COVID-19 vaccine hesitancy and associated factors among infertile couples undergoing assisted reproductive treatment DOI Creative Commons
Xinyan Wang, Huiyan Wang, Aijun Du

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 27, 2022

Although periconception vaccination is important to maternal and neonatal health, little known about the COVID-19 vaccine hesitancy among infertile couples seeking fertility treatment. Thus, we conducted this survey patients in a reproductive medicine center, between September 2021 December 2021, estimate prevalence of its influencing factors. Information was collected through face-to-face interviews volunteers. Among 987 included interviewees, 17.33% reported primary vaccination, 25.63% booster 32.32% delayed vaccination. Hesitancy associated with unexplained infertility (OR: 1.77, 95% CI: 1.05-2.98), ongoing IVF treatment 2.17, 1.22-3.89), concerns for safety 4.13, 2.66-6.42), effectiveness 1.62, 1.15-2.28), influence on pregnancy 2.80, 1.68-4.67). These factors were also Delay inversely college or above degree 0.49, 0.27-0.87), previous history influenza 0.67, 0.46-0.98), positively 7.78, 5.01-12.07). It necessary carry out targeted education program by health professionals publicize benefits reduce resistance couples.

Language: Английский

SARS-CoV-2, fertility and assisted reproduction DOI Creative Commons
Barış Ata, Nathalie Vermeulen, Edgar Mocanu

et al.

Human Reproduction Update, Journal Year: 2022, Volume and Issue: 29(2), P. 177 - 196

Published: Nov. 14, 2022

In 2020, SARS-CoV-2 and the COVID-19 pandemic had a huge impact on access to provision of ART treatments. Gradually, knowledge virus its transmission has become available, allowing activities resume. Still, questions human gametes fertility remain.

Language: Английский

Citations

81
Effect of COVID-19 vaccination on the timing and flow of menstrual periods in two cohorts DOI Creative Commons
Alexandra Alvergne, Ee Von Woon, Victoria Male

et al.

Frontiers in Reproductive Health, Journal Year: 2022, Volume and Issue: 4

Published: July 25, 2022

COVID-19 vaccination protects against the potentially serious consequences of SARS-CoV-2 infection, but some people have been hesitant to receive vaccine because reports that it could affect menstrual bleeding. To determine whether this occurs we prospectively recruited a cohort 79 individuals, each whom recorded details at least three consecutive cycles, during which time they received one dose vaccine. In spontaneously cycling participants, was associated with delay next period, change reversed in subsequent unvaccinated cycles. No detected those taking hormonal contraception. explore hypotheses about mechanism by these changes occur, retrospectively larger cohort, 1,273 who had kept record their cycle and dates. found trend toward use combined contraception being protective reporting delayed suggesting following may be mediated perturbations ovarian hormones. However, were unable detect clear association between timing within changes. Our findings suggest can lengthen effect Importantly, find returns its pre-vaccination length

Language: Английский

Citations

73
The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis DOI
Drieda Zaçe, Elisa Gatta,

L. Petrella

et al.

Vaccine, Journal Year: 2022, Volume and Issue: 40(42), P. 6023 - 6034

Published: Sept. 12, 2022

Language: Английский

Citations

68
An update of polycystic ovary syndrome: causes and therapeutics options DOI
Abeer M. Rababa’h,

Bayan R. Matani,

Alaa Yehya

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(10), P. e11010 - e11010

Published: Oct. 1, 2022

Language: Английский

Citations

40
The risk of miscarriage following COVID-19 vaccination: a systematic review and meta-analysis DOI Creative Commons
Michael P. Rimmer, Jhia Jiat Teh, Scott C. Mackenzie

et al.

Human Reproduction, Journal Year: 2023, Volume and Issue: 38(5), P. 840 - 852

Published: Feb. 16, 2023

Abstract STUDY QUESTION What is the risk of miscarriage among pregnant women who received any COVID-19 vaccines? SUMMARY ANSWER There no evidence that vaccines are associated with an increased miscarriage. WHAT IS KNOWN ALREADY In response to pandemic, mass roll-out helped boost herd immunity and reduced hospital admissions, morbidity, mortality. Still, many were concerned about safety for pregnancy, which may have limited their uptake those planning a pregnancy. DESIGN, SIZE, DURATION For this systematic review meta-analysis, we searched MEDLINE, EMBASE, Cochrane CENTRAL from inception until June 2022 using combination keywords MeSH terms. PARTICIPANTS/MATERIALS, SETTING, METHODS We included observational interventional studies enrolled evaluated available compared placebo or vaccination. primarily reported on in addition ongoing pregnancy and/or live birth. MAIN RESULTS AND THE ROLE OF CHANCE data 21 (5 randomized trials 16 studies) reporting 149 685 women. The pooled rate vaccine was 9% (n = 14 749/123 185, 95% CI 0.05–0.14). Compared vaccination, did not higher (risk ratio (RR) 1.07, 0.89–1.28, I2 35.8%) had comparable rates birth (RR 1.00, 0.97–1.03, 10.72%). LIMITATIONS, REASONS FOR CAUTION Our analysis varied reporting, high heterogeneity bias across studies, limit generalizability confidence our findings. WIDER IMPLICATIONS FINDINGS increase reproductive age. current remains larger population needed further evaluate effectiveness vaccination FUNDING/COMPETING INTEREST(S) No direct funding provided support work. M.P.R. funded by Medical Research Council Centre Reproductive Health Grant No: MR/N022556/1. B.H.A.W. hold personal development award National Institute UK. All authors declare conflict interest. REGISTRATION NUMBER CRD42021289098.

