AI & Society, Journal Year: 2024, Volume and Issue: unknown
Published: April 3, 2024
Language: Английский
Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(11), P. 1270 - 1276
Published: June 29, 2023
Abstract To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to existence of bidirectional functional loops between brain immune system. This concept suggests constantly monitors changes activity and, turn, can regulate system generate physiologically synchronized response. Therefore, has represent information regarding state system, which occure multiple ways. One such representation is an immunengram, trace partially stored by neurons local tissue. review will discuss our current understanding immunengrams, focusing on their manifestation specific region, insular cortex (IC).
Language: Английский
Citations
24
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 159, P. 105608 - 105608
Published: March 2, 2024
While interoception is of major neuroscientific interest, its precise definition and delineation from exteroception continue to be debated. Here, we propose a functional distinction between based on computational concepts sensor-effector loops. Under this view, the classification sensory inputs as serving or depends loop they feed into, for control either bodily (physiological biochemical) environmental states. We explain utility perspective by examining perception skin temperature, one most challenging cases distinguishing exteroception. Specifically, conceptualising thermoception inference about thermal state body (including skin), which directly coupled thermoregulatory processes. This view emphasises coupling regulation (control) defining property (inference) connects contemporary theories brain-body interactions.
Language: Английский
Citations
12
Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(6), P. 378 - 392
Published: May 10, 2023
Language: Английский
Citations
18
Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 95, P. 103991 - 103991
Published: March 4, 2024
Interoception, the neural sensing of visceral signals, and interoceptive awareness (IA), conscious perception interoception, are crucial for life survival functions mental health. Resilience, capacity to overcome adversity, has been associated with reduced disturbances. Here, we sought evidence our Insula Modular Active Control (IMAC) model that suggest insula, a brain region specialized in processing information, realizes IA contributes resilience health via cortico-subcortical connections.
Language: Английский
Citations
6
eLife, Journal Year: 2024, Volume and Issue: 13
Published: Feb. 8, 2024
Interactions between top-down attention and bottom-up visceral inputs are assumed to produce conscious perceptions of interoceptive states, while each process has been independently associated with aberrant symptomatology in psychiatric disorders, the neural substrates this interface unknown. We conducted a preregistered functional neuroimaging study 46 individuals anxiety, depression, and/or eating disorders (ADE) propensity-matched healthy comparisons (HC), comparing their activity across two tasks differentially recruiting or processing within same scan session. During an task, was voluntarily directed towards cardiorespiratory visual signals. In contrast, during perturbation intravenous infusions isoproterenol (a peripherally-acting beta-adrenergic receptor agonist) were administered double-blinded placebo-controlled fashion drive sensations. Across both tasks, activation converged upon insular cortex, localizing granular ventral dysgranular subregions bilaterally. However, contrasting hemispheric differences emerged, ADE group exhibiting (relative HCs) asymmetric pattern overlap left insula, increased decreased proportions co-activated voxels right respectively. The also showed less agranular anterior insula periods bodily uncertainty (i.e. when anticipating possible isoproterenol-induced changes that never arrived). Finally, post-task connectivity anxiety depression severity. These findings confirm mid-insula as key cortical where prediction meet real-time inputs, especially heightened awareness states. Furthermore, may indeed be ‘locus disruption’ for disorders.
