Recent advances in Aggregation-Induced Emission in body surface organs DOI Open Access
Hang Li, Tingting Zhang,

Yingying Liao

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 10, 2023

The surface organs mainly comprise the superficial layers of various parts mammalian body including skin, eyes, and ears, which provide solid protection against threats to entire body. Damage could lead many serious diseases or even death. Currently, despite significant advancements in this domain, there remain numerous enigmas that necessitate expeditious resolution, particularly pertaining diagnostic therapeutic objectives. nanomedicine have provided a impetus for development novel approaches diagnosis, bioimaging, therapy organs. aggregation-induced emission (AIE) phenomenon, initially observed by Prof. Ben Zhong Tang, stands out due its contrasting behavior aggregation-caused quenching (ACQ) effect. This discovery has significantly revolutionized field organs, owing remarkable advantages. In review literature, we aim comprehensive summary recent advances AIE lumenogen (AIEgen)-based nanoplatforms detection, imaging, therapeutics organ-related discuss prospects domain. It is hoped will help attract researchers’ attention towards utilization exploration wider range biomedical clinical applications.

Language: Английский

Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine DOI Creative Commons
Yanhong Duo, Lei Han, Yaoqiang Yang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

Citations

19
Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field DOI Creative Commons
Qian He,

Meiyiming Wang,

Zhao Li

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

Citations

17
Unveiling the Role of Alkyl Chain in Boosting Antibacterial Selectivity and Cell Biocompatibility DOI Creative Commons

Ziwei Deng,

Rongyuan Zhang,

Junyi Gong

et al.

JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 675 - 683

Published: Jan. 22, 2025

Cationic amphiphiles have been demonstrated to be superior targeted antibacterial agents whose activity exhibits a close relationship with their alkyl chain substituents. However, systematic and deep investigation of the structure–property is still pending. Meanwhile, cationic risk accumulating in living mammalian cells, which poses great threat biosafety clinical applications. In this study, series amphiphilic aggregation-induced emission luminogens (AIEgens) different chains (TPD-4, TPD-6, TPD-12) developed selective variable against Gram-positive bacteria depending on length. Among them, TPD-6 intermediate length exhibited performance. addition, these AIEgens had negligible invasiveness cells. Molecular dynamics simulations revealed that binding deforming capabilities phospholipid bilayer are responsible for activity. vivo experiments indicated also significant wound-healing abilities bacteria.

Language: Английский

Citations

3
Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers DOI Creative Commons
B Wu,

Kenry Kenry,

Fang Hu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)

Published: Jan. 1, 2024

Abstract With the increasing prevalence of infectious diseases caused by drug‐resistant bacteria, there is an urgent need to develop innovative therapies alternative antibiotics. Among these alternatives, aggregation‐induced emission (AIE) photosensitizers (PSs) stand out with their integrated imaging and therapeutic functionalities, allowing for early monitoring image‐guided ablation bacteria. AIE fluorescent probes unique optical properties excel in selective bacterial imaging. Furthermore, AIE‐enabled reactive oxygen species (ROS)‐mediated antibacterial photodynamic therapy can operate on multiple targets oxidize Also, as they are able specifically target PSs ameliorate limitations small‐scale action ROS. This review methodically discusses different strategies that be employed using targeting including sheltered The challenges future opportunities this emerging field also briefly discussed.

Language: Английский

Citations

16
Fast and Stable Antibacterial Coating of Photosensitive Aggregation‐Induced Emission Luminogens for Disinfection on Medical Devices DOI
Mian Chen,

Ruihua Dong,

Jiayi Song

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 9, 2024

Aggregation-induced emission luminogens (AIEgens) are promising photosensitizers that have exhibited excellent antibacterial ability with abundant reactive oxygen species (ROS) generation. TTCPy-PF6 and TTCPy-Br deposited on the surface of diverse solid substrates through plasma-assistant electrostatic self-assembly. The AIEgens-covered coating can effectively eliminate different pathogenic Gram-positive (G+) bacteria even their multidrug-resistant (MDR) mutants negligible side effects such as cytotoxicity, hemolysis, inflammation. Moreover, AIEgen-coated maintain high stability for long-time usage, which is dependent ROS-mediated disruption attached bacteria. AIEgen-based coatings broad applicability many advantages in ability, great biocompatibility, low possibility antibiotic pollution. robust biological safety would be helpful disinfection medical devices.

Language: Английский

Citations

7
Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides DOI Creative Commons
Dehua Deng, Yong Chang, Wenjing Liu

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 773 - 773

Published: July 29, 2023

Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures small organic molecules peptides with intriguing characteristics (e.g., structure tailoring, facile processability, excellent biocompatibility) have shown outstanding potential development various biosensors. this review, we introduced unique properties for We first discussed applications such electrochemical biosensors as electrode supports enzymes cells signal labels large number electroactive units amplification. Secondly, utilization fluorescent nanomaterials by dyes or was introduced. Thereinto, typical examples based on target-responsive aggregation-induced emission decomposition-induced enhancement were discussed. Finally, colorimetric assays summarized. also briefly addressed challenges future prospects nanostructures.

