BMC Microbiology,
Journal Year:
2021,
Volume and Issue:
21(1)
Published: April 9, 2021
Abstract
Background
While
aging
is
a
potent
risk
factor
of
dry
eye
disease,
age-related
gut
dysbiosis
associated
with
inflammation
and
chronic
geriatric
diseases.
Emerging
evidence
have
demonstrated
that
contributes
to
the
pathophysiology
or
exacerbation
ocular
diseases
including
disease.
However,
relationship
between
aging-related
changes
in
microbiota
disease
has
not
been
elucidated.
In
this
pilot
study,
we
investigated
association
aging-dependent
microbiome
severity
C57BL/6
male
mice.
Results
Eight-week-old
(8
W,
n
=
15),
one-year-old
(1Y,
10),
two-year-old
(2Y,
8)
mice
were
used.
Dry
was
assessed
by
corneal
staining
scores
tear
secretion.
Bacterial
genomic
16
s
rRNA
from
feces
analyzed.
Main
outcomes
compositional
differences
among
groups
their
correlation
severity.
aged
(1Y
2Y),
increased
secretion
decreased
statistical
significance.
Gut
α-diversity
different
groups.
β-diversity
significantly
univariate
analysis,
phylum
Firmicutes
,
Proteobacteria,
Cyanobacteria
/
Bacteroidetes
ratio,
genus
Alistipes
Bacteroides
Prevotella
Paraprevotella
Helicobacter
related
After
adjustment
age,
multivariate
analysis
revealed
Proteobacteria
Lactobacillus
be
Conclusions
Our
study
suggests
composition
are
signs
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(2), P. 292 - 292
Published: Jan. 20, 2023
The
eye
is
a
metabolically
active
structure,
constantly
exposed
to
solar
radiations
making
its
structure
vulnerable
the
high
burden
of
reactive
oxygen
species
(ROS),
presenting
many
molecular
interactions.
biomolecular
cascade
modification
caused
especially
in
diseases
ocular
surface,
cornea,
conjunctiva,
uvea,
and
lens.
In
fact,
injury
anterior
segment
takes
origin
from
perturbation
pro-oxidant/antioxidant
balance
leads
increased
oxidative
damage,
when
first
line
antioxidant
defence
weakens
with
age.
Furthermore,
stress
related
mitochondrial
dysfunction,
DNA
lipid
peroxidation,
protein
modification,
apoptosis,
inflammation,
which
are
involved
disease
progression
such
as
dry
eye,
keratoconus,
uveitis,
cataract.
different
pathologies
interconnected
through
various
mechanisms
diagnostics
more
relevant
early
stages.
end
point
pathway
release
biomarkers
offering
potential
predictive
pathology.
this
review,
we
have
analysed
inflammatory
processes
front
provide
better
understanding
pathomechanism,
importance
for
diagnosis
diseases,
recent
treatment
diseases.
Clinical Optometry,
Journal Year:
2020,
Volume and Issue:
Volume 12, P. 85 - 94
Published: June 1, 2020
Purpose:
Contact
lens
(CL)
dropout
is
likely
a
major
factor
contributing
to
the
near
stagnant
growth
in
CL
market.
The
purpose
of
this
review
summarize
current
state
knowledge
related
frequency
and
factors
associated
with
it.
Methods:
PubMed.gov
was
searched
on
or
before
March
22,
2020,
terms
"contact
lens"
"dropout"
"cessation"
"disruption"
"discomfort".
Pertinent
articles
were
collected.
references
from
these
likewise
identify
additional
relevant
articles.
Only
manuscripts
written
English
included.
No
study
design
date
exclusions
imposed
review.
Results:
This
literature
found
that
frequent
across
developed
countries,
ranged
between
12.0%
27.4%
(pooled
mean
=
21.7%).
top
cited
reason
for
established
wearers
discomfort,
while
vision
neophyte
wearers.
If
given
chance,
dropouts
are
often
able
successfully
resume
wear
up
74%
time.
While
mixed
regard
promoting
dropout,
meibomian
gland
dysfunction
appears
promote
dropout.
Conclusion:
frequently
encountered
condition
may
be
curtailed
by
early
detection,
patient
education,
alterative
options,
treatment
underlying
ocular
surface
diseases
such
as
dysfunction.
Keywords:
contact
cessation,
dry
eye,
JAMA Ophthalmology,
Journal Year:
2019,
Volume and Issue:
138(1), P. 58 - 58
Published: Nov. 27, 2019
The
incidence
of
dry
eye
disease
has
increased;
the
potential
for
crowdsource
data
to
help
identify
undiagnosed
in
symptomatic
individuals
remains
unknown.To
assess
characteristics
and
risk
factors
associated
with
diagnosed
using
smartphone
app
DryEyeRhythm.A
cross-sectional
study
crowdsourced
was
conducted
including
Japan
who
downloaded
DryEyeRhythm
completed
entire
questionnaire;
duplicate
users
were
excluded.
released
on
November
2,
2016;
from
2016,
January
12,
2018.DryEyeRhythm
collected
demographics,
medical
history,
lifestyle,
subjective
symptoms,
disease-specific
Ocular
Surface
Disease
Index
(100-point
scale;
scores
0-12
indicate
normal,
healthy
eyes;
13-22,
mild
eye;
23-32,
moderate
33-100,
severe
symptoms),
Zung
Self-Rating
Depression
Scale
(total
20
items,
total
score
ranging
20-80,
≥40
highly
suggestive
depression).Multivariate-adjusted
logistic
regression
analysis
used
eye.A
21
394
records
identified
our
database;
4454
users,
included
899
participants
(27.3%)
2395
(72.7%)
eye,
all
questionnaires
their
analyzed.
