OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort DOI Creative Commons
Tessa Schillemans, Yingxiao Yan, Anton Ribbenstedt

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(2), P. 1036 - 1047

Published: Jan. 4, 2024

Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) stroke the Swedish Mammography Cohort – Clinical (n = 657 subjects). OCs, PFAS, multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma. POP-related omics features selected using random forest followed by Spearman correlation adjusted for confounders. From these, CVD-related conditional logistic regression. Finally, 29 (for OCs) 12 PFAS) unique associated CVD. One subpattern, driven lipids inflammatory MI (OR 2.03; 95% CI 1.47; 2.79), age, BMI, correlated negatively PFAS. Another carnitines, 1.55; 1.16; 2.09), but not This imply that OCs PFAS associate different patterns opposite effects risk, more research is needed disentangle potential modifications other factors.

Language: Английский

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy DOI
Hui Duan, Leilei Yu, Fengwei Tian

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 742, P. 140429 - 140429

Published: June 25, 2020

Language: Английский

Citations

180

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota DOI
Anna E. Lindell, Maria Zimmermann‐Kogadeeva, Kiran Raosaheb Patil

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(7), P. 431 - 443

Published: Jan. 31, 2022

Language: Английский

Citations

134

Obesity II: Establishing causal links between chemical exposures and obesity DOI
Jerrold J. Heindel, Sarah Howard, Keren Agay‐Shay

et al.

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 199, P. 115015 - 115015

Published: April 5, 2022

Language: Английский

Citations

131

Ecosystem consequences of herbicides: the role of microbiome DOI Creative Commons
Suvi Ruuskanen, Benjamin Fuchs, Riitta Nissinen

et al.

Trends in Ecology & Evolution, Journal Year: 2022, Volume and Issue: 38(1), P. 35 - 43

Published: Oct. 13, 2022

Non-target organisms are globally exposed to herbicides. While many herbicides - for example, glyphosate were initially considered safe, increasing evidence demonstrates that they have profound effects on ecosystem functions via altered microbial communities. We provide a comprehensive framework how herbicide residues may modulate ecosystem-level outcomes alteration of microbiomes. The changes in soil microbiome likely influence key nutrient cycling and plant-soil processes. Herbicide-altered affects plant animal performance can trophic interactions such as herbivory pollination. These expected lead even evolutionary consequences both microbes hosts. Tackling the threats caused by agrochemicals services requires tools solutions based understanding microbe-mediated risks.

Language: Английский

Citations

97

Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity DOI Creative Commons
Partho Sen, Yong Fan, Jennifer J. Schlezinger

et al.

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108569 - 108569

Published: March 20, 2024

Environmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs linked obesity and insulin resistance partly through a dysbiotic gut microbiota changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- polyfluoroalkyl substances (PFAS) additional twenty-seven were measured by mass spectrometry 264 Danes (121 men 143 women, aged 56.6 ± 7.3 years, BMI 29.7 6.0 kg/m

Language: Английский

Citations

20

The release, degradation, and distribution of PVC microplastic-originated phthalate and non-phthalate plasticizers in sediments DOI
Gayatri Panthi, Rishikesh Bajagain, Dhiraj Kumar Chaudhary

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134167 - 134167

Published: March 29, 2024

Language: Английский

Citations

20

Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review DOI
Shahnawaz Mohammad, Md Rezaul Karim, Safia Iqbal

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 281, P. 127595 - 127595

Published: Jan. 3, 2024

Language: Английский

Citations

19

Probiotics and gut microbiome − Prospects and challenges in remediating heavy metal toxicity DOI
K. B. Arun, Aravind Madhavan, Raveendran Sindhu

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 420, P. 126676 - 126676

Published: July 17, 2021

Language: Английский

Citations

101

Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation DOI Creative Commons
Andrea Deledda, Giuseppe Annunziata, Gian Carlo Tenore

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 708 - 708

Published: April 29, 2021

It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases other chronic/non-communicable pathological conditions, including cancer, neurodegenerative ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests global dietary patterns may represent tool in counteracting stress, thus preventing onset related stress. More specifically, based on regular consumption fruits vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines many countries for their health-promoting effects. Such patterns, indeed, result being rich specific components, such as fiber, minerals, vitamins antioxidants, whose beneficial effects human health widely reported. This potential nutraceutical power components. manuscript, we summarize most relevant evidence reporting impact antioxidants microbiota composition, obesity, underline implicated complex interplay between suggesting possible role modulation chronic maintenance wellness. Do all roads lead Rome?

Language: Английский

Citations

99

Interactions between reproductive biology and microbiomes in wild animal species DOI Creative Commons
Pierre Comizzoli, Michael L. Power, Sally L. Bornbusch

et al.

Animal Microbiome, Journal Year: 2021, Volume and Issue: 3(1)

Published: Dec. 1, 2021

Many parts of the animal body harbor microbial communities, known as animal-associated microbiomes, that affect regulation physiological functions. Studies in human and models have demonstrated reproductive biology such microbiomes also interact. However, this concept is poorly studied wild species little about implications to fertility, parental/offspring health, survival natural habitats. The objective review (1) specify interactions between animals' biology, including signaling, pregnancy, offspring development, their with an emphasis on (2) identify important research gaps well areas for further studies. While present tract play most direct role, other bodily may contribute facilitating reproduction. In fish, amphibians, reptiles, birds, mammals, endogenous processes related host physiology behavior (visual olfactory signals, copulation) can both influence be influenced by structure function communities. addition, exposures maternal mammals (through vagina, skin, milk) shape which, turn, affects health later life. Importantly, all species, host-associated are environmental variations. There still limited literature animals compared large model humans. few studies clearly highlight necessity increased rare endangered optimize conservation efforts situ ex situ. Thus, link reproduction emerging critical component conservation.

Language: Английский

Citations

58