Assessing the hepatotoxicity of PFOA, PFOS, and 6:2 Cl-PFESA in black-spotted frogs (Rana nigromaculata) and elucidating potential association with gut microbiota

Environmental Pollution, Journal Year: 2022, Volume and Issue: 312, P. 120029 - 120029

Published: Aug. 28, 2022

Language: Английский

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Adverse effects of polystyrene microplastics in the freshwater commercial fish, grass carp (Ctenopharyngodon idella): Emphasis on physiological response and intestinal microbiome

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 856, P. 159270 - 159270

Published: Oct. 6, 2022

Language: Английский

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Impact of per- and polyfluorinated alkyl substances (PFAS) on the marine environment: Raising awareness, challenges, legislation, and mitigation approaches under the One Health concept

Marine Pollution Bulletin, Journal Year: 2023, Volume and Issue: 194, P. 115309 - 115309

Published: Aug. 15, 2023

Per- and polyfluorinated alkyl substances (PFAS) have long been known for their detrimental effects on the ecosystems living organisms; however long-term impact marine environment is still insufficiently recognized. Based PFAS persistence bioaccumulation in complex food network, adverse will be exacerbated by global processes such as climate change synergies with other pollutants, like microplastics. The range of fluorochemicals currently included umbrella has significantly expanded due to updated OECD definition, raising new concerns about poorly understood dynamics negative ocean wildlife human health. Mitigation challenges approaches, including biodegradation studied materials environmental removal are proposed here, highlighting importance ongoing monitoring bridging research gaps. EU regulations, good practices legal frameworks discussed, emphasis recommendations improving ecosystem management.

Language: Английский

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Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 15, 2023

Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people's health wellbeing. This focus has created lifestyles with high stress levels, associated overconsumption of unhealthy foods little exercise, which negatively affect lives, subsequently lead to development pathologies, including neurodegenerative psychiatric disorders. Prioritizing a healthy lifestyle maintain wellbeing may slow onset or reduce severity pathologies. It is win-win for everyone; individuals. A balanced increasingly being adopted globally, many doctors encouraging meditation prescribing non-pharmaceutical interventions treat depression. In disorders, inflammatory response system brain (neuroinflammation) activated. Many risks factors now known be linked neuroinflammation such as stress, pollution, saturated trans fat diet. On other hand, studies habits anti-inflammatory products lower levels reduced risk Sharing protective critical so that individuals can make informed choices promote positive aging throughout their lifespan. Most strategies manage diseases palliative because neurodegeneration been progressing silently decades before symptoms appear. Here, we preventing by adopting an integrated "healthy" approach. review summarizes role

Language: Английский

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Gut microbiota: a non-target victim of pesticide-induced toxicity

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 15, 2023

The human gut microbiota can be potentially disrupted due to exposure of various environmental contaminants, including pesticides. These contaminants enter into non-target species in multiple ways and cause potential health risks. microbiota-derived metabolites have a significant role maintaining the host's by regulating metabolic homeostasis. An imbalance this homeostasis result development diseases their pathogenesis. Pesticides hazardous effects on microbiota, which is evident few recent studies. Therefore, there an urgent need explore effect pesticide microbiota-mediated changes host, may provide better understanding pesticide-induced toxicity. present review summarizes turn, induces release secondary that could lead host effects.

Language: Английский

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The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123732 - 123732

Published: March 8, 2024

The gut-brain axis is a crucial interface between the central nervous system and gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in microbiota, which may affect communication, impacting aspects of brain function behavior. This systematic review literature aims evaluate whether deleterious effects on due metal could be mediated by changes microbiota profile. Animal studies involving metals comparison with control group evaluated neuropsychological outcomes and/or molecular along analysis composition were reviewed. authors independently assessed for inclusion, extracted data risk bias using protocol Systematic Review Center Laboratory Experimentation (SYRCLE) preclinical studies. A search 3 databases yielded 16 eligible focused lead (n = 10), cadmium 1), mercury 3), manganese combined Pb Mn 1). animal species rats 7), mice 4), zebrafish carp 1) fruit fly Heavy found adversely cognitive function, behavior, neuronal morphology. Moreover, was associated abundance specific bacterial phyla, Firmicutes Proteobacteria, play roles health. In some studies, these alterations correlated learning memory impairments mood disorders. interplay suggests induce direct indirect through contributing neurotoxicity development However, small number papers under makes it difficult draw definitive conclusions. Further research warranted unravel underlying mechanisms translational implications human

Language: Английский

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Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 27, 2024

Abstract Environmental pollutants from different chemical families may reach the gut microbiome, where they can be metabolized and transformed. However, how our symbionts respond to exposure environmental pollution is still underexplored. In this observational, cohort study, we aim investigate influence of on microbiome composition potential activity by shotgun metagenomics. We select as a case study population living in highly polluted area Campania region (Southern Italy), proposed an ideal field for exposomic studies compare fecal 359 subjects areas with high, medium low pollution. highlight changes functionality that were driven exposure. Subjects show higher blood concentrations dioxin heavy metals, well increase microbial genes related degradation and/or resistance these molecules. Here demonstrate dramatic effect xenobiotics have communities, shaping their boosting selection strains degrading capacity. The considered pivotal player environment-health interaction contribute detoxifying toxic compounds should taken into account when developing risk assessment models. was registered at ClinicalTrials.gov identifier NCT05976126.

Language: Английский

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Cancer, deuterium, and gut microbes: A novel perspective

Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: unknown, P. 100215 - 100215

Published: Jan. 1, 2025

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Probiotics and gut microbiota modulation: implications for skin health and disease management

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 23, 2025

Language: Английский

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Environmental exposure to pyrethroid pesticides in a nationally representative sample of U.S. adults and children: The National Health and Nutrition Examination Survey 2007–2012

Environmental Pollution, Journal Year: 2020, Volume and Issue: 267, P. 115489 - 115489

Published: Aug. 29, 2020

Language: Английский

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