Factors Associated with Advanced Liver Fibrosis in a Population with Type 2 Diabetes: A Multicentric Study in Mexico City.

Journal of Clinical and Experimental Hepatology, Journal Year: 2025, Volume and Issue: 15(4), P. 102536 - 102536

Published: Feb. 27, 2025

Language: Английский

---

Association between the changes in the estimated glucose disposal rate and new‐onset cardiovascular disease in middle‐aged and elderly individuals: A nationwide prospective cohort study in China

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Previous studies have shown that eGDR and TyG, as indicators of insulin resistance (IR), were key risk factors for cardiovascular disease (CVD). Our study further explored the relationship between change new-onset CVD, compared predictive value change, TyG. A total 2895 participants without CVD at baseline from China Health Retirement Longitudinal Study (CHARLS) included, using K-means clustering cumulative to measure 2012 2015. Cox restricted cubic splines (RCS) regression models assessed CVD. The outcomes was evaluated receiver operating characteristic (ROC) curves, net reclassification improvement (NRI) integrated discrimination (IDI). During a mean follow-up 4.42 years, 581 cases occurred, including 389 heart 249 stroke cases. Participants with consistently low had higher (HR: 2.51, 95%CI: 2.04-3.09). stepwise increase observed increased (p trend <0.001). Further analysis showed correlation linear. Compared exerted greater effect by area under curve, IDI NRI. Sustained related an in middle-aged elderly population. Continuous monitoring significantly enhances accuracy stratification, which may reduce incidence

Language: Английский

---

Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 22, 2025

Insulin resistance (IR) is linked to an increased risk of frailty, yet it remains unclear whether the non-insulin-based IR indicators are associated with frailty trajectories and physical function decline. It aimed examine associations triglyceride-glucose (TyG) index, metabolic score for insulin (METS-IR), estimated glucose disposal rate (eGDR) long-term deficit-accumulation Data from 6722 participants in China Health Retirement Longitudinal Study (CHARLS) were analyzed. Baseline TyG METS-IR, eGDR, along index (FI) over nine years, calculated. FI assessed using group-based trajectory model (GBTM). Logistic regression models used analyze between risk. Restricted cubic splines (RCS) utilized detect potential dose-response associations. Linear mixed-effects was evaluate development speed. Age, gender, educational level, marital status, smoking drinking life satisfaction, social activity sleep duration adjusted. Additionally, a two-sample Mendelian randomization (MR) performed assess causality observed Three including low-stable moderate-increasing accelerated rising identified. Regarding frail risk, each SD increment 16.1% increase (OR = 1.161; 95%CI: 1.092, 1.235). An inverse association eGDR OR (95%CI) being 0.741 (0.696, 0.788). A linear relationship baseline (P nonlinear 0.696), but patterns nonlinearity < 0.010) METS-IR 0.010). Each greater (β 0.005 SD/y; 95%CI 0.002, 0.008 P 0.001). similar pattern highest quartile showed significantly progression, β value 0.013 (95% CI 0.004, 0.022). slower (β=-0.006 SD/y, 95% CI=-0.009, -0.003 Participants presented lower annual change compared 1 group during follow-up (β=-0.013 CI=-0.022, -0.005 trend Similar findings Findings MR analysis causal higher 0.214, 0.079, 0.349; 0.002). The indicators, independently progression Monitoring managing abnormal metabolism should be recommended as part comprehensive strategies prevent or delay frailty.

Language: Английский

---

Association between the cumulative estimated glucose disposal rate and incident cardiovascular disease in individuals over the age of 50 years and without diabetes: data from two large cohorts in China and the United States

