Environment International,
Journal Year:
2023,
Volume and Issue:
180, P. 108220 - 108220
Published: Sept. 20, 2023
Microplastics
are
created
for
commercial
use,
shed
from
textiles,
or
result
the
breakdown
of
larger
plastic
items.
Recent
reports
have
shown
that
microplastics
accumulate
in
human
tissues
and
may
adverse
health
consequences.
Currently,
there
no
standardized
environmental
monitoring
systems
to
track
microplastic
accumulation
within
tissues.
Using
Raman
spectroscopy,
we
investigated
temporal
exposures
pollution
Hawai'i
noted
a
significant
increase
discarded
placentas
over
past
15
years,
with
changes
size
chemical
composition
polymers.
These
findings
provide
rare
insight
into
vulnerability
sensitivity
Pacific
Island
residents
illustrate
how
can
be
used
as
an
innovative
system.
Cell stem cell,
Journal Year:
2024,
Volume and Issue:
31(2), P. 181 - 195.e9
Published: Jan. 17, 2024
In
humans,
balanced
invasion
of
trophoblast
cells
into
the
uterine
mucosa,
decidua,
is
critical
for
successful
pregnancy.
Evidence
suggests
that
this
process
regulated
by
natural
killer
(uNK)
cells,
but
how
they
influence
reproductive
outcomes
unclear.
Here,
we
used
our
organoids
and
primary
tissue
samples
to
determine
uNK
affect
placentation.
By
locating
potential
interaction
axes
between
using
single-cell
transcriptomics
in
vitro
modeling
these
interactions
organoids,
identify
a
cell-derived
cytokine
signal
promotes
differentiation
at
late
stage
invasive
pathway.
Moreover,
it
affects
transcriptional
programs
involved
regulating
blood
flow,
nutrients,
inflammatory
adaptive
immune
responses,
as
well
gene
signatures
associated
with
disorders
pregnancy
such
pre-eclampsia.
Our
findings
suggest
mechanisms
on
optimal
immunological
enhance
success.
BJOG An International Journal of Obstetrics & Gynaecology,
Journal Year:
2023,
Volume and Issue:
131(5), P. 538 - 550
Published: Nov. 30, 2023
Epidemiological
data
provide
varying
degrees
of
evidence
for
associations
between
prenatal
exposure
to
ambient
air
pollutants
and
adverse
birth
outcomes
(suboptimal
measures
fetal
growth,
preterm
stillbirth).
To
assess
further
certainty
effects,
this
review
examines
the
experimental
literature
base
identify
mechanisms
by
which
pollution
(particulate
matter,
nitrogen
dioxide
ozone)
could
cause
effects
on
developing
fetus.
It
likely
that
environmental
insult
impacts
multiple
biological
pathways
important
sustaining
a
healthy
pregnancy,
depending
upon
composition
pollutant
mixture
window
owing
changes
in
physiologic
maturity
placenta,
its
circulations
fetus
as
pregnancy
ensues.
The
current
body
indicates
placenta
is
target
tissue,
impacted
variety
critical
processes
including
nitrosative/oxidative
stress,
inflammation,
endocrine
disruption,
epigenetic
changes,
well
vascular
dysregulation
maternal-fetal
unit.
All
above
can
disturb
placental
function
and,
consequence,
contribute
compromised
growth
increasing
risk
stillbirth.
Furthermore,
given
there
often
an
increased
inflammatory
response
associated
with
labour,
inflammation
plausible
mechanism
mediating
premature
delivery.
In
light
urbanisation
ever-changing
climate,
both
increase
negatively
affect
vulnerable
populations
such
pregnant
individuals,
it
hoped
collective
may
decisions
taken
strengthen
quality
policies,
reductions
subsequent
improvements
health
those
not
yet
born.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 383 - 383
Published: Jan. 4, 2025
From
fertilisation
to
delivery,
calcium
must
be
transported
into
and
within
the
foetoplacental
unit
for
intracellular
signalling.
This
requires
very
rapid,
precisely
located
Ca2+
transfers.
In
addition,
from
around
eighth
week
of
gestation,
increasing
amounts
routed
directly
maternal
blood
foetus
bone
mineralisation
through
a
flow-through
system,
which
does
not
impact
concentration.
These
different
processes
are
mediated
by
numerous
membrane-sited
channels,
transporters,
exchangers.
Understanding
mechanisms
is
essential
direct
interventions
optimise
foetal
development
postnatal
health
protect
mother
pre-eclampsia.
Ethical
issues
limit
availability
human
tissue
study.
Our
insight
placental
handling
advancing
rapidly,
enabled
developing
genetic,
analytical,
computer
technology.
Because
their
diverse
sources,
reports
new
findings
scattered.
review
aims
pull
data
together
highlight
areas
uncertainty.
