
Factors
contributing
to
development
DES
environmental
elements,
such
as
UV
radiation,
internal
hormonal
imbalances.
These
factors
increase
oxidative
stress,
which
exacerbates
inflammation
on
accelerates
DES.
In
recent
years,
incidence
has
risen,
leading
greater
need
develop
effective
treatments.
Current
treatments
for
dry
are
limited
primarily
focus
alleviating
individual
symptoms,
reducing
surface.
However,
it
crucial
understand
pathomechanism
tailor
treatment
address
underlying
causes
achieve
best
possible
therapeutic
outcomes.
Therefore,
in
this
review,
we
analyzed
impact
stress
gain
better
understanding
its
examined
recently
developed
nanosystems
that
allow
drugs
be
delivered
directly
site.
Indian Journal of Science and Technology,
Journal Year:
2024,
Volume and Issue:
17(13), P. 1331 - 1339
Published: March 25, 2024
Objective:
Here,
we
synthesize
cerium
oxide
nanoparticles,
successfully
characterize
them,
and
study
the
interaction
between
enzymes
nanoparticles
(CeO2
NPs)
using
a
simple
optical
spectroscopic
technique.
Method:
CeO2
was
fabricated
by
chemical
method.
Characterizations
were
done
UV-Vis
absorption
spectra,
FESEM
images,
XRD
data.
For
biomolecular
study,
papain
used
as
model
enzyme.
Two
different
concentrations
of
CeO2,
namely
small
concentration
range
(0.05810
to
0.40670
mM)
large
(0.58100
0.92961
mM),
taken
with
papain.
spectra
recorded
bioconjugate
formation.
Findings:
The
NPs
have
an
intense
peak
at
352
nm
band
gap
3.78
eV.
pattern
showed
unit
cell
is
cubic
average
particle
size
41.36
nm.
binding
resulted
in
red
shift
its
peak.
apparent
association
constant
(Kapp)
calculated
for
found
be
0.747
×
103
M-1
0.278
concentrations.
In
concentrations,
aggregation
occurs
instead
corona
Novelty:
To
best
our
knowledge,
this
may
first
enzyme
NPs.
This
contributes
application
field
biomedicine.
Keywords:
Cerium
oxide,
Papaya
proteinase
(PP),
Absorption
Bioconjugate,
Association
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(27), P. 34757 - 34771
Published: July 1, 2024
Dry
eye
disease
(DED)
is
a
chronic
multifactorial
ocular
surface
mainly
caused
by
the
instability
of
tear
film,
characterized
series
discomforts
and
even
visual
disorders.
Oxidative
stress
has
been
recognized
as
an
upstream
factor
in
DED
development.
Diquafosol
sodium
(DQS)
agonist
P2Y2
receptor
to
restore
integrity/stability
film.
With
ability
alternate
between
Ce3+
Ce4+,
cerium
oxide
nanozymes
could
scavenge
overexpressed
reactive
oxygen
species
(ROS).
Hence,
DQS-loaded
nanozyme
was
designed
boost
synergistic
treatment
DED.
Cerium
with
branched
polyethylenimine-graft-poly(ethylene
glycol)
nucleating
agent
dispersant
fabricated
followed
DQS
immobilization
via
dynamic
phenylborate
ester
bond,
obtaining
(defined
Ce@PBD).
Because
mimic
cascade
processes
superoxide
dismutase
catalase,
Ce@PBD
excessive
accumulated
ROS,
showing
strong
antioxidant
anti-inflammatory
properties.
Meanwhile,
receptors
conjunctival
cells
be
stimulated
Ce@PBD,
which
can
relieve
incompleteness
The
animal
experiments
demonstrated
that
significantly
restored
defect
corneal
epithelium
increased
number
goblet
cells,
promotion
secretion,
best
among
commercial
ophthalmic
solutions.
Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 31, 2023
Abstract
The
inadequate
quantity
of
hydrogen
peroxide
(H2O2)
in
cancer
cells
promptly
results
the
constrained
success
chemodynamic
therapy
(CDT).
Significant
efforts
made
throughout
years;
nevertheless,
researchers
are
still
facing
great
challenge
designing
a
CDT
agent
and
securing
H2O2
supply
within
tumor
cell.
In
this
study,
taking
advantage
level
maintenance
mechanism
cells,
nanozyme-based
bimetallic
metal-organic
frameworks
(MOFs)
tandem
reactor
is
fabricated
to
elevate
intracellular
levels,
thereby
enhancing
CDT.
addition,
under
near-infrared
excitation,
upconversion
nanoparticles
(UCNPs)
loaded
into
MOFs
can
perform
photocatalysis
generate
hydrogen,
which
increases
cellular
susceptibility
radicals
induced
from
H2O2,
inhibits
cell
energy,
causes
DNA
damages
induces
apoptosis,
thus
improving
therapeutic
efficacy
synergistically.
proposed
MOFs-mediated
UCNPs-mediated
act
as
combined
with
high
low
toxicity.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
Abstract
Posterior
uveitis
is
a
leading
cause
of
vision
impairment
and
blindness
globally
due
to
its
detrimental
effects
on
the
choroid
retina.
The
condition
worsened
by
oxidative
stress,
which
heightens
inflammation
perpetuates
cycle
damage
that
current
treatments
only
temporarily
relieve.
To
address
this,
novel
treatment
involving
in
situ
crystallization
ultrasmall
cerium
oxide
nanoparticles
(≈3
nm)
mesenchymal
stem
cell
(MSC)
extracellular
vesicles
(EVs)
for
management
primed
mycobacterial
(PMU)
developed.
This
nanohybrid
leverages
individual
synergistic
components
comprehensive
therapeutic
approach.
act
as
nanozyme
reduce
scavenge
excessive
reactive
oxygen
species
(ROS),
while
MSC
EVs,
with
their
biocompatibility,
modulate
inflammatory
infiltration
alleviate
tissue
damage.
system
offers
promising
new
strategy
ocular
diseases
characterized
stress
inflammation.