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

The estimated glucose disposal rate (eGDR) has been linked to incident cardiovascular disease (CVD) in individuals without diabetes. However, few studies have accounted for long-term cumulative eGDR exposure. aim of this study was explore whether independently associated with CVD over the age 50 years and This used data from China Health Retirement Longitudinal Study (CHARLS) (HRS). calculated as summation average each pair consecutive examinations multiplied by time between these two visits, years. outcome CVD. Cox proportional hazards regression models restricted cubic spline (RCS) were evaluate association A total 2430 participants CHARLS 2008 HRS included analysis. median at baseline 59 [IQR: 55-65 years], 1205 (49.59%) men. 64 57-70 705 (35.11%) RCS model showed a negative linear incidence (CHARLS: P < 0.001, nonlinearity = 0.248; HRS: 0.013, 0.121). After multivariate adjustment, higher levels lower risk (per SD, CHARLS: HR: 0.802, 95% CI: 0.716-0.898, 0.791, 0.665-0.940, pooled analysis: 0.799, 0.726-0.878). level an increased Continuous monitoring exposure time, based on consideration traditional factors, may prove beneficial early identification intervention high In regions limited healthcare resources, among ability access, process, understand health information services, offer improved clinical applicability.

Language: Английский

---

Overweight and obesity in patients with type 1 diabetes: associations with vascular complications and biomarkers of vascular remodeling

Diabetes Mellitus, Journal Year: 2025, Volume and Issue: 27(6), P. 528 - 535

Published: Jan. 18, 2025

BACKGROUND : The prevalence of overweight and obesity in patients with type 1 diabetes (T1D) is increasing, which raises the issue their impact on development complications. AIM to study associations vascular complications, cardiovascular risk factors serum levels remodeling biomarkers T1D. MATERIALS AND METHODS included 547 patients, including 309 body mass index (BMI) <25 kg/m 2 , 155 BMI 25–29.9 83 ≥30 . Insulin sensitivity was assessed by estimated glucose disposal rate. In 130 30 individuals normal weight tolerance, concentrations advanced glycation end products (AGEs), endothelin-1, endothelial NO synthase (NOS3), adrenomedullin (ADM), cell-specific molecule-1 (ESM1), cell adhesion molecules (ICAM-1 VCAM-1), integrin-associated protein-1 (IAP-1), integrin receptor subunit (ITGB1), heme oxygenase-1 (HO-1), GAS6, decorin, transforming growth factor β1 (TGF-β1) were determined ELISA. RESULTS Obesity T1D independently associated coronary artery disease, myocardial infarction, chronic heart failure. Overweight an independent predictor failure only. Patients ≥25 when compared those older, had a reduced insulin increased triglycerides, LDL-cholesterol, uric acid, high-sensitivity C-reactive protein. T1D, as controls, showed significant increase AGEs, ICAM-1, VCAM-1, IAP-1, ESM1, HO-1, TGF-β1. demonstrated higher ITGB1 TGF-β1, while obese IAP-1 HO-1. CONCLUSION are remodeling.

Language: Английский

---

Association between estimated glucose disposal rate and incident cardiovascular disease in a population with Cardiovascular-Kidney-Metabolic syndrome stages 0–3: insights from CHARLS

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 24, 2025

Estimated glucose disposal rate (eGDR) is a reliable marker of insulin resistance (IR), which has been proven to be strongly linked cardiovascular and renal diseases. However, the link between eGDR occurrence disease (CVD) in individuals exhibiting Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0-3 remains ambiguous. The data employed this investigation was procured from China Health Retirement Longitudinal Study (CHARLS). outcome study CVD events, include heart stroke. Cox regression models restricted cubic spline (RCS) were investigate association risk among with CKM 0-3. This encompassed 6,539 subjects, 54.43% female. 1,656 (26.04%) events recorded. After fully adjusting for covariates, each 1-unit increase 9% diminish (HR: 0.91, 95% CI: 0.88, 0.93). In comparison bottom quartile eGDR, adjusted HRs (95% CIs) second fourth quartiles 0.73 0.64, 0.83), 0.65 0.56, 0.76), 0.56 0.47, 0.66), respectively. RCS curves revealed substantial negative nonlinear participants (P-value < 0.001 P = 0.009). population 0-3, significant relationship observed risk, suggesting that might function as useful metric evaluating risk.