A
2972
(66.7%)
women;
mean
(SD)
age
27.9
(12.6)
years.
vs
no
younger
(odds
ratio
[OR],
0.99;
95%
CI,
0.987-0.999,
P
=
.02),
female
sex
(OR,
1.99;
1.61-2.46;
<
.001),
pollinosis
(termed
hay
fever
questionnaire)
1.35;
1.18-1.55;
depression
1.78;
1.18-2.69;
.006),
mental
illnesses
other
than
or
schizophrenia
1.87;
1.24-2.82;
.003),
current
contact
lens
use
1.27;
1.09-1.48;
.002),
extended
screen
exposure
1.55;
1.25-1.91;
smoking
1.65;
1.37-1.98;
.001).
0.96;
0.95-0.97;
male
0.55;
0.42-0.72;
as
well
absence
collagen
0.23;
0.09-0.60;
0.50;
0.36-0.69;
ophthalmic
surgery
cataract
laser-assisted
situ
keratomileusis
0.41;
0.27-0.64;
0.64;
0.54-0.77;
.001)
past
0.45;
0.34-0.58;
use.This
study's
findings
suggest
that
research
factors.
These
could
play
a
role
earlier
prevention
more
effective
interventions
disease.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(15), P. 3755 - 3755
Published: Aug. 1, 2019
Dry
eye
disease
(DED)
is
a
multifactorial
syndrome
that
can
be
caused
by
alteration
in
the
quality
or
quantity
of
precorneal
tear
film.
It
considered
one
most
common
ocular
conditions
leading
patients
to
seek
care.
The
current
method
for
diagnostic
evaluations
and
follow-up
examinations
DED
combination
clinical
signs
symptoms
determined
tests
questionnaires,
respectively.
application
powerful
omics
technologies
has
opened
new
avenues
toward
analysis
subjects
health
disease.
Metabolomics
emerging
complementary
research
discipline
all
modern
comprehensive
biological
systems.
identification
distinct
metabolites
integrated
metabolic
profiles
potentially
inform
clinicians
at
an
early
stage
during
monitoring
progression,
enhancing
diagnosis,
prognosis,
choice
therapy.
In
ophthalmology,
metabolomics
gained
considerable
attention
over
past
decade
but
very
limited
such
studies
have
been
reported
on
DED.
This
paper
aims
review
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(2), P. 1313 - 1313
Published: Jan. 11, 2023
Aim:
The
aim
of
the
study
was
to
demonstrate
prevalence
and
risk
factors
dry
eye
symptoms
(DES)
among
university
students
in
Poland.
Material
methods:
A
cross-sectional
survey
conducted
312
Polish
students.
questionnaire
consisted
Ocular
Surface
Disease
Index
(OSDI),
5-Item
Dry
Eye
Questionnaire
(DEQ-5)
questions
regarding
medical
history
factors.
Results:
According
OSDI,
more
than
half
respondents
(57.1%)
have
ocular
surface
disease.
Time
spent
using
electronic
devices
is
correlated
with
scores
gathered
both
OSDI
DEQ-5
(p
<
0.001).
There
a
statistically
significant
dependence
between
psychotropics
=
0.002),
glucocorticosteroids
usage
0.026),
presence
depression
0.001),
diabetes
0.01)
or
allergy
0.008)
proved
questionnaires.
Respondents
refractive
errors
those
living
metropolitan
areas
higher
symptom
intensity(p
0.022).
Stress
felt
by
associated
DES
risk.
No
correlation
smoking
habits
observed.
SARS-CoV-2
infection
severity
0.036).
Conclusion:
Pathogenesis
multifactorial
its
depends
on
several
factors,
genetic
environmental.
Its
young
population
underestimated.
Determining
will
enable
implementation
appropriate
prophylaxis
early
diagnosis.
The Ocular Surface,
Journal Year:
2020,
Volume and Issue:
18(4), P. 583 - 594
Published: July 4, 2020
To
review
the
published
literature
related
to
application
of
intense
pulsed
light
(IPL)
for
treating
meibomian
gland
dysfunction
(MGD).
The
search
included
PubMed
database
and
used
keywords
"Intense
Pulsed
Light
Meibomian
Gland
Dysfunction".
IPL
is
a
new
instrumental
treatment
modality
MGD.
This
was
originally
developed
use
in
dermatology
later
adopted
ophthalmology
therapy
MGD
can
improve
tear
film
stability,
functionality,
as
well
subjective
feeling
ocular
dryness.
However,
reviewed
literature,
there
great
variability
patient
selection,
evaluation
criteria,
protocols
durations.
Numerous
studies
report
that
effective
safe
procedure.
There
potential
further
improvements
procedure,
large
comparative
employing
different
modalities
are
lacking.
Life,
Journal Year:
2023,
Volume and Issue:
13(3), P. 837 - 837
Published: March 20, 2023
Given
the
expanding
elderly
population
in
United
States
and
world,
it
is
important
to
understand
processes
underlying
both
natural
pathological
age-related
changes
eye.
Both
anterior
posterior
segment
of
eye
undergo
biological,
chemical,
physical
properties
driven
by
oxidative
stress.
With
advancing
age,
include
dermatochalasis,
blepharoptosis,
thickening
sclera,
loss
corneal
endothelial
cells,
stiffening
lens.
Changes
lowered
viscoelasticity
vitreous
body,
photoreceptor
cell
loss,
drusen
deposition
at
macula
fovea.
Age-related
ocular
pathologies
including
glaucoma,
cataracts,
macular
degeneration
are
largely
mediated
The
prevalence
these
diseases
expected
increase
coming
years,
highlighting
need
develop
new
therapies
that
address
stress
slow
progression
pathologies.
