Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(2), P. 1036 - 1047
Published: Jan. 4, 2024
Cardiovascular
disease
(CVD)
development
may
be
linked
to
persistent
organic
pollutants
(POPs),
including
organochlorine
compounds
(OCs)
and
perfluoroalkyl
polyfluoroalkyl
substances
(PFAS).
To
explore
underlying
mechanisms,
we
investigated
metabolites,
proteins,
genes
linking
POPs
with
CVD
risk.
We
used
data
from
a
nested
case-control
study
on
myocardial
infarction
(MI)
stroke
the
Swedish
Mammography
Cohort
–
Clinical
(n
=
657
subjects).
OCs,
PFAS,
multiomics
(9511
liquid
chromatography-mass
spectrometry
(LC-MS)
metabolite
features;
248
proteins;
8110
gene
variants)
were
measured
in
baseline
plasma.
POP-related
omics
features
selected
using
random
forest
followed
by
Spearman
correlation
adjusted
for
confounders.
From
these,
CVD-related
conditional
logistic
regression.
Finally,
29
(for
OCs)
12
PFAS)
unique
associated
CVD.
One
subpattern,
driven
lipids
inflammatory
MI
(OR
2.03;
95%
CI
1.47;
2.79),
age,
BMI,
correlated
negatively
PFAS.
Another
carnitines,
1.55;
1.16;
2.09),
but
not
This
imply
that
OCs
PFAS
associate
different
patterns
opposite
effects
risk,
more
research
is
needed
disentangle
potential
modifications
other
factors.
Trends in Ecology & Evolution,
Journal Year:
2022,
Volume and Issue:
38(1), P. 35 - 43
Published: Oct. 13, 2022
Non-target
organisms
are
globally
exposed
to
herbicides.
While
many
herbicides
-
for
example,
glyphosate
were
initially
considered
safe,
increasing
evidence
demonstrates
that
they
have
profound
effects
on
ecosystem
functions
via
altered
microbial
communities.
We
provide
a
comprehensive
framework
how
herbicide
residues
may
modulate
ecosystem-level
outcomes
alteration
of
microbiomes.
The
changes
in
soil
microbiome
likely
influence
key
nutrient
cycling
and
plant-soil
processes.
Herbicide-altered
affects
plant
animal
performance
can
trophic
interactions
such
as
herbivory
pollination.
These
expected
lead
even
evolutionary
consequences
both
microbes
hosts.
Tackling
the
threats
caused
by
agrochemicals
services
requires
tools
solutions
based
understanding
microbe-mediated
risks.
Environment International,
Journal Year:
2024,
Volume and Issue:
186, P. 108569 - 108569
Published: March 20, 2024
Environmental
toxicants
(ETs)
are
associated
with
adverse
health
outcomes.
Here
we
hypothesized
that
exposures
to
ETs
linked
obesity
and
insulin
resistance
partly
through
a
dysbiotic
gut
microbiota
changes
in
the
serum
levels
of
secondary
bile
acids
(BAs).
Serum
BAs,
per-
polyfluoroalkyl
substances
(PFAS)
additional
twenty-seven
were
measured
by
mass
spectrometry
264
Danes
(121
men
143
women,
aged
56.6
±
7.3
years,
BMI
29.7
6.0
kg/m
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(5), P. 708 - 708
Published: April 29, 2021
It
is
generally
accepted
that
gut
microbiota,
inflammation
and
obesity
are
linked
to
the
development
of
cardiovascular
diseases
other
chronic/non-communicable
pathological
conditions,
including
cancer,
neurodegenerative
ageing-related
disorders.
In
this
scenario,
oxidative
stress
plays
a
pivotal
role.
Evidence
suggests
global
dietary
patterns
may
represent
tool
in
counteracting
stress,
thus
preventing
onset
related
stress.
More
specifically,
based
on
regular
consumption
fruits
vegetables
(i.e.,
Mediterranean
diet)
have
been
licensed
by
various
national
nutritional
guidelines
many
countries
for
their
health-promoting
effects.
Such
patterns,
indeed,
result
being
rich
specific
components,
such
as
fiber,
minerals,
vitamins
antioxidants,
whose
beneficial
effects
human
health
widely
reported.
This
potential
nutraceutical
power
components.
manuscript,
we
summarize
most
relevant
evidence
reporting
impact
antioxidants
microbiota
composition,
obesity,
underline
implicated
complex
interplay
between
suggesting
possible
role
modulation
chronic
maintenance
wellness.
Do
all
roads
lead
Rome?
Animal Microbiome,
Journal Year:
2021,
Volume and Issue:
3(1)
Published: Dec. 1, 2021
Many
parts
of
the
animal
body
harbor
microbial
communities,
known
as
animal-associated
microbiomes,
that
affect
regulation
physiological
functions.
Studies
in
human
and
models
have
demonstrated
reproductive
biology
such
microbiomes
also
interact.
However,
this
concept
is
poorly
studied
wild
species
little
about
implications
to
fertility,
parental/offspring
health,
survival
natural
habitats.
The
objective
review
(1)
specify
interactions
between
animals'
biology,
including
signaling,
pregnancy,
offspring
development,
their
with
an
emphasis
on
(2)
identify
important
research
gaps
well
areas
for
further
studies.
While
present
tract
play
most
direct
role,
other
bodily
may
contribute
facilitating
reproduction.
In
fish,
amphibians,
reptiles,
birds,
mammals,
endogenous
processes
related
host
physiology
behavior
(visual
olfactory
signals,
copulation)
can
both
influence
be
influenced
by
structure
function
communities.
addition,
exposures
maternal
mammals
(through
vagina,
skin,
milk)
shape
which,
turn,
affects
health
later
life.
Importantly,
all
species,
host-associated
are
environmental
variations.
There
still
limited
literature
animals
compared
large
model
humans.
few
studies
clearly
highlight
necessity
increased
rare
endangered
optimize
conservation
efforts
situ
ex
situ.
Thus,
link
reproduction
emerging
critical
component
conservation.