Language: Английский

---

Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Magnesium is an essential immune nutrient for the body, and recent studies have found that it plays important role in osteoarthritis (OA). depletion score(MDS) a new method evaluating magnesium status of body. Our objective to explore association between MDS incidence OA, as well relationship mortality patients with OA. Methods Eligible participants were obtained from NHANES 2005 2018. Logistic regression models employed evaluate link Cox among OA patients. In addition, restricted cubic spline was utilized correlation Subgroup analysis adopted order ensure credibility results different subgroups, including age, gender, race, education level, BMI, smoking, diabetes hypertension. Results 19,394 individuals qualified analysis, 3,256 After excluding missing follow-up data, 630 all-cause deaths 172 cardiovascular (CVDs) observed 3,250 The had higher levels MDS. logistic model, positively related (MDS≥3 vs. MDS=0, OR =1.83 (1.46-2.30, P &lt;0.001)). Besides, positive [MDS≥3 HR =2.56 (1.49-4.41, &lt;0.001)] CVDs =3.00 (1.13-7.98, =0.01)] cox models. 1-unit rise significantly linked increased risk mortality. Restricted indicated demonstrated are stable subgroups. Conclusions correlated Optimizing nutritional may bring benefits

Language: Английский

---

Association between estimated glucose disposal rate and prediabetes reversion and progression: a nationwide cohort study of middle-aged and elderly people in China

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Objective Prediabetes is a chronic condition characterized by elevated blood glucose levels that are not yet high enough to be classified as diabetes. It particularly prevalent among middle-aged and elderly populations. This study aims investigate the association between novel marker of insulin resistance-the estimated disposal rate (eGDR)-and reversion prediabetes normoglycaemia or progression diabetes in Chinese population. Methods prospective cohort utilized baseline data from 2011 China Health Retirement Longitudinal Study involving 2,600 prediabetic participants aged 45 years older, along with follow-up 2015. The study’s endpoints were defined according American Diabetes Association criteria, including maintenance state, normoglycaemia, Multivariable Cox regression models restricted cubic spline used assess eGDR populations, followed stratified analyses explore potential population-specific dependencies. Results Over median period 4 years, 1,615 (62.1%) remained 586 (22.5%) reverted 399 (15.3%) progressed In multivariable analyses, our results indicated was positively associated [Hazard Ratio = 1.14, 95% Confidence Interval: 1.05, 1.23], negatively (HR 0.81, CI: 0.70, 0.93). Restricted analysis revealed nonlinear, L-shaped segmented identifying an threshold 6.81 point significant change likelihood reversion. Conclusion populations suggested higher promoted provided protective effect against its

Language: Английский

---

A negative correlation of low estimated glucose disposal rate with significant liver fibrosis in adults with NAFLD and obesity: results from NHANES 2017–2020

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 29, 2025

Abstract Background and aim Nonalcoholic fatty liver disease (NAFLD) with fibrosis is associated liver-related mortality cardiovascular disease. Estimated glucose disposal rate (eGDR), which an insulin resistance–related index, related to the caused by NAFLD. This study aimed investigate predictive value of eGDR for in patients Methods The data from National Health Nutrition Examination Survey 2017–2020.03 were analyzed present study. NAFLD was diagnosed using controlled attenuation parameter (CAP) tests FibroScan ® model 502 V2 Touch. Results 1585 individuals analyzed, including 224 significant 1361 nonsignificant fibrosis. Individuals older had higher CAP values lower eGDRs (both P < 0.01). A negative correlation found between stiffness degrees (odds ratio: 0.643, 95% confidence interval: 0.643–0.726, 0.001); also after adjusting age, sex, ethics ( 0.001). For participants obesity overweight, negatively correlated CAP, body mass index (BMI), waist circumference, C-reactive protein level, white blood cell (WBC) count (all 0.05). multivariate analysis revealed that eGDR, BMI, aspartate aminotransferase (AST), WBC platelet (PLT) counts 0.05) independent risk factors incorporating AST, WBC, PLT AUROC 0.822, superior conventional noninvasive scoring systems, AST-to-PLT ratio fibrosis-4 gamma-glutamyl transpeptidase Conclusion Low obesity, a demonstrated strong evaluation.

Language: Английский

---

Analysis of postprandial time trends and influencing factors of blood glucose and insulin in type 2 diabetes mellitus (T2DM) with metabolic dysfunction-associated steatotic liver disease (MASLD): a retrospective study based on propensity score matching (PSM)

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---