Language: Английский

Citations

23
Ovarian function after COVID-19: long-term effects and vaccine safety in ART patients DOI
Yamila Herrero,

Candela Velázquez,

Natalia Pascuali

et al.

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

1
Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples DOI Open Access
Meng Dong, Shanshan Wu, Xue Zhang

et al.

Journal of Assisted Reproduction and Genetics, Journal Year: 2022, Volume and Issue: 39(8), P. 1849 - 1859

Published: June 27, 2022

Language: Английский

Citations

34
Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization DOI Open Access
Weiting Xia, Junzhao Zhao, Yangyang Hu

et al.

Andrologia, Journal Year: 2022, Volume and Issue: 54(6)

Published: May 24, 2022

Since the reproductive toxicity of COVID-19 vaccines have not been assessed in previous clinical trials, and studies shown that SARS-CoV-2 is associated with a decrease sperm parameters. Although it has reported mRNA do adversely affect semen parameters, whether this conclusion applies to inactivated remains unclear. Here, we conducted study among patients who accepted vitro fertilization (IVF) at centre between June August 2021. In enrolled cases, men completed two doses vaccine were included "vaccine group" (N = 105), those vaccinated "control 155). study, compare parameters embryo quality these groups. Our data showed similar terms volume, concentration, count, progressive motility, total motility motile count Similarly, no significant differences observed IVF outcomes. The mean number 2PN, cleavage-stage embryos, blastocysts, good-quality blastocysts was 8.59 ± 4.47, 5.06 3.17 2.08 1.79 group, 7.75 4.14, 4.34 3.06 1.74 1.54 control respectively. high-quality blastocyst rate 41.05% (218 531) group 40.03% (269 672) (p > 0.05). addition, biochemical pregnancy rates summary, our results revealed administration exhibited negative effect on IVF.

Language: Английский

Citations

26
Association Between Time Interval from COVID-19 Vaccination to In Vitro Fertilization and Pregnancy Rate After Fresh Embryo Transfer DOI Creative Commons
Wenhao Shi, Min Wang,

Xia Xue

et al.

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(10), P. e2236609 - e2236609

Published: Oct. 14, 2022

There is a lack of information regarding the need to postpone conception after COVID-19 vaccination.To investigate time interval between first dose inactivated vaccine and in vitro fertilization (IVF) treatment as well rate pregnancy fresh embryo transfer.This cohort study was conducted at single public IVF center China. Female patients aged 20 47 years undergoing were consecutively registered from May 1 December 22, 2021, with follow-up until March 31, 2022. Patients SARS-CoV-2 infection before or during those who underwent 2 more treatments, received noninactivated unknown vaccine, did not have transfer excluded this study.The vaccinated group (subdivided into 4 subgroups vaccination treatment: ≤30 days, 31-60 61-90 ≥91 days) nonvaccinated group.Risk ratios (RRs) for association ongoing (pregnancy continued least 12 weeks).A total 3052 female (mean [SD] age, 31.45 [3.96] years) analyzed study. 667 receiving (35 58 105 469 days treatment), 2385 unvaccinated treatment. The ovarian stimulation laboratory parameters similar among all groups. Ongoing significantly lower 30 less subgroup (34.3% [12 35]; adjusted RR [aRR], 0.61; 95% CI, 0.33-0.91) 31 60 days' (36.2% [21 58]; aRR, 0.63; 0.42-0.85). A slightly but statistically found 61 90 subgroup, no reduced risk 91 observed (56.3% [264 469]; 0.96; 0.88-1.04) compared (60.3% [1439 2385], reference).Findings suggest that receipt associated pregnancy. In transfer, procedure may be delayed vaccination.

Language: Английский

Citations

25
COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome DOI Creative Commons
Soha Albeitawi, Zina M. Al‐Alami, Jehan Hamadneh

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 15, 2022

Abstract To investigate the effect of COVID-19 infection or vaccine on IVF outcome. This is a multicenter retrospective study. Data were collected from all patients treated in ART units between September and November 2021 after vaccination general population began. Medical records who had IVF/intracytoplasmic sperm injection (ICSI) retrospectively reviewed. Patients categorized into four groups: previously infected by COVID-19, vaccinated COVID vaccine, vaccinated, neither nor vaccinated. Total number participants 151 (vaccinated only 66, 18, 34, control 33. Outcomes (ET day trigger, oocytes retrieved, quality oocytes, fertilized embryos, embryos transferred, frozen, implantation rate clinical pregnancy rate) compared these groups. Moreover, we outcome before post infection, as well group patients. No evidence was found to suggest that disease SARS-CoV-2 Vaccine adversely affects Clinical rates (positive fetal heartbeat) (OR 0.9, CI 0.5–1.9, OR 1.8, 0.9–3.6, respectively) following parameters: fertilization rate, positive bHcg) 0.5–1.8, 1.5, 0.7–2.9, respectively). Although limitation our study small comparison groups, wide confidence intervals Odds Ratio estimates.

Language: Английский

Citations

25