Clinical course and management of COVID-19 in the era of widespread population immunity

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(2), P. 75 - 88

Published: Dec. 19, 2023

Language: Английский

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Clinical Practice Recommendations on the Effect of COVID‐19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients

Clinical Transplantation, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

ABSTRACT Introduction Solid organ transplant (SOT) recipients were excluded from clinical trials evaluating the efficacy of COVID‐19 vaccines. There is uncertainty about number doses required to prevent life‐threatening infection, as well in optimal vaccine type and their durability. Our objectives provide recommendations on vaccination doses, vaccine, dose administered, timing SOT recipients. Methods We commissioned a systematic review SOT, focusing patient‐important outcomes. recruited an international, multidisciplinary panel 18 stakeholders, including patient partners summarize our findings using GRADE (grading recommendation, assessment, development, evaluation) framework, rate certainty evidence, develop recommendations. Results recommends routine provision additional after primary series with variant‐appropriate vaccines (strong low evidence). suggest any available WHO‐approved rather than selectively choosing specific receiving single double booster (weak Lastly, we before transplantation when possible Conclusion The evidence used guide these limited by paucity robust randomized strategies outcomes population. higher‐quality overall effects inform practice will require large, trials.

Language: Английский

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Efficacy and safety of COVID-19 vaccination in solid organ transplant recipients: A systematic review and network meta-analysis

American Journal of Transplantation, Journal Year: 2024, Volume and Issue: 24(12), P. 2269 - 2281

Published: Aug. 1, 2024

The impact of COVID-19 vaccination on clinical outcomes in solid organ transplant (SOT) recipients remains unclear. This systematic review and network meta-analysis sought to assess the efficacy safety SOT recipients. We searched 6 databases from inception March 1, 2024 for randomized controlled trials (RCTs) observational studies evaluating different strategies Based patient-important outcomes, we performed frequentist random-effects pairwise meta-analyses meta-analyses, separating RCTs nonrandomized evidence, used Grading Recommendation, Assessment, Development, Evaluation approach our certainty evidence. included (N = 814) 43 125 199). Overall, there is a paucity evidence vaccines including infection, mortality, hospitalization, ICU admission, rejection, demonstrated low very due studies' risk bias. Throughout pandemic, clinicians worked with minimal, low-quality relation this population. In instance future public health emergencies, researchers should collaborate closely patient partners ensure sufficient population outcomes.

Language: Английский

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Executive summary of the consensus statement of the group for the study of infection in transplantation and other immunocompromised host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the treatment of SARS-CoV-2 infection in solid organ transplant recipients

Transplantation Reviews, Journal Year: 2023, Volume and Issue: 37(4), P. 100788 - 100788

Published: Aug. 11, 2023

Language: Английский

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Effectiveness of a Fourth COVID-19 mRNA Vaccine Dose Against the Omicron Variant in Solid Organ Transplant Recipients

Transplantation, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 22, 2023

Background. The effectiveness of booster doses COVID-19 vaccines in solid organ transplant recipients is unclear. We conducted a population-based matched cohort study using linked administrative healthcare databases from Ontario, Canada to estimate the marginal vaccine fourth versus third dose BNT162b2 and mRNA-1273 against clinically important outcomes (ie, hospitalization or death) infection during era Omicron variant. Methods. 3120 with (reference) dose. Recipients were on date (±7 d). used multivariable Cox proportional hazards model occurring between December 21, 2021 April 30, 2022. Results. cumulative incidence COVID-19–related death was 2.8% (95% confidence interval [CI], 2.0–3.7) group compared 1.1% CI, 0.59–1.8) after 84 d follow-up ( P < 0.001). adjusted 70% 47–83) 39% 21–52) SARS-CoV-2 infection. Conclusions. Compared dose, associated improved protection hospitalization, death, era. Results highlight importance recipients.

Language: Английский

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Booster Dose of SARS-CoV-2 mRNA Vaccine in Kidney Transplanted Patients Induces Wuhan-Hu-1 Specific Neutralizing Antibodies and T Cell Activation but Lower Response against Omicron Variant

Viruses, Journal Year: 2023, Volume and Issue: 15(5), P. 1132 - 1132

Published: May 9, 2023

Kidney transplanted recipients (KTR) are at high risk of severe SARS-CoV-2 infection due to immunosuppressive therapy. Although several studies reported antibody production in KTR after vaccination, data related immunity the Omicron (B.1.1.529) variant sparse. Herein, we analyzed anti-SARS-CoV-2 immune response seven and eight healthy controls second third dose mRNA vaccine (BNT162b2). A significant increase neutralizing (nAb) titers were detected against pseudoviruses expressing Wuhan-Hu-1 spike (S) protein both groups, although nAbs lower than controls. S low with no 3rd KTR. Reactivity CD4+ T cells boosting was observed when challenged peptides, while peptides less effective groups. IFN-γ ancestral confirming antigen-specific cell activation. Our study demonstrates that induces KTR, an increment humoral immunity. Instead, cellular immunogenic vaccinated subjects.

Language: Английский

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The Impact of Time between Booster Doses on Humoral Immune Response in Solid Organ Transplant Recipients Vaccinated with BNT162b2 Vaccines

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 860 - 860

Published: May 28, 2024

As solid organ transplant (SOT) recipients remain at risk of severe outcomes after SARS-CoV-2 infections, vaccination continues to be an important preventive measure. In SOT previously vaccinated with least three doses BNT162b2, we investigated humoral responses BNT162b2 booster doses. Anti-SARS-CoV-2 receptor binding domain (RBD) immunoglobulin G (IgG) was measured using in-house ELISA. Linear mixed models were fitted investigate the change in geometric mean concentration (GMC) anti-SARS-CoV-2 RBD IgG participants intervals more or less than six months between last two vaccine. We included 107 a interval vaccine doses, found 1.34-fold GMC per month (95% CI 1.25–1.44), while 1.09-fold 0.89–1.34) resulting rate ratio 0.82 0.66 1.01, p = 0.063). conclusion, administration identical COVID-19 mRNA boosters within may result limited immunogenicity dose.

Language: Английский

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Methodology of comparative studies on the relative effectiveness of COVID-19 vaccines: a systematic review

Osong Public Health and Research Perspectives, Journal Year: 2024, Volume and Issue: 15(5), P. 395 - 408

Published: Oct. 15, 2024

This study aimed to comprehensively outline the methodological approaches used in published research comparing vaccine effectiveness (VE) of coronavirus disease 2019 (COVID-19) vaccines.

Language: Английский

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Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants

Vaccine, Journal Year: 2024, Volume and Issue: 45, P. 126617 - 126617

Published: Dec. 18, 2024

Language: Английский

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SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients

Deleted Journal, Journal Year: 2024, Volume and Issue: 38(4), P. 247 - 256

Published: Dec. 31, 2024

Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 .The adaptive immune responses generated by severe acute respiratory syndrome 2 (SARS-CoV-2) vaccination include humoral and cellular responses.Most studies on the SARS-CoV-2 vaccine have focused primarily immunity, but immunity is vital effectively controlling progression to COVID-19.In SOTRs, vaccine-induced response significantly attenuated compared in healthy individuals.Nevertheless, vaccinated SOTRs exhibit reduced rate severity of infection.This review aims provide concise overview current understanding SOTRs.

Language: Английский

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