Language: Английский
Citations
4
Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: 44(2), P. 361 - 370
Published: March 12, 2024
Abstract Interoception is one of the pivotal cognitive functions for mechanisms our body awareness, and malfunction interoceptive network thought to be associated with mental illness, including addiction. Within addictive disorders, substance‐based non‐substance‐based addictions are known hold dissociable reward systems. However, little about how awareness between these addiction sub‐types would differ. Subjective was assessed among patients alcohol use disorder ( n = 50) who were subsequently hospitalized or remained out‐patient gambling 41) by Body Awareness component Japanese version Perception Questionnaire (BPQ‐VSFBA‐J) compared them against healthy control 809). Both groups showed significantly lower BPQ than control, no substantial differences inpatients outpatients samples. Notably, scores those group. This evidence may suggest a putative role ability on severity behavioral over
Language: Английский
Citations
4
Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18307 - e18307
Published: July 18, 2023
Interoceptive awareness (IA), the subjective and conscious perception of visceral physiological signals from body, has been associated with functions cortical subcortical neural systems involved in emotion control, mood anxiety disorders. We recently hypothesized that IA its contributions to mental health are realized by a brain interoception network (BIN) linking regions receive ascending interoceptive information brainstem, such as amygdala, insula anterior cingulate cortex (ACC). However, little evidence exists support this hypothesis. In order test hypothesis, we used publicly available dataset contained both anatomical neuroimaging data an objective measure assessed heartbeat detection task. Whole-brain Voxel-Based Morphometry (VBM) was investigate association gray matter volume (GMV) structural covariance (SCN) ACC. The relationship between investigated questionnaires depressive symptoms anxiety. found positive correlation state anxiety, but not symptoms. VBM analysis, only GMV left showed IA. A similar observed parcellated dorsal agranular insula, located SCN right hyper-granular were positively correlated No or observed. These findings revealed previously unknown IA, intra-insula SCNs. results may development non-invasive interventions, e.g., neurofeedback, seeking improve prevent problems,
Language: Английский
Citations
10
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 7, 2025
The relationship between the brain and fatigue is gaining increasing attention, with numerous studies indicating that certain specific regions may be closely linked to fatigue. Our study aimed identify exhibiting significant causal relationships discover potential neurotherapeutic targets associated fatigue, in pursuit of seeking new approaches for treatment. A bidirectional two-sample Mendelian randomization (TSMR) method was employed investigate cortical subcortical gray matter volumes 83 Then, we utilized frontal cortex expression Quantitative Trait Loci data, employing methods Summary-data-based Randomization (SMR) Bayesian colocalization genes exhibit association Finally, transcription levels candidate were assessed a central rat model using RT-qPCR. results TSMR analysis revealed an increased volume right lateral orbitofrontal, left caudal middle frontal, rostral cortices correlated diminished susceptibility SMR identified ECE2, GPX1, METTL21EP, RP11-665J16.1, SNF8 as RT-qPCR confirmed significantly elevated Ece2, Gpx1, Snf8 rats compared controls. findings afford substantial theoretical support connection while also providing novel insights into genetic mechanisms therapeutic particularly
Language: Английский
Citations
0
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 9, 2025
Bipolar disorder (BD) with somatic symptoms is a prevalent and refractory clinical syndrome in young patients. Interoception an important mechanism for coordinating internal physiological mood states to maintain individual homeostasis, its mediating systems brain network dynamics undergo significant development from adolescence adulthood. It remains unclear whether interoception altered how it relates youths BD. This study recruited 71 (aged 14-25) BD during maintenance status 111 age-matched controls. Demographic characteristics, interoceptive sensitivity, symptoms, of depression anxiety were assessed. Mann-Whitney U tests, Kruskal-Wallis H test, partial correlation analysis, multiple linear regression used explore the alteration patients association symptoms. showed lower sensitivity higher than controls (p < 0.001). Those had highest 0.001) but lowest scores not-distracting, not-worrying, self-regulation, trust 0.05). Interoceptive indicators correlated Not-distracting was sole predictor issues, maintaining significance after controlling 0.05), highlighting attentional focus as key factor youths. exhibit deficits issues. The not-distracting aspect significantly correlates BD, providing insights targeted strategies managing psychosomatic this demographic. has several limitations. First, control group's inclusion exclusion criteria lacking validation. Second, assessment relied on screening tools rather validated questionnaires, structured evaluations not conducted. Third, medication effects considered. Fourth, some psychiatric conditions (e.g., borderline personality disorder, obsessive-compulsive etc.) comorbid Finally, causal relationships cannot be inferred, need longitudinal studies.
Language: Английский
Citations
0
Neuroinformatics, Journal Year: 2025, Volume and Issue: 23(2)
Published: April 23, 2025
Language: Английский
Citations
0