Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 14(5), P. 1154 - 1172
Published: Nov. 25, 2023
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122478 - 122478
Published: Jan. 21, 2024
Language: Английский
Citations
23
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract Increasing studies have revealed the importance of mechanical cues in tumor progression, invasiveness and drug resistance. During malignant transformation, changes manifest either properties tissue or cellular ability to sense respond signals. The major focus review is subtle correlation between apoptosis cells from a mechanobiology perspective. To begin, we on intracellular force, examining cell interior, outlining role that cytoskeleton organelle-mediated forces play apoptosis. This article also elucidates mechanisms by which extracellular guide mechanosensing, ultimately triggering activation mechanotransduction pathway impacting Finally, comprehensive examination present status design development anti-cancer materials targeting presented, emphasizing underlying principles. Furthermore, underscores need address several unresolved inquiries enhance our comprehension cancer therapeutics target mechanotransduction.
Language: Английский
Citations
6
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(4), P. 290 - 303
Published: March 7, 2024
Language: Английский
Citations
6
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract Immune checkpoint blockade therapy provides a new strategy for tumor treatment; however, the insufficient infiltration of cytotoxic T cells and immunosuppression in microenvironment lead to unsatisfied effects. Herein, we reported lipid/PLGA nanocomplex (RDCM) co-loaded with photosensitizer Ce6 indoleamine 2,3-dioxygenase (IDO) inhibitor 1MT improve immunotherapy colon cancer. Arginine–glycine–aspartic acid (RGD) as targeting moiety was conjugated on 1,2-distearoyl-snglycero-3-phosphoethanolamine lipid via polyethylene glycol (PEG), programmed cell death-ligand 1 (PD-L1) peptide DPPA (sequence: CPLGVRGK-GGG-d(NYSKPTDRQYHF)) immobilized terminal group PEG matrix metalloproteinase 2 sensitive linker. The were encapsulated PLGA nanoparticles. drug loaded nanoparticles composited RGD modified lecithin form nanocomplexes. When nanocomplexes delivered tumor, released by cleavage 2-sensitive linker PD-L1 binding. facilitated cellular internalization avβ3 integrin. Strong immunogenic death induced 1O2 generated from irradiation under 660 nm laser. inhibited activity IDO reduced inhibition caused kynurenine accumulation microenvironment. RDCM maturation dendritic cells, IDO, markedly recruited proportion tumor-infiltrating CT26 tumor-bearing mice, triggering robust immunological memory effect, thus effectively preventing metastasis. results indicated that dual effects is promising platform targeted photoimmunotherapy
Language: Английский
Citations
5
British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: May 8, 2024
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of great significance, especially given the increasing prevalence in an ageing sedentary population. Together, these impose a substantial socio‐economic burden, demanding innovative therapeutic solutions. This review explores treatment. We commence by examining approaches identifying characterizing atherosclerosis‐associated ncRNAs. then delve into functional aspects development Additionally, we current RNA RNA‐targeting molecules under approval clinical use, offering insights their pharmacological potential. importance improved ncRNA delivery strategies highlighted. Finally, suggest avenues advanced research accelerate use treating mitigating its societal impact.
Language: Английский
Citations
4
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3445 - 3470
Published: March 1, 2025
Advances in nanotechnology have opened new avenues for precision therapy, personalized medicine, and multifunctional theranostics atherosclerosis (AS). This review provides a comprehensive overview of the role nanoparticles (NPs) medicine AS, discussing their applications, challenges, future prospects. The first analyzes current treatment landscape AS outlines potential biological targets therapy. Various nanocarriers, including organic, inorganic, hybrid systems, are evaluated therapeutic potential, with focus on targeted drug delivery, anti-inflammatory vascular repair, plaque stabilization, lipid clearance. Additionally, explores NP preparation methods, emphasizing strategies to enhance loading, stability, controlled release. Finally, translational challenges NP-based therapies, biocompatibility, large-scale production, regulatory hurdles, clinical implementation, critically analyzed. Future directions highlight importance interdisciplinary collaboration technological innovation advancing nanoparticle-based AS.
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: March 20, 2025
Atherosclerosis is the leading cause of cardiovascular disease worldwide, posing not only a significant threat to health but also impairing function multiple organs, with severe cases potentially being life-threatening. Consequently, effective treatment atherosclerosis paramount importance in reducing mortality associated diseases. With advancement nanomedicine and deeper understanding pathological mechanisms underlying atherosclerosis, nanomaterials have emerged as promising platforms for precise diagnosis targeted therapeutic strategies. These materials offer notable advantages, including drug delivery, enhanced bioavailability, improved stability, controlled release. This review provides an overview atherosclerotic plaque development examines nanomaterial-based approaches managing plaques, therapies targeting cholesterol metabolism, anti-inflammatory strategies, macrophage clearance, immunotherapy. Additionally, paper discusses current technical challenges clinical transformation these therapies. Finally, potential future integration nanomaterials, smart artificial intelligence explored.
Language: Английский
Citations
0
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: May 23, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5581 - 5603
Published: June 1, 2024
Lenvatinib (LVN) is a potentially effective multiple-targeted receptor tyrosine kinase inhibitor approved for treating hepatocellular carcinoma, metastatic renal cell carcinoma and thyroid cancer. Nonetheless, poor pharmacokinetic properties including water solubility rapid metabolic, complex tumor microenvironment, drug resistance have impeded its satisfactory therapeutic efficacy. This article comprehensively reviews the uses of nanotechnology in LVN to improve antitumor effects. With characteristic high modifiability loading capacity nano-drug delivery system, an active targeting approach, controllable release, biomimetic strategies been devised deliver target tumors sequence, compensating lack passive targeting. The existing applications advances improving efficacy include longer-term efficiency, achieving higher combination therapy, tracking diagnosing application reducing toxicity. Therefore, using multiple combined with photothermal, photodynamic, immunoregulatory therapies overcomes multi-drug resistance, regulates unfavorable yields synergistic In brief, nano-LVN system has brought light war against cancer while at same time effect. More intelligent multifunctional nanoparticles should be investigated further converted into clinical future.
Language: Английский
Citations
3