Areas
needing
clarification
include
trafficking,
membrane
expression,
recycling
channels
transporters
in
microvilli;
metabolism
vitamin
D
gestational
diabetes
pre-eclampsia;
vascular
effects
increased
endothelial
Orai
expression
pregnancy-specific
beta-1-glycoproteins
PSG1
PSG9.
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(12)
Published: March 14, 2024
Endogenous
retroviruses
(ERVs)
are
frequently
reactivated
in
mammalian
placenta.
It
has
been
proposed
that
ERVs
contribute
to
shaping
the
gene
regulatory
network
of
trophoblasts,
dominantly
acting
as
species-
and
placental-specific
enhancers.
However,
whether
how
control
human
trophoblast
development
through
alternative
pathways
remains
poorly
understood.
Besides
well-recognized
function
endogenous
retrovirus-H
(HERVH)
maintaining
pluripotency
early
epiblast,
here
we
present
a
unique
role
HERVH
on
lineage
development.
We
found
LTR7C/HERVH
subfamily
exhibits
an
accessible
chromatin
state
lineage.
Particularly,
LTR7C/HERVH-derived
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(6), P. 1774 - 1774
Published: March 20, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
multisystem
disorder
that
presents
with
variety
of
phenotypes
involving
metabolic,
endocrine,
reproductive,
and
psychological
symptoms
signs.
Women
PCOS
are
at
increased
risk
pregnancy
complications
including
implantation
failure,
miscarriage,
gestational
diabetes,
fetal
growth
restriction,
preterm
labor,
pre-eclampsia
(PE).
This
may
be
attributed
to
the
presence
specific
susceptibility
features
associated
before
during
pregnancy,
such
as
chronic
systemic
inflammation,
insulin
resistance
(IR),
hyperandrogenism,
all
which
have
been
an
complications.
Many
reversible
following
lifestyle
interventions
diet
exercise,
pregnant
women
healthy
found
lower
complications,
PE.
narrative
synthesis
summarizes
evidence
investigating
PE
role
nutritional
factors
in
PCOS.
The
findings
suggest
beneficial
aspects
management
PCOS,
recommended
evidence-based
international
guidelines,
extend
improved
outcomes.
Identifying
high-risk
will
allow
targeted
interventions,
early-pregnancy
screening,
surveillance
for
should
included
assessment
algorithms
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7886 - 7886
Published: July 18, 2024
Successful
human
pregnancy
needs
several
highly
controlled
steps
to
guarantee
an
oocyte’s
fertilization,
the
embryo’s
pre-implantation
development,
and
its
subsequent
implantation
into
uterine
wall.
The
placenta
development
ensures
adequate
fetal
nutrition
oxygenation,
with
trophoblast
being
first
cell
lineage
differentiate
during
this
process.
sustains
growth
of
fetus
by
providing
it
oxygen
nutrients
removing
waste
products.
It
is
not
surprising
that
issues
early
can
lead
common
disorders,
such
as
recurrent
miscarriage,
restriction,
pre-eclampsia,
stillbirth.
Understanding
normal
essential
for
recognizing
contextualizing
any
pathological
aberrations
may
occur.
effects
these
become
apparent
until
later
in
pregnancy,
mid
or
advanced
stages.
This
review
discusses
process
embryo
phase,
molecular
mechanisms
involved,
abnormalities
those
are
thought
contribute
pre-eclampsia.
also
covers
histological
hallmarks
pre-eclampsia
found
examination
placental
tissue
from
patients.
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
Biology of Reproduction,
Journal Year:
2024,
Volume and Issue:
110(5), P. 936 - 949
Published: Jan. 25, 2024
The
placenta,
composed
of
chorionic
villi,
changes
dramatically
across
gestation.
Understanding
differences
in
ongoing
pregnancies
are
essential
to
identify
the
role
villi
at
specific
times
gestation
and
develop
biomarkers
prognostic
indicators
maternal-fetal
health.
normative
mRNA
profile
is
established
using
next-generation
sequencing
124
first
trimester
43
third
human
placentas
from
healthy
pregnancies.
Stably
expressed
genes
(SEGs)
not
different
between
trimesters
with
low
variability
identified.
Differential
expression
analysis
versus
adjusted
for
fetal
sex
performed,
followed
by
a
subanalysis
23
matched
control
subject
same
genetic
environmental
background.
Placenta
expresses
14,979
polyadenylated
above
noise
(transcripts
per
million
>
0.66),
10.7%
SEGs
Differentially
(DEGs)
account
86.7%
full
cohort
[false
discovery
rate
(FDR)
<
0.05].
Fold
highly
correlate
(Pearson
=
0.98).
At
stricter
thresholds
(FDR
0.001,
fold
change
1.5),
there
remains
50.1%
DEGs
(3353
upregulated
4155
trimester).
This
largest
atlas
placenta
gestation,
controlling
factors,
demonstrating
substantial
villi.
Specific
may
be
used
understand
throughout
placental
health
that
transpire
which
can
future
development
