Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 28, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
significant
health
burden
in
youths
and
young
adults,
the
trend
toward
younger
onset
of
NAFLD
alarming.
Utilizing
data
from
Global
Burden
Disease
(GBD)
2021
study,
this
study
assessed
trends
adults
aged
15–39
1990
to
extracted
on
incidence,
prevalence,
death,
disability-adjusted
life-years
(DALYs)
rates
NAFLD.
We
evaluated
global
temporal
with
estimated
annual
percentage
change
(EAPC)
age-standardized
rate
(ASR).
The
Bayesian
age-period-cohort
(BAPC)
model
was
used
predict
future
2035.
found
that
has
risen
steadily
2021,
projects
increase
2035,
which
places
enormous
pressure
society.
To
alleviate
burden,
implementing
measures
targeting
risk
factors
such
as
glycemic
control
smoking
cessation
necessary.
Liver International,
Journal Year:
2024,
Volume and Issue:
44(4), P. 1061 - 1070
Published: Feb. 2, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
formerly
known
as
nonalcoholic
fatty
(NAFLD),
is
common
and
closely
associated
with
type
2
diabetes
(T2D).
We
assessed
the
prevalence
of
NAFLD/MASLD
in
general
population
among
patients
T2D
Middle
East
North
Africa
(MENA)
region.
Diabetes Spectrum,
Journal Year:
2024,
Volume and Issue:
37(1), P. 9 - 19
Published: Feb. 1, 2024
The
prevalence
of
nonalcoholic
fatty
liver
disease
(NAFLD)
in
the
United
States
is
38%,
having
increased
by
50%
within
past
3
decades.
estimated
NAFLD
among
people
with
type
2
diabetes
55–70%.
presence
associated
a
higher
likelihood
progression
to
fibrosis
development,
transplant,
and
death.
Cardiovascular
main
cause
mortality
NAFLD,
risk
death
significantly
both
diabetes.
carries
high
patient
economic
burdens
but
low
awareness
general
public
health
care
providers.
This
article
reviews
epidemiology
discusses
need
for
appropriate
stratification,
referral
specialty
care,
management
cardiometabolic
factors,
treatment
disease.
authors
present
call
action
raise
address
its
increasing
burden
systematic
efficient
manner.
The American Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
119(6), P. 1089 - 1101
Published: March 13, 2024
INTRODUCTION:
In
the
United
States,
10.2%
households
(HH)
report
child
food
insecurity.
We
assessed
associations
between
metabolic
dysfunction–associated
fatty
liver
disease
(MASLD)
and
insecurity
among
adolescents
in
States.
METHODS:
This
cross-sectional
study
was
performed
using
data
from
National
Health
Nutrition
Examination
Survey
2017–2018.
Food
by
US
Department
of
Agriculture
Child
Security
Module.
MASLD
defined
transient
elastography.
RESULTS:
Among
771
(aged
12–18
years)
(mean
age
14.7
years;
52.5%
male;
50.9%
White,
12.7%
Black,
24.4%
Hispanic,
12.1%
other),
9.8%
reported
insecurity;
prevalence
10.12%
(95%
confidence
interval
[CI]
7.13%–13.20%)
affecting
4.27
million
adolescents;
nonalcoholic
10.77%
CI
7.76–13.78)
4.52
adolescents.
There
near-perfect
concordance
(Cohen's
κ
coefficient
0.971,
95%
0.946–0.996).
The
greater
food-insecure
vs
food-secure
ones
(17.4%
9.4%)
living
with
a
low
HH
income
those
higher
(15.0%
7.2%)
head
lower
education
level
one
(18.0%
8.2%)
(
P
<
0.05).
fully
adjusted
model
showed
that
compared
income,
had
3-fold
risk
(odds
ratio
[OR]
3.25,
1.31–8.08)
having
MASLD,
while
low-income
no
increased
(OR
1.58,
0.85–2.93,
=
0.139).
odds
elevated
+163%
presence
HTN
2.63,
1.02–6.78),
+241%
being
Hispanic
3.41,
1.36–8.56),
+138%
male
2.38,
1.20–4.75).
addition,
1-unit
increase
BMI
associated
25%
1.25,
1.17–1.33)
DISCUSSION:
is
especially
individuals
obesity
hypertension.
Policies
addressing
inequities
are
needed.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 8, 2024
Background
The
estimated
glucose
disposal
rate
(eGDR),
an
effective
indicator
of
insulin
resistance,
has
been
related
to
acute
coronary
syndrome,
ischemic
stroke
and
heart
failure.
This
study
aims
explore
the
relationship
between
eGDR
arterial
stiffness,
all-cause
mortality
cardiovascular
in
patients
with
non-alcoholic
fatty
liver
disease
(NAFLD).
Methods
Participants
NAFLD
were
chosen
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999
2018.
main
outcomes
are
stiffness
(represented
by
pulse
wave
velocity,
ePWV),
mortality.
Multiple
cox
regression
models,
restricted
cubic
spline,
sensitivity
analysis
subgroup
carried
out
investigate
correlation
resistance
indicators
stiffness.
Furthermore,
receiver
operating
characteristic
curves
used
compare
predictive
value
triglyceride-glucose
(TyG)
index
homeostasis
model
assessment
(HOMA-IR)
for
Results
In
this
study,
a
total
4,861
participants
included
analysis.
After
adjusting
confounding
factors
multivariate
weighted
model,
was
inversely
associated
(Q4
vs.
Q1,
HR
=0.65
(0.48-0.89,
P=0.01)
=0.35
(0.19-0.65,
P<0.001).
Compared
TyG
HOMA-IR,
shows
excellent
(0.588
0.550
0.513,
P
<
0.001)
(0.625
0.553
0.537,
0.001).
addition,
we
found
significant
negative
(β=-0.13(-0.14–0.11,
P<
However,
HOMA-IR
showed
no
Conclusions
Low
(an
resistance)
levels
increased
risk
United
States.