Language: Английский

Citations

11
Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy DOI
Kun Zhou, Ying Yu, Letian Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29930 - 29941

Published: Oct. 18, 2024

Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity selectively eradicate diseased tissues while minimizing damage normal tissue. Nevertheless, efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, dearth suitable photosensitizers and pronounced imaging-treatment disparity pose challenges. Additionally, implementation via optical fiber implantation carries infection risks necessitates minimally invasive surgery, contradicting PDT's noninvasive advantage. In this study, we introduce brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) develop visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate therapeutic inaccessible conventional PDT, demonstrating significant suppression inflammatory diffusion vivo using AIEgen TBPPM loaded within VLP, which exhibits transmittance 86% thickness 3 mm. This innovative effectively overcomes substantial limitations PDT settings holds promise for advancing phototherapy.

Language: Английский

Citations

4
One‐pot synthesis of tunable fluorescent polyethylene glycol (PEG) polymer for antimicrobial and anticancer theranostics DOI Creative Commons
Dokkari Nagalaxmi Yadav, Dinesh Harijan,

Sunil Venkanna Pogu

et al.

MedComm – Biomaterials and Applications, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 9, 2025

Abstract Poly (ethylene glycol) (PEG), is a well‐known biocompatible and biodegradable polymer with wide range of applications such as surface coating nano/micro materials for improving their biocompatibility, immunological inertness, systemic circulation. However, PEG nonfluorescent material limiting its application in bioimaging. So herein, novel fluorescent was synthesized using facile method. For this, in‐house water‐soluble compound [4,5‐bis‐{(N‐ carboxy methyl benzimidazolium) methyl} acridine] dibromide}] (b‐ACA) used to modify into (PEG‐b‐ACA) by one‐pot PEG‐b‐ACA displayed fluorescence from green red respect the concentration b‐ACA being used. The mixture evaluated antimicrobial antiviral efficacy against E. coli, S. aureus, C. albicans , Bacteriophage Lambda, it showed significant inhibition microbial viral growth. also cellular uptake anticancer 4T1 breast cancer cells, results both. demonstrated that potent antimicrobial, antiviral, agent when compared alone. Therefore, could be an effective various biomedical applications.

Language: Английский

Citations

0
AIE Photosensitizer with Tuned Membrane Interactions for Effective-Gram-Negative Bacteria Elimination DOI
Edward Kamya,

Shangzhao Yi,

Zhongzhong Lu

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Photodynamic antimicrobial therapy (PDAT) for efficient bacterial infection eradication critically relies on photosensitizers (PSs) that can specifically target and disrupt membranes. However, the complex membrane architecture of Gram-negative bacteria poses a significant challenge to efficacy most aggregation-induced emission (AIE) PSs. Herein, we introduce TPQ, an AIE PS meticulously designed overcome this by incorporating outer disruption ability, thereby boosting PDAT against bacteria. TPQ demonstrated excellent microbial imaging potent activity both Gram-positive bacteria, attributed its inherent fluorescence, high singlet oxygen generation, balanced electrostatic hydrophobic interactions with Notably, achieved exceptional (>97% efficacy) while exhibiting minimal cytotoxicity mammalian cells. Furthermore, TPQ-mediated effectively healed Escherichia coli-infected wounds mice models assured biosafety. This work provides valuable insights into rational design PSs highlights synergistic effect advancing applications, particularly recalcitrant infections.

Language: Английский

Citations

0
Metasurface biosensors: Status and prospects DOI Creative Commons
Masanobu Iwanaga, Qi Hu, Youhong Tang

et al.

Applied Physics Reviews, Journal Year: 2025, Volume and Issue: 12(2)

Published: April 4, 2025

Metasurfaces have emerged as a rapidly evolving frontier in the fields of optics and photonics, with growing emphasis on their potential for practical applications. The considerable volume contributions to study metasurfaces has expanded, creating challenges tracking all advancements within this dynamic field. In review, we select practically useful among diverse studied so far. We refer selected hot research topics at beginning, succeedingly outline status several applications that are nearing applications, then focus biosensing particular attention metasurface fluorescence (FL) biosensors, because FL detection is major approach bioscience biotechnology. However, by biosensors not been reviewed an extensive comprehensive manner. Indeed, demonstrated capability detecting wide range biomolecules including nucleic acids proteins, such antigens antibodies. Notably, they offer enhanced sensitivity assays reduced assay time when compared conventional commercial assays. here provide focused review current future directions biosensors.

Language: Английский

Citations

0