Published: Jan. 1, 2024
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Language: Английский
Asian Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
American Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 232(4), P. S105 - S123
Published: April 1, 2025
Language: Английский
Citations
0
INTERNATIONAL NEUROLOGICAL JOURNAL, Journal Year: 2025, Volume and Issue: 21(2), P. 130 - 138
Published: April 24, 2025
Background. Endometriosis has a significant impact on the quality of life patients, as it is source debilitating pain syndrome, leading to depression, anxiety and sleep disorders. Therefore, studying possibilities effective treatment this disease assessing indicators patients relevant clinical task. The purpose was investigate in with endometriosis using assessment index, presence intensity well neurological disorders dynamics. Materials methods. One hundred twenty genital aged 19 44 years were divided into 2 study groups: one group, hormone therapy prescribed after laparoscopic removal endometrioma, another — peptide immunocorrection. During monitoring, index assessed, effect dynamics regression symptoms its consequences analyzed. Results. Before start treatment, at relatively low level: 41.0 ± 4.8 points group 1 2. In 1, reached maximum 6 months surgery 77.0 5.5 points, which 75.0 % higher compared baseline. 2, similar an increase observed, end observation period 84.0 3.9 exceeding baseline by 104.9 %. both groups throughout entire we observed decrease gradual number complaining insomnia, depressive anxiety. Conclusions. Surgical endometriosis, prescription restoration immune homeostasis involved organs are components comprehensive management category patients. Reducing chronic pain, subsequently elimination, inevitably improves overall condition their life.
Language: Английский
Citations
0
iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109298 - 109298
Published: Feb. 20, 2024
Highlights•Interdisciplinary trials on endometriosis are experiencing rapid growth•Patient-centered multidisciplinary management represents the future direction•Employing interdisciplinary approaches comes with challenges in research•Deeper understanding of requires more collaborationSummaryEndometriosis is a chronic multisystem disease associated immunological, genetic, hormonal, psychological, and neuroscientific factors, leading to significant socioeconomic impact worldwide. Though ideal approach, there remains scarcity published clinical at present. Here, we have conducted comprehensive analysis characteristics issues based registration database ClinicalTrials.gov. Among all 387 trials, 30% (116) were identified as interdisciplinary, mostly Europe North America, fully funded by non-industrial sources. We documented growth both patient-centered collaboration between fundamental biomedical science applied medicine. However, compared traditional obstetric-gynecological studies exhibited negative such less likely be randomized report results. Our study provides insights for trial investigators may contribute fostering greater medical research.Graphical abstract
Language: Английский
Citations
3
Published: March 18, 2024
Artificial intelligence (AI) is experiencing advances and integration in all medical specializations, this creates excitement but also concerns. This narrative review aims at a critical assessment of the state art AI field endometriosis adenomyosis. By enabling automation, may speed up some routine tasks, decreasing gynecologists’ risk burnout, as well them to spend more time interacting with their patients, increasing efficiency patients’ perception being taken care of. Surgery benefit from AI, especially through its robotic surgery systems. improve detection anatomical structures enhance surgical outcomes by combining intra-operative findings pre-operative imaging. Not only, promises quality facilitating clinical research introduction decision support tools that can diagnostic predict treatment effectiveness side effects, reproductive prognosis cancer risk. However, concerns exist regarding fact good data used tool development compliance sharing guidelines are crucial. Also, professionals worried render certain specialists obsolete. said, likely become well-liked team member rather than usurper.
Language: Английский
Citations
2
Published: May 21, 2024
Endometriosis is a prevalent chronic inflammatory disease characterized by considerable delay between initial symptoms and diagnosis through surgery. The pressing need for timely, non-invasive diagnostic solution underscores the focus of current research efforts. This study examines potential menstrual blood lipidome. lipid profile 39 samples (23 women with endometriosis 16 patient control group) was acquired using reverse-phase high-performance liquid chromatography-mass spectrometry LipidMatch processing identification. Profiles were normalized based on total ion counts. Significant differences in lipids determined Mann-Whitney test. Lipids model, logistic regression, selected combination variance importance projection filters Akaike information criteria. Levels ceramides, sphingomyelins, cardiolipins, triacylglycerols, acyl- alkenyl-phosphatidylethanolamines, alkenyl-phosphatidylcholines increased, while alkyl-phosphatidylcholines decreased cases endometriosis. PE P-16:0/18:1 CL 16:0_18:0_22:5_22:6 serve as marker exhibiting sensitivity 81% specificity 85%. approach dried spots holds promise an alternative to traditional methods screening.
Language: Английский
Citations
2
Genes, Journal Year: 2024, Volume and Issue: 15(6), P. 723 - 723
Published: June 1, 2024
Uterine pathologies pose a challenge to women’s health on global scale. Despite extensive research, the causes and origin of some these common disorders are not well defined yet. This study presents comprehensive analysis transcriptome data from diverse datasets encompassing relevant uterine such as endometriosis, endometrial cancer leiomyomas. Leveraging Comparative Analysis Shapley values (CASh) technique, we demonstrate its efficacy in improving outcomes classical differential expression transcriptomic derived microarray experiments. CASh integrates game algorithm with Bootstrap resampling, offering robust statistical framework mitigate impact potential outliers data. Our findings unveil novel insights into molecular signatures underlying gynecological disorders, highlighting valuable tool for enhancing precision transcriptomics analyses complex biological contexts. research contributes deeper understanding gene patterns biomarkers associated pathologies, implications future diagnostic therapeutic strategies.
Language: Английский
Citations
2
Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(10), P. 101769 - 101769
Published: Oct. 1, 2024
Language: Английский
Citations
2
Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 162 - 162
Published: Dec. 27, 2024
Endometriosis, a chronic hormone-dependent condition affecting 10% of women globally, impacts pelvic organs and occasionally distant sites, causing pain, infertility, sexual dysfunction. Biomarkers such as IL-8, IL-10, BDNF influence inflammation, nerve sensitization, pain. This study investigates their relationship with quality life, focusing on dyspareunia related dysfunctions, assessed using the Female Sexual Function Index (FSFI). Dyspareunia, prominent symptom endometriosis, is linked to lower FSFI scores in domains desire (mean 3.38), satisfaction 3.28), pain 3.07). Elevated IL-8 tissue levels negatively correlated (r = −0.649, p < 0.05) −0.813, 0.01). Similarly, higher were associated increased −0.435, 0.01) reduced −0.252, 0.05). Patient factors endometriosis severity 26.3, surgical history satisfaction. Conversely, physical activity improved (p enhanced lubrication 0.05), likely through inflammation better circulation. These findings highlight complex interplay between biomarkers, individual factors, dysfunction underscoring need for personalized therapeutic approaches.
Language: Английский
Citations
2