Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Irene Mignini,

Linda Galasso,

Giulia Piccirilli

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1532 - 1532

Published: Dec. 14, 2024

Oxidative stress has been described as one of the main drivers intracellular damage and metabolic disorders leading to syndrome, a major health problem worldwide. In particular, free radicals alter lipid metabolism promote accumulation in liver, existing hepatic facet dysfunction-associated steatotic liver disease (MASLD). Recent literature highlighted how nicotine, especially if associated with high-fat diet, exerts negative effect on induction progression MASLD by upregulating inflammation increasing oxidative stress, abdominal fat lipolysis, lipogenesis. Moreover, considerable evidence shows central role intestinal dysbiosis pathogenesis impact nicotine-induced gut microbiome. This results an intricate network which stands at intersection point between microbiome, MASLD. The aim this review is delve into molecular mechanisms linking tobacco smoking MASLD, focusing microbiota modifications their development.

Language: Английский

The CYP4/20-HETE/GRP75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease DOI Creative Commons

James P. Hardwick,

Byoung‐Joon Song,

Paul Rote

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Introduction Metabolic-dysfunction-associated steatosis liver disease (MASLD) is a progressive from simple steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic diseases (CLDs) can lead to portal hypertension, which major cause of complications cirrhosis. CLDs structural alterations across the through increased contents extracellular matrix (ECM), driving dysfunction sinusoidal endothelial cells (LSECs) alongside hepatic stellate (HSCs) activated resident or infiltrating immune cells. Bioactive arachidonic metabolites have diverse roles in progression MASLD. Both secreted levels 20-hydroxyeicosatetraenoic acid (20-HETE) epoxyeicosatrienoic (EET) are elevated patients with Methods CLD samples were evaluated for changes free fatty acids (FFA), cholesterol, bilirubin, bile acid, reactive oxygen species (ROD), lipid peroxidation, myeloperoxidase activity hydroxyproline evaluate degrees damage fibrosis. To address role CYP4/20-HETE/GPR75 axis, we measured amount synthesis 20-HETE CLD, specifically during Additionally, gene expression protein GPR75, high-affinity receptor patient samples. Results We observed an increase Increased correlated CYP4A11 genes but not CYP4F2. These results confirmed by P4504A11 decreased P4504F2 development The 20-HETE, Interestingly, GPR75 mRNA steatohepatitis dramatically dropped cirrhosis then HCC. Also, mirrored their levels. Discussion indicate that subsequent coordinately regulated MASLD may multiple roles, including activation peroxisome proliferator-activated α (PPARα) either cell proliferation vasoconstriction hypertension abrupt reduction also be due serving as feedback mechanism via , leading reduced expression. This work illustrates key correlations associated axis humans.

Language: Английский

Citations

1
Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review DOI Creative Commons
Gabriela Svobodová,

Martin Horní,

Eva Velecká

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism closely related to oxidative stress, leading cellular lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress. The detrimental effect stress usually accompanied changes in antioxidant defense mechanisms, with the alterations enzymes expression/activities during MASLD development progression reported many clinical experimental studies. This review will provide comprehensive overview present research on MASLD-induced catalytic activity expression main (superoxide dismutases, catalase, glutathione peroxidases, S-transferases, reductase, NAD(P)H:quinone oxidoreductase) level non-enzymatic glutathione. Furthermore, an therapeutic effects vitamin E be presented. Generally, at beginning development, expression/activity increases protect organisms against increased production reactive oxygen species. However, advanced stage MASLD, several antioxidants generally decreases due damage hepatic extrahepatic cells, which further exacerbates damage. Although results obtained patients, various animal or cell models have been inconsistent, taken together importance has clearly shown.

Language: Английский

Citations

4
Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities DOI Creative Commons
Tom Ryu, Young Woon Chang, Jeong‐Ju Yoo

et al.

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 47, P. 119 - 128

Published: Feb. 14, 2025

Language: Английский

Citations

0
Die Darm-Leber-Achse und die metabolische Dysfunktion-assoziierte steatotische Lebererkrankung DOI
Münevver Demir, Frank Tacke,

M Müller-Schilling

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Citations

0
The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis DOI Open Access
Patrycja Jakubek, Karol Parchem, Mariusz R. Więckowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7827 - 7827

Published: July 17, 2024

Oxidative stress has been known about in biological sciences for several decades; however, the understanding of this concept evolved greatly since its foundation. Over past years, reactive oxygen species, once viewed as solely deleterious, have become recognized intrinsic components life. In contrast, antioxidants, initially believed to be cure-all remedies, failed prove their efficacy clinical trials. Fortunately, research on health-promoting properties antioxidants ongoing. Subsequent years showed that former assumption all acted similarly was oversimplified. Redox-active compounds differ chemical structures, electrochemical properties, mechanisms action, and bioavailability; therefore, protecting against oxidative also varies. review, we discuss changing perception sources, emphasizing everyday-life exposures, particularly those dietary origin. Finally, posit a better physicochemical outcomes is crucial fully utilize beneficial impact health.

Language: Английский

Citations

3
Cell Membrane-Derived Nanoparticles as Biomimetic Nanotherapeutics to Alleviate Fatty Liver Disease DOI
Alap Ali Zahid, Aishik Chakraborty, Yasmeen Shamiya

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39117 - 39128

Published: July 18, 2024

The prevalence of metabolic dysfunction associated-steatotic liver disease (MASLD) (formerly known as nonalcoholic fatty disease; NAFLD) is estimated at around 32% the world's population, resulting in a major healthcare concern recent times. Current pharmaceutical methods lack efficacy for treatment because suboptimal pharmacokinetic parameters including poor bioavailability, short half-life, and premature clearance. Designing an efficient drug delivery system that provides protective environment critical addressing these challenges. Such should aim to enhance cellular uptake drugs, improve their reduce chances rapid Here, we developed nanoengineered natural cell membrane-derived nanoparticles (CMNs) incorporated with model drug, rosuvastatin, bilayer assembly CMNs accumulation lipids hepatocytes, hallmark MASLD. We used extrusion technique develop self-assembled precise size control compared shearing method. Interestingly, prepared were found be nonphagocytic, representing 1.13% phosphatidylserine receptors on healthy cells, which allows possibility use stealth delivery. Furthermore, exhibit higher drug-loading efficiency, excellent cytocompatibility, enhanced internalization capabilities. Moreover, show rosuvastatin-loaded vitro MASLD efficiently reduced hepatocyte lipid accumulation, total cholesterol (26.8 ± 3.1%) triglycerides (11.8 0.8%), negative control. Taken together, biomimetic drug's bioactivity hepatic establishing foundation further investigation this treating

Language: Английский

Citations

1
Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Irene Mignini,

Linda Galasso,

Giulia Piccirilli

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1532 - 1532

Published: Dec. 14, 2024

Oxidative stress has been described as one of the main drivers intracellular damage and metabolic disorders leading to syndrome, a major health problem worldwide. In particular, free radicals alter lipid metabolism promote accumulation in liver, existing hepatic facet dysfunction-associated steatotic liver disease (MASLD). Recent literature highlighted how nicotine, especially if associated with high-fat diet, exerts negative effect on induction progression MASLD by upregulating inflammation increasing oxidative stress, abdominal fat lipolysis, lipogenesis. Moreover, considerable evidence shows central role intestinal dysbiosis pathogenesis impact nicotine-induced gut microbiome. This results an intricate network which stands at intersection point between microbiome, MASLD. The aim this review is delve into molecular mechanisms linking tobacco smoking MASLD, focusing microbiota modifications their development.

Language: Английский

Citations

0